HIV ile enfekte olan obez bireylerde Sistatin- C

Year 2019, Volume: 76 Issue: 4, 461 - 468, 01.12.2019

Dilek Yağcı Çağlayık Hakkı Arıkan Serpil Çeçen

Abstract

Amaç: Sistatin-C böbrek fonksiyonlarını gösteren glomerüler filtrasyon hızını GFR belirlemede kullanılan bir parametre olup obezitede arttığı bilinmektedir. Bu çalışmada amacımız HIV ile enfekte olan obez bireylerde GFR hesaplamasında Sistatin-C’nin etkisini araştırmaktır.Yöntem: Enfeksiyon Hastalıkları HIV polikliniğine başvuran HIV ile enfekte hastalardan obez olanlar çalışmaya dahil edildi. Bireylerin düz bir zeminde çıplak ayakla ve sırtları duvara gelecek şekilde dururken boy uzunlukları ölçüldükten sonra bioimpedans cihazında Tip-BC-418-MAIII, Tanita Body Composition Analyzer; Tanita, Tokyo, Japan tüm vücut analizi yapılarak kilo, beden kütle indeksi BMI , yağ yüzdesi, yağ ağırlığı ve yağsız ağırlıkları tespit edildi. Biyokimyasal verilerine retrospektif olarak ulaşılarak değerlendirme yapıldı. Sistatin-C, kreatinin değerleri ölçülmüş olan hastaların CKD- EPİ GFR Chronic Kidney Disease Epidemiology Collaboration equation glomerular filtration rate , GFRcr kreatinin-GFR , GFRcys sistatin-GFR ve GFRcrcys kombine-GFR değerleri hesaplandı.Bulgular: Yağ yüzdesi fazlalığı %9.21’in üstünde olan HIV ile enfekte bireylerde n=5 , sistatin-C’nin; vücut ağırlığı ve total kolesterol ile orantılı olarak yüksek bir group of HIV infected and excess fat percentage over 9.21%. Cystatin-C decreased with GFRcys in the group of HIV infected and excess fat percentage under 9.21%.Conclusion: Higher correlation with cystatin-C and high body weight in HIV infected with excess fat percentage obese individuals suggests that inflammation due to HIV infection and excess fat mass together contribute to cystatin-C increasing levels. More studies are needed in large number of groups

Keywords

HIV enfeksiyonu, GFR, obezite, yağ dokusu

Cystatin-C in HIV-infected obese individuals

Abstract

Objective: Cystatin-C is a parameter used to determine the glomerular filtration rate GFR which indicates renal function. It is also known that cystatin-C increases in obesity. The aim of this study was to investigate the effect of cystatin-C on GFR calculation in HIV-infected obese individuals.Methods: Female and male HIV-infected obese patients who applied to the Infectious Diseases outpatient clinic were included in the study. Their heights were measured while they were barefooted and back touching a wall. The weight, body mass index BMI , fat percentage, fat mass and fat free mass, were determined using Bio-impedance analyzer device Tip-BC-418-MAIII, Tanita Body Composition Analyzer; Tanita, Tokyo, Japan . Biochemical data of patients were evaluated retrospectively. CKD- EPI GFR Chronic Kidney Disease Epidemiology Collaboration equation glomerular filtration rate , GFRcr creatinin-GFR , GFRcys cystatin-GFR ve GFRcr-cys combined-GFR were calculated using creatinin and cystatin-C values.Results: Cystatin-C proportionally increased with a high correlation with body weight and total cholesterol, and decreased with GFRcr, GFRcys, GFRcr-cys in the en önemli sağlık sorunlarından biri haline gelmiş Dünyada olduğu gibi ülkemizde de obezite group of HIV infected and excess fat percentage over 9.21%. Cystatin-C decreased with GFRcys in the group of HIV infected and excess fat percentage under 9.21%.Conclusion: Higher correlation with cystatin-C and high body weight in HIV infected with excess fat percentage obese individuals suggests that inflammation due to HIV infection and excess fat mass together contribute to cystatin-C increasing levels. More studies are needed in large number of groups

Keywords

HIV infection, GFR, obesity, fat mass

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