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Daminozit'in Tavşan Karaciğer Glutatyon-S-Transferaz Aktivitesine Etkisinin Araştırılması

Year 2001, Volume: 58 Issue: 1, 7 - 10, 01.03.2001

İsmihan Göze İzzet Yelkovan Sevtap Bakır Ziynet Çınar

Abstract

Çalışmada tavşan karaciğerinden izole edilen Glutatyon-S-Transferaz'ın etkili bir pestisit olan daminozit ileetkileşimi incelenmiştir. Glutatyon -S-Transferaz enzimi in vitro şartlarda değişik dozlarda daminozit ile muameleedilerek, reaksiyonları gözlenmiştir. Bulgular 1-kloro 2,4 dinitro benzen CDNB substrat olarak kullanıldığında eldeedilen aktivite ile karşılaştırılmıştır. Regresyon ve korelasyon analizi yapılmış ve sonuçlar spesifik aktivite olarakverilmiştir

Keywords

Daminozit Glutatyon -S-transferaz

References

  • Nickell LG. Plant growth regulating Chemicals Vol 2. CRC Pres. Inc Boca Ratr ISBN 08493-5009 (6) Florida USA1983
  • Kvien C.S, De Palma R A, Raczynski A R; Effect of soil and foliar daminozide application on residüe levels in peanut J Agric Food Chem 1989; 37: 200-3
  • Mol HG, Van Dam RC, Vreeken RJ, Steijger OM. Determination of daminozide in apple leaves by liquid chromatography-mass spectrometry. J Chromatogr A 1999; 12: 833(1): 53-60.
  • Mott L. Alar again: science, the media, and the public's right to know. Int J Occup Environ Health 2000; 6 (1): 70.
  • Mott L. Alar the aftermath. Science 1992; 7: 25 (5045) 665.
  • Sagelsdorff P, Lutz W.K, Schlatter; DNA methylation in rat liver by daminozide, 1.1 dimethylhydrazine and dimethylnitrosamine. Fundem Appl Toxic 1988; 11: 723-730
  • Murray KR, Mayes P. A, Granner D. K, Rodwell WV. Harper'ın Biyokimyası I.Böl. 1993; 60: 811-7
  • Zubay G. Biochemistry. 3rd Ed. Addisson Wesley CoUSA 1983; 543.
  • Boyer TD, Vessey D.A, Holcomb C, Soly N; Studies of the relatIonship between the catalitic activitiy and binding of nonsubstrate ligands by GST. Biochem J 1984; 217: 179-85.
  • Habig W, Jacoby W. Methods in Enzymology 1981; 77: 213-31 .
  • Habig W, Pabst M, Jacoby W. GlutatIon-S-transferases. J Biol Chem 1974; 249 (25): 7130-9.
  • Kaleti G, Leder WH. Protein-Lowry handbook of micromethods for the biological sciences. New York,Van Nostrand Reinhold Co. 1974;87-88.
  • Sümbüloğlu K, Sümbüloğlu V. Biyoistatistik. 4. Baskı Özdemir Yayın. Ankara.1993
  • Papdopoulou-Mourkidou E. Postharvest- applied agrochemicals and their residues in fresh fruits and vegetables. J Assoc Anal Chem 1991; 74 (5): 745-6
  • Korkmaz M, Çolak A, Sezgin I. Fare kemik iliği hücrelerinde in vivo olarak mikronukleus testi ile daminozitin etkisinin incelenmesi. Tr J Biology 1994
  • Cabral R, Hakoi K, Hoshiya T, Hasegewa R, Ito N. Lack of carcinogenicity of daminozide, alone or in combination with its contaminant 1,1 dimethylhydrazine,in medium-term bioassay.Terat Carcinog Mutagen 96 ;15 (6): 307-12. Hasegewa R, Cabral R,Hoshiya T, Hakoi K. Carcinogenic potential of some pesticides in a medium- term multi organ bioassay in rats. Int J Cancer. 1993; 28; 54 (3): 489-93
  • Göze İ, Yelkovan I, Çınar Z; Daminozitin civcivlerdeki enzimatik etkileri ve histopatolojisi. Tr J Biology 1995; 19: 22
  • Koshkarian AO, Kocharian ES, Aloian GA, Avakian AKh. Effect of plant growth regulators, hydrazine derivates, on the state of the microzomal systems of the liver. Biull Eksp Biol Med. 1988 ; 106 (7): 40-2.
  • Vessey DA, Boyer TD. Differential activation and inhibition of diferent forms of rat liver GST by the herbicides 4 D and 2-5 D. Toxic Appl Pharm 1984; 73: 492-9 .
  • Cabral R, Hoshiya T, Hakoi K, Hasegawa R,Fukushima S, Ito N. A rapid in vivo bioassay for the carcinogenicity of pesticides. Tumor 1991; 77 (3): 185-8.
  • Siliğ Y, Çelik VK, Atalay A. Daminozit uygulanmasından sonra elde edilen civcivlerde karaciğer sitoplazmik GST ve mikrozomal nitrozo dimetilamin demetilaz aktivitesindeki değişiklikler. Tr J Biology 2000; 24; 119-26.

