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Nano-ilaç taşıma sistemleri ve toksikolojik değerlendirmeleri

Year 2020, Volume: 77 Issue: 4, 509 - 526, 01.12.2020

Abstract

Bilim ve teknoloji dünyasına 1960’lı yılların başından itibaren giren nanoteknoloji, nanometre boyutundaki parçacıkların Nanoteknoloji günümüzde organik kimya, moleküler biyoloji, endüstri, elektronik ve sağlık gibi birçok alanda kullanılmaktadır. Nanoteknolojinin özellikle sağlık alanında kullanılması ile hastalıkların erken teşhisi, önlenmesi ve daha iyi takibi mümkün olabilmektedir. Beşeri ve veteriner hekimlikte ilaç etkin maddelerinin çeşitli nedenlerle etki yerinde istenen yoğunluğa ulaşamaması veya toksik düzeyin üstüne çıkması sıklıkla karşılaşılan istenmeyen durumlardır. Bu nedenle bütün dünyada etkin maddeyi hedef bölgeye yüksek yoğunluklarda ulaştıran ve istenmeyen etkileri mümkün olduğunca azaltan ilaç taşıma sistemleri elde edilmesi için çalışmalar yürütülmektedir. Bu amaçla son yıllarda nanoteknoloji yardımıyla geliştirilen nano-ilaç salınım sistemleri ile birlikte ilaç aktif maddeleri etki yerinde yeterli yoğunluğa ulaştırılabilmekte, sadece hedeflenen organ, doku ve hücrelerde etkin olabilmekte ve kullanılan doz ve doz aralığı azaltılarak istenmeyen etkilerin önüne geçilebilmektedir. Bunun gibi birçok avantaja sahip olmasına rağmen nano-ilaç komplekslerinin boyutları ve bileşenlerinin çok küçük olması nedeniyle, insan ve evcil hayvanların bu yapılara maruziyet riski oldukça artmıştır ve toksik etkilerinin olup olmadığı tartışmalı hale gelmiştir. Bu nedenle nano-ilaç salınım sistemlerinin güvenliklerinin çalışmalar önem kazanmıştır. Yapılan araştırmalarda nanomateryallerin hücrelerde apoptoz, nekroz, otofaji, mitotik yıkımlanma gibi istenmeyen etkilere yol açtıkları rapor edilmiştir. Ancak bu tür sonuçların elde edildiği toksikolojik araştırmalar daha çok in vitro denemelerdir ve in vivo çalışmaların yetersizliğinden dolayı nanoilaç ve nano-ilaç taşıma sistemlerinin canlı vücudu üzerindeki etkileri tam olarak ortaya konamamıştır. Bu nedenle nano-ilaçların toksisitesi konusunda ayrıntılı, sistematik ve uzun soluklu in vivo çalışmalara ihtiyaç duyulmaktadır. Bu derlemede, önemli nano-ilaç ve nano-ilaç taşıma sistemleri ile ilaç taşıma sistemlerinde kullanılan nanomateryallerin toksisitesi ve güvenli kullanımları değerlendirilmiştir.tespitine yönelik toksikolojik

References

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Nano-drug delivery systems and their toxicological assessment

