Sitomegalovirüs Enfeksiyonunda Odyolojik Değerlendirme: Olgu Sunumu

Year 2019, Volume: 2 Issue: 3, 23 - 26, 27.12.2019

Tuğba Çalışan Gonca Sennaroğlu Merve Batuk

Abstract

Özet:Sitomegalovirüs (CMV) konjenitalviral enfeksiyonların önemli bir nedenidir. Konjenital CMV enfeksiyonlu olguların %90’ı asemptomatik iken %10’u semptomatiktir. Asemptomatik olgularda görülen en yaygın semptom sensorinöral işitme kaybıdır. Konjenital asemptomatik CMV infeksiyonunda antiviral tedavi rutin olarak önerilmemekte, ancak olguların işitme kaybı gelişimi açısından dikkatli takibi gerekmektedir. Olgumuzda olduğu gibi konjenital CMV enfeksiyonlu yenidoğanlar işitme kaybı açısından araştırılmalı, antiviral tedavi için değerlendirilmeli ve ek engel açısından dikkatli takip edilip rehabilitasyon açısından değerlendirilmelidir.Bu olgu çalışmasının amacı CMV enfeksiyonu tanılanmış ve odyolojik takipleri yapılan bir olgunun sonuçlarını ve takip sürecini raporlamaktır.

Abstract :Cytomegalovirus (CMV) is a common cause of congenitalviral infections. While 90% of the infants with congenital CMV are asymptomatic, remaining 10% infants of are symptomatic. The most important symptom is sensorineural hearing loss in asymptomatic congenital CMV. Anti-viral agents are not routin elyrecommended. However, the patients should be followed upwith brainstem auditory evoked response concerning the risk of hearing loss.Newborns with congenital CMV infection should be investigated for hearing loss, be evaluated for antiviral treatment, and carefully monitored for addition alhangdicapan devaluated for rehabilitation.The aim of the present study is to report the results and follow-upperiodin a child diagnosed with CMV enfection.

Keywords

Sitomegalovirüs, konjenital enfeksiyon, sensörinöral işitme kaybı, yenidoğan.

References

• 1. Baley JE, Toltzis P. Perinatalviralinfections. In: Martin RJ, Fanaroff AA, Walsh MC, editors. FanaroffandMartin’sNeonatalPerinatalMedicineDiseases of theFetusandInfant. Philadelphia, MosbyElsevier 2006; 840-882.
• 2. Barbi M, Binda S, Caroppo S, et al. MulticityItalianstudy of congenitalcytomegalovirusinfection. Pediatr InfectDis J 2006: 25: 156-9.
• 3. General recommendations on immunization. Recommendations of theAdvisoryCommittee on ImmunizationPractices (ACIP). MMWR RecommRep 1994: 43: 1-38.
• 4. Stagno S, Britt W. CytomegalovirusInfections. In: Remington SS, Klein JO, Wilson CB, Baker CJ, eds. InfectiousDiseases of theFetusandNewbornInfant. 6th ed. Philadelphia, PA, IL: ElsevierSaunders; 2006: 739-781.
• 5. Committee on InfectiousDiseases, AmericanAcaclemy of Pediatrics: Cytomegalovirusinfection. in: Peter G (ed.), 1994 RedBook: Report of Committee on InfectiousDiseases, Twentythirdedition, AmericanAcaclemy of Pecliatrics, ElkGroveVillage, 1994, 173-177.
• 6. Alford CA, Stagno S, Pass RF, Britt WJ: Congenitalandperinatalcytomegalo virüs infections. RevInfectDis, 12 suppl 7: S 745-753, 1990.
• 7. Boppana SB, Pass RF, Britt WJ, et al.:Symptomaticcongenialcytomegalovirusinfection: neonatalmorbidityandmortality. Pediatr InfectDis J, 11 (2): 93-99, 1992.
• 8. Bale JF, Murph JR: Congenitalinfectionsandthenervoussystem. Pediatr Clin North Anı, 39 (4): 669-690, 1992.
• 9. Grose C: Viralinfections of the fetüs andnewborn. in: Behrman RE, Kliegman RM, Arvin AM (ed.), Nelson Textbook of Pediatrics, 15th edition, WB SaunclersCompany, Philaclelphia 1996, 523.
• 10. Michaels MG. Treatment of congenitalcytomegalovirus: wherearewenow? ExpertRev Anti InfectTher 2007; 5(3):441-448.
• 11. Schleiss MR. Antiviraltherapy of congenitalcytomegalovirusinfection. Semin Pediatr InfectDis 2005; 16(1):50-59.
• 12. Janner D. Çocuk Enfeksiyon Hastalıkları Klinik Rehberi. Kara A (Çeviri Editörü). İstanbul: Nobel Tıp Kitapevleri 2008.
• 13. Gali L, Novelli A, Chiappini E, Gervaso P, Cassetta MI, Fallani S, et al. Valganciclovirforcongenital CMV infection: a pilot study on plasmaconcentration in newbornsandinfants. Pediatr InfectDis J 2007; 26(5):451-453.
• 14. Morton CC, Nance WE. Newbornhearingscreening--a silentrevolution. N Engl J Med. 2006;354(20):2151–64.
• 15. Fowler KB, McCollister FP, Dahle AJ, et al. Progressiveandfluctuatingsensorineuralhearingloss in childrenwithasymptomaticcongenitalcytomegalovirusinfection. J Pediatr. 1997;130(4):624–30.
• 16. Dollard SC, Grosse SD, Ross DS. New estimates of theprevalence of neurologicalandsensorysequelaeandmortalityassociatedwithcongenitalcytomegalovirusinfection. RevMedVirol. 2007;17:355–63.