An Investigation On Effect Of Daminozide To The Glutation-S-Transferase Activity In Rabbit Liver

Year 2001, Volume: 58 Issue: 1, 7 - 10, 01.03.2001

İsmihan Göze İzzet Yelkovan Sevtap Bakır Ziynet Çınar

Abstract

We analyzed the interaction between glutation-S-transferase, which is isolated from the liver of rabbits, anddaminozide which is an effective pesticide. Glutation-S-transferase enzymes were treated with daminozide in vitroconditions at various doses, and the reactions were recorded. The observed activities were compared with theactivity of 1-chloro 2, 4 dinitrobenzen substrate and a regression analaysis was performed to investigate thecorrelation. The result were expressed as spesific activites

Keywords

Daminoside Glutation S-Transferase

References

  • Nickell LG. Plant growth regulating Chemicals Vol 2. CRC Pres. Inc Boca Ratr ISBN 08493-5009 (6) Florida USA1983
  • Kvien C.S, De Palma R A, Raczynski A R; Effect of soil and foliar daminozide application on residüe levels in peanut J Agric Food Chem 1989; 37: 200-3
  • Mol HG, Van Dam RC, Vreeken RJ, Steijger OM. Determination of daminozide in apple leaves by liquid chromatography-mass spectrometry. J Chromatogr A 1999; 12: 833(1): 53-60.
  • Mott L. Alar again: science, the media, and the public's right to know. Int J Occup Environ Health 2000; 6 (1): 70.
  • Mott L. Alar the aftermath. Science 1992; 7: 25 (5045) 665.
  • Sagelsdorff P, Lutz W.K, Schlatter; DNA methylation in rat liver by daminozide, 1.1 dimethylhydrazine and dimethylnitrosamine. Fundem Appl Toxic 1988; 11: 723-730
  • Murray KR, Mayes P. A, Granner D. K, Rodwell WV. Harper'ın Biyokimyası I.Böl. 1993; 60: 811-7
  • Zubay G. Biochemistry. 3rd Ed. Addisson Wesley CoUSA 1983; 543.
  • Boyer TD, Vessey D.A, Holcomb C, Soly N; Studies of the relatIonship between the catalitic activitiy and binding of nonsubstrate ligands by GST. Biochem J 1984; 217: 179-85.
  • Habig W, Jacoby W. Methods in Enzymology 1981; 77: 213-31 .
  • Habig W, Pabst M, Jacoby W. GlutatIon-S-transferases. J Biol Chem 1974; 249 (25): 7130-9.
  • Kaleti G, Leder WH. Protein-Lowry handbook of micromethods for the biological sciences. New York,Van Nostrand Reinhold Co. 1974;87-88.
  • Sümbüloğlu K, Sümbüloğlu V. Biyoistatistik. 4. Baskı Özdemir Yayın. Ankara.1993
  • Papdopoulou-Mourkidou E. Postharvest- applied agrochemicals and their residues in fresh fruits and vegetables. J Assoc Anal Chem 1991; 74 (5): 745-6
  • Korkmaz M, Çolak A, Sezgin I. Fare kemik iliği hücrelerinde in vivo olarak mikronukleus testi ile daminozitin etkisinin incelenmesi. Tr J Biology 1994
  • Cabral R, Hakoi K, Hoshiya T, Hasegewa R, Ito N. Lack of carcinogenicity of daminozide, alone or in combination with its contaminant 1,1 dimethylhydrazine,in medium-term bioassay.Terat Carcinog Mutagen 96 ;15 (6): 307-12. Hasegewa R, Cabral R,Hoshiya T, Hakoi K. Carcinogenic potential of some pesticides in a medium- term multi organ bioassay in rats. Int J Cancer. 1993; 28; 54 (3): 489-93
  • Göze İ, Yelkovan I, Çınar Z; Daminozitin civcivlerdeki enzimatik etkileri ve histopatolojisi. Tr J Biology 1995; 19: 22
  • Koshkarian AO, Kocharian ES, Aloian GA, Avakian AKh. Effect of plant growth regulators, hydrazine derivates, on the state of the microzomal systems of the liver. Biull Eksp Biol Med. 1988 ; 106 (7): 40-2.
  • Vessey DA, Boyer TD. Differential activation and inhibition of diferent forms of rat liver GST by the herbicides 4 D and 2-5 D. Toxic Appl Pharm 1984; 73: 492-9 .
  • Cabral R, Hoshiya T, Hakoi K, Hasegawa R,Fukushima S, Ito N. A rapid in vivo bioassay for the carcinogenicity of pesticides. Tumor 1991; 77 (3): 185-8.
  • Siliğ Y, Çelik VK, Atalay A. Daminozit uygulanmasından sonra elde edilen civcivlerde karaciğer sitoplazmik GST ve mikrozomal nitrozo dimetilamin demetilaz aktivitesindeki değişiklikler. Tr J Biology 2000; 24; 119-26.
There are 21 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

