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Toksoplazmoz Tanısında Polimeraz Zincir Reaksiyonunun Yeri

Year 2000, Volume: 57 Issue: 3 - Volume: 57 Issue: 3, 195 - 202, 01.12.2000

Abstract

Toxoplasma gondiitüm dünyada insanlarda sık görülen infeksiyon etkenlerinden biridir. İnsantoksoplazmozunun laboratuvar tanısı klasik olarak serolojik testlere dayanmaktadır. Fakat bu testler immünsupresehastalardaki toksoplazma ensefaliti ve pnömonisi ile intrauterin toksoplazma infeksiyonu ve oküler toksoplazmozuntanısında yetersiz kalmaktadır. Polimeraz zincir reaksiyonunun PZR insan örneklerinde kullanılarak T.gondii’yibelirlemedeki yeri birçok çalışma ile araştırılmaktadır. Sonuçlar PZR’nunun intrauterin, oküler, serebral vedissemine toksoplazmozda kullanılabilecek hızlı ve duyarlı bir test olduğunu göstermektedir

References

  • Töre O. Toksoplazmoz. In: Topçu AW, Söyletir G, Doğanay M. (eds) İnfeksiyon Hastalıkları, 1996: 525-532.
  • Ergönül Ö, Tekeli E. Toksoplazmozun tanı ve tedavisine yaklaşım. Türkiye Tıp Dergisi 1995; 2: 185-93.
  • Montoya JG, Remington JS. Toxoplasma gondii. In: Mandell GL, Bennett JE, Dolin R. (eds) Principles and Practice of Infectious Diseases. 5th ed. Pennsylvania Churchill Livingstone, 2000: 2858-89.
  • Remington JS, Mc Leod R. Toxoplasmosis. In: Gorbach SL, Barlett JG, Blacklow NR, eds. Infectious Diseases. 2nd ed. Philadelphia: WB Saunders; 1998: 1620-40.
  • Grover CM, Thulliez P, Remington JS, Boothroyd JC. Rapid prenatal diagnosis of kongenital toxoplasma infection by using polymerase chain reaction and amniotic fluid. J Clin Microbiol 1990; 28: 2297-301.
  • Parmley SF, Goebel FD, Remington JS. Detection of Toxoplasma gondiiin cerebrospinal fluid from AIDS patients by polymerase chain reaction.
  • Grose C, Itani O, Weiner CP. Prenatal diagnosis of fetal infection: advances from amniocentesis to cordocentesis-congen ital toxoplasmosis, rubella, cytomegalovirus, varicella virus, parvovirus and human immunodeficiency virus. Pediatr Infect Dis J 1989; 8: 459-68.
  • Mullis KB, Faloona FA. Specific synthesis of DNA invitro via a polymerase-catalyzed chain reaction. Methods in Enzymology. 1986; 155: 335-350.
  • Montoya JG, Remington JS. Studies on the serodiagnosis of toxoplasmic lymphadenitis. Clin infect Dis 1995; 20: 781-9.
  • Stepick-Biek P, Thulliez P, Araujo FD, Remington JS. IgA antibodies for diagnosis of acute congenital and acquired toxoplasmosis. J Infect Dis 1990; 162: 270-3.
  • Wong SY, Hajdu MP, Ramirez R, et al. The role of specific immunoglobulin E in the diagnosis of acute toxoplasma infection and toxoplasmosis. J Clin Mirobiol 1993; 31: 2952-9.
  • Dannemann BR, Vaughan WC, Thulliez P, Remington JS. Differential agglutination test for diagnosis of recently acquired infection with Toxoplasma gondii. J Clin Microbiol 1990; 28: 1928-33.
  • Ho-Yen DO, Joss AWL, Balfour AH, Smyth ETM, Baird D, Chatterton JMW. Use of the polymerase chain reaction to detect Toxoplasma gondiiin human blood samples. J Clin Pathol 1992; 45: 910-3.
  • Burg JL, Grover CM, Pouletty P, Boothroyd JC. Direct and sensitive detection of a pathogenic protozoan, Toxoplasma gondii, by polymerase chain reaction. J Clin Microbiol 1989; 27: 1787-92.
  • Savva D, Morris JC, Johnson JD, Holliman RE. Polymerase chain reaction for detection of Toxoplasma gondii. J Med Microbiol 1990; 32: 25-31.
  • Joss AWL, Chatterton JMW, Evans R, Ho-Yen DO. Toxoplasma polymerase chain reaction on experimental blood samples. J Med Microbiol 1993; 38: 38-43.
