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The Role of Telomeres in Aging and Cancer Relationships

Year 2009, Volume: 66 Issue: 4, 187 - 195, 01.12.2009

Merve Güneri Sümer Aras Demet Cansaran Duman

Abstract

Telomeres have a major role in aging and cancer relationships. In cancer treatment and diagnosis, in addition to the traditional methods, the measurement of telomerase activity would be used as specific markers. The studies conducted on telomerase enzymes showed that they would be used effectively in the treatment of cancer. The role of telomeres in aging has also been the focus of many researches. It has been confirmed that telomere shortening plays universal role in shortening of the life of the human cells. Recent applications in the usage of teleomeres as a retardant in aging and also in cancer treatment are happened to be a promising development in this area.

Keywords

Telomere aging cancer

References

  • Atlı K, Bozcuk AN. Telomerler ve Hücresel Yaşlanma. Geriatri 2002; 5: 111-4.
  • Blasco MA. Telomeres and Human Disease: Aging, Cancer and Beyond. Nature Reviews: Genetics 2005; 6: 611-22.
  • Mc Clintock B. The Stability of Broken Ends of Chromosomes in Zea mays. Genetics 1941; 41: 234-82.
  • Blackburn E. Structure and Function of Telomeres. Nature 1991; 350; 569-72.
  • Smith JS, Johnson FB. Isolation of G-Quadruplex DNA Using NMM-Sepharose Affinity Chromatography. In Baumann P. (eds), G-Quadruplex DNA: Methods and Protocols, Methods in Molecular Biology, vol. 608 DOI 10.1007/978-1-59745-363-9_13, Humana Press; 2010. Murray A. All’s Well That Ends Well. Nature 1990; 797-8.
  • Olovnikov A. Theory of Marginotomy. J. Theor. Biol. 1973; 41:181-90.
  • Morin GB. Telomere Control of Replicative Lifespan. Exp Gerontol 1997; 32: 375-82.
  • Dikmen G, Doğan P. Telomeraz ve Kanser. Türkiye Klinikleri J. Med. Sci. 2003; 23: 334-41.
  • Harley CB, Futcher AB, Greider CW. Telomeres Shorten During Ageing of Human Fibroblasts. Nature 1990; 345: 458-60.
  • Hayflick L, Moorhead PS. The Serial Cultivation of Human Telomerase Activity Diploid Cell Strains. Exp Cell Res 1961; 25: 585-621.
  • Bryan TM, Reddel RR. Telomere Dynamics and Telomerase Activity in In vivo Immortalised Human Cells. Europ J Canc 1997; 33(5): 767-73.
  • Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. Specific Association of Human Telomerase Activity with Immortal Cells and Cancer. Science 1994; 266: 2011-5.
  • Shay JW, Wright WE. Telomerase Activity in Human Cancer. Curr Opin Oncol 1996; 8(1): 66-71.
  • Kim NW. Clinical Implications of Telomerase in Cancer. Europ J Canc 1997; 33(5): 781-6.
  • Nakatani K, Yoshimi N, Mori H, Yoshimura S, Sakai H, Shinoda J, Sakai N. The significant role of Telomerase Activity in Human Brain Tumors. Cancer 1997; 80(3): 471-6.
  • Bednarek AK, Sahin A, Brenner AJ, Johnston DA, Aldaz CM. Analysis of Telomerase activity levels in Breat Cancer. Clin Canc Resear 1997; 3(1): 11-6.
  • Yoshida K, Sugino T, Tahara H, Woodman A, Bolodeoku J, Nargund V. Telomerase activity in Bladder Carcinoma and its implication for noninvasive diagnosis by detection of exfoliated cancer cells in urine. Cancer 1997; 79: 362-9.
  • Ito H, Kyo S, Kanaya T, Takakura M, Koshida K, Namiki M, Inoue M. Cancer Research Detection of Human Telomerase Reverse Transcriptase Messenger RNA in Voided Urine Samples as A Useful Diagnostic Tool for Bladder Cancer. Clin Canc Resear 1998; 4(11): 2807-10.
  • Kyo S, Takakura M, Kohama T, Inoure M. Telemerase Activity in Human Endometrium. Canc Resear 1997; 57: 610-4.
  • Akbay, E.,Contreras, C.M, Perera, S.A., Sullivan, J.P, Broaddus, R.R., Schorge, J.O., Raheela A., Saboorian, H., Wong, K.K, Castrillon, H.D. Differential Roles of Telomere Attrition in Type I and II Endometrial Carcinogenesis. Am J Pathol 2008;173: 536-44.