Year 2020, Volume: 77 Issue: 4, 509 - 526, 01.12.2020

Abstract

Nanotechnology, which involved in the science and technology from beginning of 1960s, defined as science of nano-sized particles. Nanotechnology is used in many fields, such as organic chemistry, molecular biology, industry, electronic and medicine. Thanks to usage of nanotechnology in the health sector, early diagnosis, prevention and better monitoring of diseases can be possible. Lower access of drug active ingredients than desired concentrations and their higher accumulations than the toxic levels in the action point are usual adverse effects in human and veterinary medicine. Therefore, studies are performed worldwide on drug delivery systems for transferring active ingredients in high concentrations to the target place and for reducing adverse effects as much as possible. Owing to nano-drug delivery systems, active ingredients can be transported to the effect point; they can be effective only in the target organ, tissue and cells; dose and dose intervals can be reduced and adverse effects can be decreased. But, because of small sizes of nano-drug complexes, exposure risk of humans and domestic animals to these materials increased and their toxic effects became conflictive. Thus, toxicity evcil hayvanların bu yapılara maruziyet riski oldukça artmıştır ve toksik etkilerinin olup olmadığı tartışmalı hale gelmiştir. Bu nedenle nano-ilaç salınım sistemlerinin güvenliklerinin çalışmalar önem kazanmıştır. Yapılan araştırmalarda nanomateryallerin hücrelerde apoptoz, nekroz, otofaji, mitotik yıkımlanma gibi istenmeyen etkilere yol açtıkları rapor edilmiştir. Ancak bu tür sonuçların elde edildiği toksikolojik araştırmalar daha çok in vitro denemelerdir ve in vivo çalışmaların yetersizliğinden dolayı nanoilaç ve nano-ilaç taşıma sistemlerinin canlı vücudu üzerindeki etkileri tam olarak ortaya konamamıştır. Bu nedenle nano-ilaçların toksisitesi konusunda ayrıntılı, sistematik ve uzun soluklu in vivo çalışmalara ihtiyaç duyulmaktadır. Bu derlemede, önemli nano-ilaç ve nano-ilaç taşıma sistemleri ile ilaç taşıma sistemlerinde kullanılan nanomateryallerin toksisitesi ve güvenli kullanımları değerlendirilmiştir.tespitine yönelik toksikolojik