  • Çoşkun HŞ, Samur M, Dinçol D. Non-Hodgkin lenfomalı bir hastada Toxoplasma gondiiinfeksiyonu. Flora 1999; 4: 68-71.
  • Van de Ven E, Galama J, Kraaijeveld C, van Druten J, et al. Value of the polymerase chain reaction for the detection of Toxoplasma gondiiin cerebrospinal fluid from patients with AIDS. Clin Infect Dis 1993; 16: 661-6.
  • Tachikawa N, Goto M, Hoshino Y, et al. Detection of Toxoplasma gondii, Epstein-Barr virus, and JC virus DNAs in the cerebrospinal fluid in acquired immunodeficiency syndrome patients with focal central nervous system complications. Intern Med 1999; 38: 556-62.
  • Derovin F, Sarfati C, Beauvanis B, et al. Prevalence of pulmonary toxoplasmosis in HIV-infected patients. AIDS 1990; 4: 1036.
  • Sing A, Leitritz L, Roggenkamp A, et al. Pulmonary toxoplasmosis in bone marrow transplant recipients: report of two cases and review. Clin Infect Dis 1999; 29: 429-33.
  • Vogel N, Kirisits M, Michael E, et al. Congenital toxoplasmosis transmitted from an immunologically competent mother infected before conception. Clin Infect Dis 1996; 23: 1065-60.
  • Jenum PA, Stray-Pedersen B, Melby KK, et al. Incidence of Toxoplasma gondiiinfection in 35 940 pregnant women in Norway and pregnancy outcome for infected women. J Clin Microbiol 1998; 36: 2900-6.
  • Robert-Gangneux F, Gavinet MF, Ancelle T, et al. Value of prenatal diagnosis and early postnatal diagnosis of congenital toxoplasmosis: retrospective study of 110 cases. J Clin Microbiol 1999; 37: 2893-8.
  • Gratzl R, Hayde M, Kohlhauser C, et al. Follow-up of infants with congenital toxoplasmosis detected by polymerase chain reaction analysis of amniotic fluid. Eur J Clin Mirobiol Infect Dis 1998; 17: 853-8.
  • Foulon W, Pinon JM, Stray-Pederson B, et al. Prenatal diagnosis of congenital toxoplasmosis: a multicenter evaluation of different diagnostic parameters. AM J Obstet Gynecol 1999; 181: 843-7.
  • Jenum PA, Holberg-Petersen M, Melby KK, Stray-Pedersen B. Diagnosis of congenital Toxoplasma gondii infection by polymerase chain reaction (PCR) on amniotic fluid samples. The Norwegian experience. APMIS 1998; 106: 680-6.
  • Joss AWL, Ho-Yen DO. The effects of sample storage on polymerase chain reaction-based detection of Toxoplasma gondii in amniotic fluids. J Med Microbiol 1997; 46: 92-6.
  • Fricker-Hidalgo H, Pelloux H, Racinet C, et al. Detection of Toxoplasma gondiiin 94 placentae from infected women by polymerase chain reaction, in vivo, and in vitro cultures. Placenta 1998; 19: 545-9.
  • Montoya JG, Remington JS. Toxoplasmic chorioretinitis in the setting of acute acquired toxoplasmosis. Clin Infect Dis 1996; 23: 277-82.
  • Montoya JG, Parmley S, Liesenfeld O, Jaffe GJ, Remington JS. Use of the polymerase chain reaction for diagnosis of ocular toxoplasmosis. Ophthalmology 1999; 106: 1554-63.
  • Bou G, Figueroa MS, Marti-Belda P, Navas E, Guerrero A. Value of PCR for detection of Toxoplasma gondiiin aqueous humor and blood samples from immunocompetent patients with ocular toxoplasmosis. J Clin Microbiol 1999; 37: 3465-8.
  • Danise A, Cinque P, Vergani S. Use of polymerase chain reaction assays of aqueous humor in the differential diagnosis of retinitis in patients infected with human immunodeficiency virus.
  • Blanc-Jouvan M, Boibieux A, Fleury J, et al. Chorioretinitis following liver transplantation: detection of Toxoplasma gondiiin aqueous humor. Clin Infect Dis 1996; 22: 184-5.