TELOMERLERİN YAŞLANMA VE KANSER İLİŞKİSİNDEKİ ROLÜ

Year 2009, Volume: 66 Issue: 4, 187 - 195, 01.12.2009

Merve Güneri Sümer Aras Demet Cansaran Duman

Abstract

Telomerlerin yaşlanma ve kanser ilişkisindeki rolü oldukça önemlidir. Kanser tedavisinde ve teşhisinde geleneksel yöntemlerin yanı sıra telomeraz aktivitesinin ölçümü özgün bir belirteç olarak kullanılabilir. Telomeraz enzimleri ile ilgili yapılmış olan çalışmalar kanser tedavisinde etkili bir şekilde kullanılabileceklerini göstermektedir. Ayrıca telomerlerin yaşlanma üzerindeki rolleri de birçok araştırmanın odak noktası olmuştur. Telomer kısalmasının insan hücresinin ömür uzunluğunun kısalmasında evrensel bir rol oynadığı yapılan çalışmalarla doğrulanmıştır. Telomerlerin, kanser tedavisinde ve yaşlanmayı geciktirici olarak kullanıma geçmiş olması umut verici bir gelişme olmuştur.

Keywords

Telomer yaşlanma kanser

References

  • Atlı K, Bozcuk AN. Telomerler ve Hücresel Yaşlanma. Geriatri 2002; 5: 111-4.
  • Blasco MA. Telomeres and Human Disease: Aging, Cancer and Beyond. Nature Reviews: Genetics 2005; 6: 611-22.
  • Mc Clintock B. The Stability of Broken Ends of Chromosomes in Zea mays. Genetics 1941; 41: 234-82.
  • Blackburn E. Structure and Function of Telomeres. Nature 1991; 350; 569-72.
  • Smith JS, Johnson FB. Isolation of G-Quadruplex DNA Using NMM-Sepharose Affinity Chromatography. In Baumann P. (eds), G-Quadruplex DNA: Methods and Protocols, Methods in Molecular Biology, vol. 608 DOI 10.1007/978-1-59745-363-9_13, Humana Press; 2010. Murray A. All’s Well That Ends Well. Nature 1990; 797-8.
  • Olovnikov A. Theory of Marginotomy. J. Theor. Biol. 1973; 41:181-90.
  • Morin GB. Telomere Control of Replicative Lifespan. Exp Gerontol 1997; 32: 375-82.
  • Dikmen G, Doğan P. Telomeraz ve Kanser. Türkiye Klinikleri J. Med. Sci. 2003; 23: 334-41.
  • Harley CB, Futcher AB, Greider CW. Telomeres Shorten During Ageing of Human Fibroblasts. Nature 1990; 345: 458-60.
  • Hayflick L, Moorhead PS. The Serial Cultivation of Human Telomerase Activity Diploid Cell Strains. Exp Cell Res 1961; 25: 585-621.
  • Bryan TM, Reddel RR. Telomere Dynamics and Telomerase Activity in In vivo Immortalised Human Cells. Europ J Canc 1997; 33(5): 767-73.
  • Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. Specific Association of Human Telomerase Activity with Immortal Cells and Cancer. Science 1994; 266: 2011-5.
  • Shay JW, Wright WE. Telomerase Activity in Human Cancer. Curr Opin Oncol 1996; 8(1): 66-71.
  • Kim NW. Clinical Implications of Telomerase in Cancer. Europ J Canc 1997; 33(5): 781-6.
  • Nakatani K, Yoshimi N, Mori H, Yoshimura S, Sakai H, Shinoda J, Sakai N. The significant role of Telomerase Activity in Human Brain Tumors. Cancer 1997; 80(3): 471-6.
  • Bednarek AK, Sahin A, Brenner AJ, Johnston DA, Aldaz CM. Analysis of Telomerase activity levels in Breat Cancer. Clin Canc Resear 1997; 3(1): 11-6.
  • Yoshida K, Sugino T, Tahara H, Woodman A, Bolodeoku J, Nargund V. Telomerase activity in Bladder Carcinoma and its implication for noninvasive diagnosis by detection of exfoliated cancer cells in urine. Cancer 1997; 79: 362-9.
  • Ito H, Kyo S, Kanaya T, Takakura M, Koshida K, Namiki M, Inoue M. Cancer Research Detection of Human Telomerase Reverse Transcriptase Messenger RNA in Voided Urine Samples as A Useful Diagnostic Tool for Bladder Cancer. Clin Canc Resear 1998; 4(11): 2807-10.
  • Kyo S, Takakura M, Kohama T, Inoure M. Telemerase Activity in Human Endometrium. Canc Resear 1997; 57: 610-4.
  • Akbay, E.,Contreras, C.M, Perera, S.A., Sullivan, J.P, Broaddus, R.R., Schorge, J.O., Raheela A., Saboorian, H., Wong, K.K, Castrillon, H.D. Differential Roles of Telomere Attrition in Type I and II Endometrial Carcinogenesis. Am J Pathol 2008;173: 536-44.
There are 20 citations in total.