References

  • Tüylek Z. İlaç taşıyıcı sistemler ve nanoteknolojik etkileşim. Bozok Tıp Derg, 2017; 7(3): 89-98.
  • Lamprecht A. Nanotherapeutics: Drug Delivery Concepts in Nanoscience. Singapore: Pan Stanford, 2016.
  • Yavuz O, Marangoz Ö. Farmakoloji ve toksikolojide in siliko yöntemlerin kullanımı. In: Güvenç D, ed. İlaç Araştırma, Geliştirme ve Toksikolojik Çalışmalarda Kullanılan Alternatif Yöntemler, 1. Baskı. Ankara. Türkiye Klinikleri, : 35-42.
  • Marangoz Ö. Nano ilaç ve nano ilaç taşıma sistemleri. Doktora Semineri, Ondokuz Mayıs Üniversitesi Sağlık Bilimleri Enstitüsü, 2018.
  • Vural GU, Özer AY. Nükleer tıpta ilaç taşıyıcı sistemler ve teranostik Kullanımları. Nükleer Tıp Seminerleri, 2015; (2): 109-19.
  • Sayıner Ö, Çomoğlu T. Nanotaşıyıcı sistemlerde hedeflendirme. Ankara Ecz Fak Derg, 2016;
  • Bhargav E, Madhuri N, Ramesh K, Anand M, Ravi V. Targeted drug delivery-A review. World J Pharm Pharm Sci, 2013; 3(1): 150-9.
  • Roursgaard M, Knudsen KB, Northeved H, Persson M, Christensen T, Kumar PE et.al. In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines. Toxicology in Vitro, ; 36: 164-71.
  • Yin X, Luo L, Li W, Yang J, Zhu C, Jiang M et.al. A cabazitaxel liposome for increased solubility, enhanced antitumor effect and reduced systemic toxicity. Asian J Pharm Sci, 2019; 14(6): 658-67.
  • Pippa N, Stangel C, Kastanas I, Triantafyllopoulou E, Naziris N, Stellas D et.al. Carbon nanohorn/ liposome systems: Preformulation, design and in vitro toxicity studies. Materials Sci Engin C, ; 105: 110114.
  • Abud MB, Louzada RN, Isaac DLC, Souza LG, Dos Reis RG, Lima EM et.al. In vivo and in vitro toxicity evaluation of liposome-encapsulated sirolimus. Intern J Retina Vitreous, 2019; 5(1):
  • Zhang Y, Li N, Suh H, Irvine DJ. Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity. Nature Commun, 2018; 9(1): 1-15.
  • Knudsen KB, Northeved H, Kumar PE, Permin A, Gjetting T, Andresen TL et al. In vivo toxicity of cationic micelles and liposomes. Nanomed, ; 11(2): 467-77.
  • Costamagna F, Hillaireau H, Vergnaud- Gauduchon J, Jamgotchian L, Loreau O, Denis S et.al. Nanotoxicology at the particle/micelle frontier: Influence of core-polymerization on the intracellular distribution, cytotoxicity and genotoxicity of polydiacetylene micelles. Nanoscale, 2020; 12: 2452-63.
  • Soodvilai S, Tipparos W, Rangsimawong W, Patrojanasophon P, Soodvilai S, Sajomsang W et.al. Effects of silymarin-loaded amphiphilic chitosan polymeric micelles on the renal toxicity and anticancer activity of cisplatin. Pharm Develop Technol, 2019; 24(8): 927-34.
  • Patil P, Harak K, Saudagar R. The solid lipid nanoparticles, a review. JDDT, 2019; 9(3): 525
  • Patrick S, Eric DS, Anthony WC. A first approach to the study of calixarene solid lipid nanoparticle (SLN) toxicity. J Incl Phenom Macrocycl Chem, ; 46(3-4): 175-7.
  • Silva AH, Filippin-Monteiro FB, Mattei B, Zanetti-Ramos BG, Creczynski-Pasa TB. In vitro biocompatibility of solid lipid nanoparticles. Sci Total Environ, 2012; 432: 382-8.
  • Albuquerque J, Moura CC, Sarmento B, Reis S. Solid lipid nanoparticles: A potential multifunctional approach towards rheumatoid arthritis theranostics. Molecules, 2015; 20(6): 18.
  • Mendonça MCP, Radaic A, Garcia-Fossa F, Da Cruz-Höfling MA, Vinolo MAR, De Jesus MB. The in vivo toxicological profile of cationic solid lipid nanoparticles. Drug Deliver Translation Res, 2020; (1): 34-42.
  • Derman S, Kızılbey K, Akdeste ZM. Polymeric nanoparticles. Sigma, 2013; 31: 107-20.
  • Ritter D, Knebel J, Niehof M, Loinaz I, Marradi M, Gracia R et.al. In vitro inhalation cytotoxicity testing of therapeutic nanosystems for pulmonary infection. Toxicol in Vitro, 2020; : 104714.
  • Yıldırımer L, Thanh N, Loizidoua M, Seifalian MA. Toxicological considerations of clinically applicable nanoparticles. Nano Today, 2011;
  • Hering I, Eilebrecht E, Parnham MJ, Günday- Türeli N, Türeli AE, Weiler M et.al. Evaluation of potential environmental toxicity of polymeric nanomaterials and surfactants. EnvironToxicol Pharmacol, 2020; 76: 103353.
  • Karabulut B, Kerimoğlu O, Uğurlu T. Dendrimerler-ilaç taşıyıcı sistemler. MÜSBED, ; 1(1): 31-40. Jain K, Kesharwani P, Gupta U, Jain NK. Dendrimer toxicity: Let’s meet the challenge. Int J Pharm, 2010; 394(1-2): 122-42.
  • Wang Y, Li C, Du L, Liu Y. A reactive oxygen species-responsive dendrimer with low cytotoxicity for efficient and targeted gene delivery. Chine Chem Lett, 2020; 31(1): 275-80.
  • Jain K, Mehra NK, Jain NK. Nanotechnology in drug delivery: Safety and toxicity issues. Curr Pharm Des, 2015; 21(29): 4252-61.
  • Gorzkiewicz M, Konopka M, Janaszewska A, Tarasenko II, Sheveleva NN, Gajek A et.al. Application of new lysine-based peptide dendrimers D3K2 and D3G2 for gene delivery: Specific cytotoxicity to cancer cells and transfection in vitro. Bioorganic Chem, 2020; : 103-504.
  • Monterio-Riviere NA, Tran CL. Nanotoxicology: Characterization, Dosing and Health Effects. New York: Informa Healthcare, 2007.
  • Lee KC, Lo PY, Lee GY, Zheng JH, Cho EC. Carboxylated carbon nanomaterials in cell cycle and apoptotic cell death regulation. J Biotechnol, 2019; 296: 14-21.
  • Nahle S, Safar R, Grandemange S, Foliguet B, Lovera-Leroux M, Doumandji Z et.al. Single wall and multiwall carbon nanotubes induce different toxicological responses in rat alveolar macrophages. J App Toxicol, 2019; 39(5): 764
  • Siegrist KJ, Reynolds SH, Porter DW, Mercer RR, Bauer AK, Lowry D, Salisbury JL. Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells. Particle Fibre Toxicol, ; 16(1): 36.
  • Zhao X, Chang S, Long J, Li J, Li X, Cao Y. The toxicity of multi-walled carbon nanotubes (MWCNTs) to human endothelial cells: The influence of diameters of MWCNTs. Food Chem Toxicol, 2019; 126: 169-77.
  • Requardt H, Braun A, Steinberg P, Hampel S, Hansen T. Surface defects reduce carbon nanotube toxicity in vitro. Toxicol in Vitro, ; 60: 12-8.
  • Liu Y, Jiang H, Liu C, Ge Y, Wang L, Zhang B et.al. Influence of functional groups on toxicity of carbon nanomaterials. Atmosph Chem Physics, 2019; 19(12): 8175-87.
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There are 67 citations in total.

