Can fecal zonulin be used as a biomarker in the detection of leaky bowel syndrome in patients with intestinal metaplasia? A prospective cross-sectional study

Abstract

Abstract: Aim: Intestinal metaplasia is the most common finding in routine endoscopic studies. The relationship between intestinal metaplasia and intestinal dysbiosis and leaking intestine is now a known fact. In this study, we tried to show the detection of this chain of events, which may cause many diseases, with zonulin in stool, which is a non-invasive method. Material and Method: Endoscopy was performed on 20 patients with dyspeptic complaints as of January 2022. All patients were tested for zonulin in the stool using the Stool Sample Application System (SAS) and Elisa method. Endoscopic findings of the patients (intestinal metaplasia, atrophic gastritis, helicobacter (Hp) status) and zonulin values in the stool were examined. This study was designed as a prospective cross-sectional study. Results: The median age of the patients was 48.35 (December: 33-73). In this study, 40% of the patients were female and 60% were male. Of the 20 patients who underwent endoscopy, 14 had intestinal metaplasia (70%), 11 had atrophic gastritis (55%) and 14 had helicobacter (Hp). In our results, while zonulin was high in stool in all patients with these conditions, only statistical significance was observed between intestinal metaplasia and zonulin elevation. Conclusion: Zonulin excretion has increased in fecal excretion in cases with intestinal metaplasia and may be an important marker in these cases.

Keywords

• zonulin
• intestinal permeability
• atrophic gastritis
• intestinal metaplasia

İntestinal metaplazili hastalarda sızdıran bağırsak sendromu tespitinde fekal zonulin biomarker olarak kullanılabilir mi?: prospektif kesitsel çalışma

Abstract

Amaç: intestinal metaplazi, rutin endoskopik çalışmalarda en sık görülen bulgudur. İntestinal metaplazi ile bağırsak disbiyozu ve sızdıran bağırsak arasındaki ilişki artık bilinen bir gerçektir. Biz bu çalışmamızda bir çok hastalığa neden olabilen bu olaylar zincirini non invazif yöntem olan gaitada zonulin ile tespitini göstermeye çalıştık. Materiyal ve Metod : Ocak 2022 den itibaren dispeptik şikayetleri olan 20 hastaya endoskopi yapıldı.. Hastaların hepsinden, Stool Sample Application System (SAS) ve Elisa yöntemi ile gaitada zonulin bakıldı. Hastaların endoskopik bulguları (intestinal metaplazi, atrofik gastrit, helicobakter(Hp) durumu) ile gaitada zonulin değerleri incelendi. Prospektif kesitsel çalışma olarak dizayn edildi. Bulgular: Hastaların median yaşı 48.35( Aralık:33-73) ti. Hastaların %40 ı kadın %60 ı erkekti. Endoskopi yapılan 20 hastadan, 14 hastada intestinal metaplazi (%70), 11 hastada atrofik gastrit (%55) ve 14 hastada helikobakter (Hp) saptadık. Sonuçlarımızda bu durumların var olduğu tüm hastalarda gaitada zonulin yüksek saptanırken, sadece intestinal metaplazi ile zonulin yüksekliği arasında istatistiksel anlamlılık gözlenmiştir. Sonuç: Zonulin atılımı intestinal metaplazili olgularda dışkıda atılımı artmıştır ve bu olgularda önemli bir belirteç olabilir.

Keywords

• zonulin
• bağırsak geçirgenliği
• atrofik gastrit
• intestinal metaplazi

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