The Role Of Polymerase Chaın Reaction In The Diagnosis Of Toxoplasmosis

Year 2000, Volume: 57 Issue: 3 - Volume: 57 Issue: 3, 195 - 202, 01.12.2000

Abstract

Toxoplasma gondiiis one of the most common infectious agents among humans throughout the world.Laboratory diagnosis of human toxoplasmosis has relied traditionally on serological tests. But these tests areinadequate in immunocompromised patients toxoplasma encephalitis and pneumonia, intrauterine toxoplasmainfections and ocular toxoplasmosis. Many studies have done to assess the value of detecting T.gondiiin humansamples using polymerase chain reaction PCR . Findings created that PCR could be a rapid and sensitivetechnique for the diagnose of intrauterine, ocular, cerebral and disseminated toxoplasmosis

References

  • Töre O. Toksoplazmoz. In: Topçu AW, Söyletir G, Doğanay M. (eds) İnfeksiyon Hastalıkları, 1996: 525-532.
  • Ergönül Ö, Tekeli E. Toksoplazmozun tanı ve tedavisine yaklaşım. Türkiye Tıp Dergisi 1995; 2: 185-93.
  • Montoya JG, Remington JS. Toxoplasma gondii. In: Mandell GL, Bennett JE, Dolin R. (eds) Principles and Practice of Infectious Diseases. 5th ed. Pennsylvania Churchill Livingstone, 2000: 2858-89.
  • Remington JS, Mc Leod R. Toxoplasmosis. In: Gorbach SL, Barlett JG, Blacklow NR, eds. Infectious Diseases. 2nd ed. Philadelphia: WB Saunders; 1998: 1620-40.
  • Grover CM, Thulliez P, Remington JS, Boothroyd JC. Rapid prenatal diagnosis of kongenital toxoplasma infection by using polymerase chain reaction and amniotic fluid. J Clin Microbiol 1990; 28: 2297-301.
  • Parmley SF, Goebel FD, Remington JS. Detection of Toxoplasma gondiiin cerebrospinal fluid from AIDS patients by polymerase chain reaction.
  • Grose C, Itani O, Weiner CP. Prenatal diagnosis of fetal infection: advances from amniocentesis to cordocentesis-congen ital toxoplasmosis, rubella, cytomegalovirus, varicella virus, parvovirus and human immunodeficiency virus. Pediatr Infect Dis J 1989; 8: 459-68.
  • Mullis KB, Faloona FA. Specific synthesis of DNA invitro via a polymerase-catalyzed chain reaction. Methods in Enzymology. 1986; 155: 335-350.
  • Montoya JG, Remington JS. Studies on the serodiagnosis of toxoplasmic lymphadenitis. Clin infect Dis 1995; 20: 781-9.
  • Stepick-Biek P, Thulliez P, Araujo FD, Remington JS. IgA antibodies for diagnosis of acute congenital and acquired toxoplasmosis. J Infect Dis 1990; 162: 270-3.
  • Wong SY, Hajdu MP, Ramirez R, et al. The role of specific immunoglobulin E in the diagnosis of acute toxoplasma infection and toxoplasmosis. J Clin Mirobiol 1993; 31: 2952-9.
  • Dannemann BR, Vaughan WC, Thulliez P, Remington JS. Differential agglutination test for diagnosis of recently acquired infection with Toxoplasma gondii. J Clin Microbiol 1990; 28: 1928-33.
  • Ho-Yen DO, Joss AWL, Balfour AH, Smyth ETM, Baird D, Chatterton JMW. Use of the polymerase chain reaction to detect Toxoplasma gondiiin human blood samples. J Clin Pathol 1992; 45: 910-3.
  • Burg JL, Grover CM, Pouletty P, Boothroyd JC. Direct and sensitive detection of a pathogenic protozoan, Toxoplasma gondii, by polymerase chain reaction. J Clin Microbiol 1989; 27: 1787-92.
  • Savva D, Morris JC, Johnson JD, Holliman RE. Polymerase chain reaction for detection of Toxoplasma gondii. J Med Microbiol 1990; 32: 25-31.
  • Joss AWL, Chatterton JMW, Evans R, Ho-Yen DO. Toxoplasma polymerase chain reaction on experimental blood samples. J Med Microbiol 1993; 38: 38-43.