Details

Primary Language Turkish
Journal Section Collection
Authors

Özge Marangoz This is me

Oğuzhan Yavuz This is me

Publication Date December 1, 2020
Published in Issue Year 2020 Volume: 77 Issue: 4

Cite

APA Marangoz, Ö., & Yavuz, O. (2020). Nano-ilaç taşıma sistemleri ve toksikolojik değerlendirmeleri. Türk Hijyen Ve Deneysel Biyoloji Dergisi, 77(4), 509-526.
AMA Marangoz Ö, Yavuz O. Nano-ilaç taşıma sistemleri ve toksikolojik değerlendirmeleri. Turk Hij Den Biyol Derg. December 2020;77(4):509-526.
Chicago Marangoz, Özge, and Oğuzhan Yavuz. “Nano-Ilaç taşıma Sistemleri Ve Toksikolojik değerlendirmeleri”. Türk Hijyen Ve Deneysel Biyoloji Dergisi 77, no. 4 (December 2020): 509-26.
EndNote Marangoz Ö, Yavuz O (December 1, 2020) Nano-ilaç taşıma sistemleri ve toksikolojik değerlendirmeleri. Türk Hijyen ve Deneysel Biyoloji Dergisi 77 4 509–526.
IEEE Ö. Marangoz and O. Yavuz, “Nano-ilaç taşıma sistemleri ve toksikolojik değerlendirmeleri”, Turk Hij Den Biyol Derg, vol. 77, no. 4, pp. 509–526, 2020.
ISNAD Marangoz, Özge - Yavuz, Oğuzhan. “Nano-Ilaç taşıma Sistemleri Ve Toksikolojik değerlendirmeleri”. Türk Hijyen ve Deneysel Biyoloji Dergisi 77/4 (December 2020), 509-526.
JAMA Marangoz Ö, Yavuz O. Nano-ilaç taşıma sistemleri ve toksikolojik değerlendirmeleri. Turk Hij Den Biyol Derg. 2020;77:509–526.
MLA Marangoz, Özge and Oğuzhan Yavuz. “Nano-Ilaç taşıma Sistemleri Ve Toksikolojik değerlendirmeleri”. Türk Hijyen Ve Deneysel Biyoloji Dergisi, vol. 77, no. 4, 2020, pp. 509-26.
Vancouver Marangoz Ö, Yavuz O. Nano-ilaç taşıma sistemleri ve toksikolojik değerlendirmeleri. Turk Hij Den Biyol Derg. 2020;77(4):509-26.