Endometrium kanserinde hormon reseptölerinin prognostik önemi

Abstract

Amaç: Endometrium kanseri (EK) kadın üreme sisteminde Avrupa’da en sık beşinci sırada yer alan ve ölüme sebep olan kanserdir. Hormon reseptörleri (HR) endometrium fizyolojisinde ana modülatörlerindendir. Bu çalışmanın amacı Östrojen reseptörü (ÖR) ve progesterone reseptörünün (PR) opera olan FIGO ever 3 EK olgularında prognostik önemini belirlemektir. Gereç ve Yöntemler: Bu çalışma tek merkezli retrospektif bir çalışma olarak tasarlandı. ÖR ve PR durumları hasta kayıtlarından incelendi. Çalışmanın birinci sonlanım noktası hormon reseptör durumlarının hastalıksız sağ kalım (HSK) ve genel sağ kalım (GSK) olan etkilerini incelemekti. Bulgular: Mevcut çalışmada Ocak 2015 ile Ekim 2021 arasında 113 hasta tarandı. ÖR pozitifliği GSK analizi arasında istatistiki bir anlamlılık görüldü. (HR: 1.40 p:0.005 ve HR:2.173 p: 0.047). PR pozitiflik durumu hem HSK hem de GSK arasında istatistiki bir anlamlılığa ulaşamadı. (HR: 1.80 p:0.09 ve HR: 1.72, p: 0.062 sırasıyla). ÖÖR pozitif hastalarında ortanca HSK ve GSK sırasıyla 58 ay (51-64) ve 129 ay (88-169) olarak görülürken (p<0.0001), ÖR negatif hastalarda sırasıyla 19 ay (17-20) ve 28 ay (23-32) olarak gözlemlendi (p<0.000). Sonuç: ÖR pozitif FIGO evre 3 hastaların hem HSK hem de GSK’ları daha iyi olması ÖR’ nün iyi bir prognostik gösterge olduğunu göstermektedir. FIGO evre 3'teki hastaları sınıflandırmak için ÖR pozitifliği kullanılabilir ve ÖR negatif olan hastalarda yakın takip gerekebilir.

Keywords

• Endometrium kanseri
• östrojen reseptörü
• progesteron reseptörü
• FIGO evre 3
• hastalıksız sağ kalım

Prognostic Role of Hormone Status in Endometrium Cancer

Abstract

Aim: Endometrial carcinoma (EC) is the most common female reproductive system cancer in Europe and fifth leading reason of death in female cancer in worldwide. Hormone receptors are the main modulator of endometrium functions. Aim of present study was to evaluate prognostic indicator Estrogen receptors (ER) and progesterone receptor (PR) in patients at FIGO stage 3 EC. Material and Methods: This study was designed as retrospective one institution analysis. ER status and PR status was enrolled from medical records of patients. Primary endpoint of this study was effect of hormone status to the disease-free survival (DFS) and overall survival (OS). Results: Present study enrolled 133 patients from January 2015 to October 2021. ER and hormone positivity were statistically significant in OS analysis (HR: 1.40 p:0.005 and HR:2.173 p: 0.047). PR status was insignificant statistically in both DFS and OS survival analysis (HR: 1.80 p:0.09 and HR: 1.72, p: 0.062 respectively). The median DFS and OS were 58 months (51-64) and 129 months (88-169) patients with ER positive tumor respectively (p<0.0001), whereas 19 months (17-20) and 28 months (23-32) patients with ER negative tumor (p<0.000). Conclusion: ER positivity was with better DFS and OS and was significantly good prognostic indicator in patients with FIGO stage 3. ER positivity may be used to stratify patients in FIGO stage 3 and close follow-up may be needed in patients in ER negative.

Keywords

• Endometrial carcinoma
• estrogen receptors
• progesterone receptors
• FIGO stage 3
• disease-free survival
• overall survival

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