Details

Primary Language Turkish
Journal Section Collection
Authors

Merve Güneri This is me

Sümer Aras This is me

Demet Cansaran Duman This is me

Publication Date December 1, 2009
Published in Issue Year 2009 Volume: 66 Issue: 4

Cite

APA Güneri, M., Aras, S., & Cansaran Duman, D. (2009). TELOMERLERİN YAŞLANMA VE KANSER İLİŞKİSİNDEKİ ROLÜ. Türk Hijyen Ve Deneysel Biyoloji Dergisi, 66(4), 187-195.
AMA Güneri M, Aras S, Cansaran Duman D. TELOMERLERİN YAŞLANMA VE KANSER İLİŞKİSİNDEKİ ROLÜ. Turk Hij Den Biyol Derg. December 2009;66(4):187-195.
Chicago Güneri, Merve, Sümer Aras, and Demet Cansaran Duman. “TELOMERLERİN YAŞLANMA VE KANSER İLİŞKİSİNDEKİ ROLÜ”. Türk Hijyen Ve Deneysel Biyoloji Dergisi 66, no. 4 (December 2009): 187-95.
EndNote Güneri M, Aras S, Cansaran Duman D (December 1, 2009) TELOMERLERİN YAŞLANMA VE KANSER İLİŞKİSİNDEKİ ROLÜ. Türk Hijyen ve Deneysel Biyoloji Dergisi 66 4 187–195.
IEEE M. Güneri, S. Aras, and D. Cansaran Duman, “TELOMERLERİN YAŞLANMA VE KANSER İLİŞKİSİNDEKİ ROLÜ”, Turk Hij Den Biyol Derg, vol. 66, no. 4, pp. 187–195, 2009.
ISNAD Güneri, Merve et al. “TELOMERLERİN YAŞLANMA VE KANSER İLİŞKİSİNDEKİ ROLÜ”. Türk Hijyen ve Deneysel Biyoloji Dergisi 66/4 (December 2009), 187-195.
JAMA Güneri M, Aras S, Cansaran Duman D. TELOMERLERİN YAŞLANMA VE KANSER İLİŞKİSİNDEKİ ROLÜ. Turk Hij Den Biyol Derg. 2009;66:187–195.
MLA Güneri, Merve et al. “TELOMERLERİN YAŞLANMA VE KANSER İLİŞKİSİNDEKİ ROLÜ”. Türk Hijyen Ve Deneysel Biyoloji Dergisi, vol. 66, no. 4, 2009, pp. 187-95.
Vancouver Güneri M, Aras S, Cansaran Duman D. TELOMERLERİN YAŞLANMA VE KANSER İLİŞKİSİNDEKİ ROLÜ. Turk Hij Den Biyol Derg. 2009;66(4):187-95.