  • Çoşkun HŞ, Samur M, Dinçol D. Non-Hodgkin lenfomalı bir hastada Toxoplasma gondiiinfeksiyonu. Flora 1999; 4: 68-71.
  • Van de Ven E, Galama J, Kraaijeveld C, van Druten J, et al. Value of the polymerase chain reaction for the detection of Toxoplasma gondiiin cerebrospinal fluid from patients with AIDS. Clin Infect Dis 1993; 16: 661-6.
  • Tachikawa N, Goto M, Hoshino Y, et al. Detection of Toxoplasma gondii, Epstein-Barr virus, and JC virus DNAs in the cerebrospinal fluid in acquired immunodeficiency syndrome patients with focal central nervous system complications. Intern Med 1999; 38: 556-62.
  • Derovin F, Sarfati C, Beauvanis B, et al. Prevalence of pulmonary toxoplasmosis in HIV-infected patients. AIDS 1990; 4: 1036.
  • Sing A, Leitritz L, Roggenkamp A, et al. Pulmonary toxoplasmosis in bone marrow transplant recipients: report of two cases and review. Clin Infect Dis 1999; 29: 429-33.
  • Vogel N, Kirisits M, Michael E, et al. Congenital toxoplasmosis transmitted from an immunologically competent mother infected before conception. Clin Infect Dis 1996; 23: 1065-60.
  • Jenum PA, Stray-Pedersen B, Melby KK, et al. Incidence of Toxoplasma gondiiinfection in 35 940 pregnant women in Norway and pregnancy outcome for infected women. J Clin Microbiol 1998; 36: 2900-6.
  • Robert-Gangneux F, Gavinet MF, Ancelle T, et al. Value of prenatal diagnosis and early postnatal diagnosis of congenital toxoplasmosis: retrospective study of 110 cases. J Clin Microbiol 1999; 37: 2893-8.
  • Gratzl R, Hayde M, Kohlhauser C, et al. Follow-up of infants with congenital toxoplasmosis detected by polymerase chain reaction analysis of amniotic fluid. Eur J Clin Mirobiol Infect Dis 1998; 17: 853-8.
  • Foulon W, Pinon JM, Stray-Pederson B, et al. Prenatal diagnosis of congenital toxoplasmosis: a multicenter evaluation of different diagnostic parameters. AM J Obstet Gynecol 1999; 181: 843-7.
  • Jenum PA, Holberg-Petersen M, Melby KK, Stray-Pedersen B. Diagnosis of congenital Toxoplasma gondii infection by polymerase chain reaction (PCR) on amniotic fluid samples. The Norwegian experience. APMIS 1998; 106: 680-6.
  • Joss AWL, Ho-Yen DO. The effects of sample storage on polymerase chain reaction-based detection of Toxoplasma gondii in amniotic fluids. J Med Microbiol 1997; 46: 92-6.
  • Fricker-Hidalgo H, Pelloux H, Racinet C, et al. Detection of Toxoplasma gondiiin 94 placentae from infected women by polymerase chain reaction, in vivo, and in vitro cultures. Placenta 1998; 19: 545-9.
  • Montoya JG, Remington JS. Toxoplasmic chorioretinitis in the setting of acute acquired toxoplasmosis. Clin Infect Dis 1996; 23: 277-82.
  • Montoya JG, Parmley S, Liesenfeld O, Jaffe GJ, Remington JS. Use of the polymerase chain reaction for diagnosis of ocular toxoplasmosis. Ophthalmology 1999; 106: 1554-63.
  • Bou G, Figueroa MS, Marti-Belda P, Navas E, Guerrero A. Value of PCR for detection of Toxoplasma gondiiin aqueous humor and blood samples from immunocompetent patients with ocular toxoplasmosis. J Clin Microbiol 1999; 37: 3465-8.
  • Danise A, Cinque P, Vergani S. Use of polymerase chain reaction assays of aqueous humor in the differential diagnosis of retinitis in patients infected with human immunodeficiency virus.
  • Blanc-Jouvan M, Boibieux A, Fleury J, et al. Chorioretinitis following liver transplantation: detection of Toxoplasma gondiiin aqueous humor. Clin Infect Dis 1996; 22: 184-5.
There are 34 citations in total.

