Epitelyal Olmayan Over Kanserlerinde Pcna Ekspresyonu Ve Prognoza Etkileri

Year 2010, Volume: 67 Issue: 1, 13 - 19, 01.03.2010

Faruk Abike Sema Zengeroglu İlkkan Dünder

Abstract

Amaç: PCNA kolorektal ve mesane karsinomlarında proliferasyon belirteci olarak kullanılmaktadır. Bu çalışmada, PCNA’nın non-epitelyal over tümörlerinde proliferasyon indeksi olarak kullanılabilirliği araştırılmıştır. Yöntem: Patolojik olarak non-epitelyal over kanseri tanısı alan 30 olgunun PCNA immünreaktivitesi, streptoavidin-biotin antikor kompleksi kullanılarak değerlendirilmiştir. PCNA immünreaktivitesi ve Lİ indeksi ile non-epitelyal tümörlerdeki stage, grade ve lenf nodu tutulumu arasındaki olası ilişki araştırılmıştır. Bulgular: Çalışmamıza alınan hastaların yaş ortalaması 52.6 ± 6.7, ortalama doğum sayısı 3.1±1.5 ve ortalama vücut kitle indeksleri 26.7 ± 4.2 kg/m2 olarak belirlenmiştir. Olguların % 83’ü postmenopozal, % 17’si premenopozal dönemde olduğu, % 47’sinin 5 yıldan uzun süreli sigara kullanımı öyküsü bulunduğu saptanmıştır. En sık rastlanan histolojik tipin disgerminom % 27 olduğu, klinik evrelerine göre dağılımlarının ise; stage 1, 2, 3 ve 4 için sırasıyla % 33, % 13, % 47, % 7 olduğu gözlenmiştir. Histolojik olarak % 47’si grade 3, % 33’ü grade 2 ve % 20’si grade 1 olarak belirlenmiştir. Nonepitelial over tümörlerinde klinik stage ve grade arttıkça PCNA immunureaktivitesi ve Li indeksi de parelel olarak anlamlı artış göstermiştir p0.05 . Sonuç: Non epitelial over tümörlerde klinik ve histolojik evre ile PCNA ekspresyonu arasında bir korelasyon bulunmakla beraber, tümör proliferasyonu indeksi olarak PCNA kullanımı için daha ileri çalışmalar yapılması gerekmektedir.

Keywords

Non epitelyal over tümörleri, PCNA, prognoz

Pcna Expression in Non-Epithelial Ovarian Tumors and Correlation of Prognosis

Abstract

Objective: In colorectal and bladder carcinoma PCNA is used as a proliferation marker. In this study the utility of PCNA as a proliferation index in non-epithelial ovarian tumors was examined.Method: In 30 cases diagnosed by routine pathological procedures as non-epithelial ovarian cancer, the PCNA immunoreactivity was evaluated by a streptoavidin-biotin antibody complex. The possible correlations between PCNA immunoreactivity and LI index with stage, grade and lymph node involvement in non epithelial ovarian tumors were investigated. Results: In our study, average patient age 52.6 ± 6.7 years old, average parity 3.1±1.5 and average BMI 26.7 ± 4.2 kg/m2 were determined. It was found that 83 % of the patients were at postmenopausal period and 17 % premenopausal; 47 % of patients were smoking over the five years. Most common hystological type was found as dysgerminoma 27% and clinical stage distributions were determined as stage 1 33% , stage 2 13% , stage 3 47% , stage 4 7% in all patients. Grade 1 20% , grade 2 33% and grade 3 47% were found according to histological classification.In our study, it was determined in non-epithelial ovarian tumors that as stage and grade of tumor increased, PCNA immunoreactivity and LI index were also elevated statistically p

Keywords

Non epithelial ovarian tumors, PCNA, Prognosis

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