İsmihan Göze This is me

İzzet Yelkovan This is me

Sevtap Bakır This is me

Ziynet Çınar This is me

Publication Date March 1, 2001
Published in Issue Year 2001 Volume: 58 Issue: 1

Cite

APA Göze, İ., Yelkovan, İ., Bakır, S., Çınar, Z. (2001). Daminozit’in Tavşan Karaciğer Glutatyon-S-Transferaz Aktivitesine Etkisinin Araştırılması. Türk Hijyen Ve Deneysel Biyoloji Dergisi, 58(1), 7-10.
AMA Göze İ, Yelkovan İ, Bakır S, Çınar Z. Daminozit’in Tavşan Karaciğer Glutatyon-S-Transferaz Aktivitesine Etkisinin Araştırılması. Turk Hij Den Biyol Derg. March 2001;58(1):7-10.
Chicago Göze, İsmihan, İzzet Yelkovan, Sevtap Bakır, and Ziynet Çınar. “Daminozit’in Tavşan Karaciğer Glutatyon-S-Transferaz Aktivitesine Etkisinin Araştırılması”. Türk Hijyen Ve Deneysel Biyoloji Dergisi 58, no. 1 (March 2001): 7-10.
EndNote Göze İ, Yelkovan İ, Bakır S, Çınar Z (March 1, 2001) Daminozit’in Tavşan Karaciğer Glutatyon-S-Transferaz Aktivitesine Etkisinin Araştırılması. Türk Hijyen ve Deneysel Biyoloji Dergisi 58 1 7–10.
IEEE İ. Göze, İ. Yelkovan, S. Bakır, and Z. Çınar, “Daminozit’in Tavşan Karaciğer Glutatyon-S-Transferaz Aktivitesine Etkisinin Araştırılması”, Turk Hij Den Biyol Derg, vol. 58, no. 1, pp. 7–10, 2001.
ISNAD Göze, İsmihan et al. “Daminozit’in Tavşan Karaciğer Glutatyon-S-Transferaz Aktivitesine Etkisinin Araştırılması”. Türk Hijyen ve Deneysel Biyoloji Dergisi 58/1 (March 2001), 7-10.
JAMA Göze İ, Yelkovan İ, Bakır S, Çınar Z. Daminozit’in Tavşan Karaciğer Glutatyon-S-Transferaz Aktivitesine Etkisinin Araştırılması. Turk Hij Den Biyol Derg. 2001;58:7–10.
MLA Göze, İsmihan et al. “Daminozit’in Tavşan Karaciğer Glutatyon-S-Transferaz Aktivitesine Etkisinin Araştırılması”. Türk Hijyen Ve Deneysel Biyoloji Dergisi, vol. 58, no. 1, 2001, pp. 7-10.
Vancouver Göze İ, Yelkovan İ, Bakır S, Çınar Z. Daminozit’in Tavşan Karaciğer Glutatyon-S-Transferaz Aktivitesine Etkisinin Araştırılması. Turk Hij Den Biyol Derg. 2001;58(1):7-10.