Details

Primary Language Turkish
Journal Section Collection
Authors

Semra Tunçbilek This is me

Publication Date December 1, 2000
Published in Issue Year 2000 Volume: 57 Issue: 3 - Volume: 57 Issue: 3

Cite

APA Tunçbilek, S. (2000). Toksoplazmoz Tanısında Polimeraz Zincir Reaksiyonunun Yeri. Türk Hijyen Ve Deneysel Biyoloji Dergisi, 57(3), 195-202.
AMA Tunçbilek S. Toksoplazmoz Tanısında Polimeraz Zincir Reaksiyonunun Yeri. Turk Hij Den Biyol Derg. December 2000;57(3):195-202.
Chicago Tunçbilek, Semra. “Toksoplazmoz Tanısında Polimeraz Zincir Reaksiyonunun Yeri”. Türk Hijyen Ve Deneysel Biyoloji Dergisi 57, no. 3 (December 2000): 195-202.
EndNote Tunçbilek S (December 1, 2000) Toksoplazmoz Tanısında Polimeraz Zincir Reaksiyonunun Yeri. Türk Hijyen ve Deneysel Biyoloji Dergisi 57 3 195–202.
IEEE S. Tunçbilek, “Toksoplazmoz Tanısında Polimeraz Zincir Reaksiyonunun Yeri”, Turk Hij Den Biyol Derg, vol. 57, no. 3, pp. 195–202, 2000.
ISNAD Tunçbilek, Semra. “Toksoplazmoz Tanısında Polimeraz Zincir Reaksiyonunun Yeri”. Türk Hijyen ve Deneysel Biyoloji Dergisi 57/3 (December 2000), 195-202.
JAMA Tunçbilek S. Toksoplazmoz Tanısında Polimeraz Zincir Reaksiyonunun Yeri. Turk Hij Den Biyol Derg. 2000;57:195–202.
MLA Tunçbilek, Semra. “Toksoplazmoz Tanısında Polimeraz Zincir Reaksiyonunun Yeri”. Türk Hijyen Ve Deneysel Biyoloji Dergisi, vol. 57, no. 3, 2000, pp. 195-02.
Vancouver Tunçbilek S. Toksoplazmoz Tanısında Polimeraz Zincir Reaksiyonunun Yeri. Turk Hij Den Biyol Derg. 2000;57(3):195-202.