Yaşlı erişkin hastalarda Helicobacter pylori eradikasyon başarısı ile non-alkolik yağlı karaciğer hastalığı arasındaki ilişki

Abstract

Amaç: Bu çalışmanın amacı yaşlı erişkin popülasyonda H. pylori eradikasyonunun non-alkolik yağlı karaciğer hastalığı ( NAYKH) eradikasyonu üzerindeki etkisini göstermekti. Gereç ve Yöntemler: Çalışmaya alınan hastalar 65 yaş ve üstü yaşlı erişkin grubu ve 65 yaş altı genç erişkin grubu olarak iki gruba ayrıldı. H.pylori eradikasyonu için tüm hastalara gemifloksasin 320mg/gün, amoksisilin 2 gr/gün ve rabeprazol 40 mg/gün tedavisi uygulandı. Karaciğer yağlanması hepatobiliyer ultrasonografi ile değerlendirildi ve derece 1, 2 veya 3 olarak sınıflandırıldı. Bulgular: Endoskopik ve histopatolojik olarak HP enfeksiyonu saptanan ve tedavi edilen 271 hasta değerlendirmeye alındı. Yaşlı erişkin grupta 54 (%79.4) hastada başarılı HP eradikasyonu sağlandı.İleri yaş grubunda karaciğer yağlanması varlığı ile HP eradikasyonu başarısı arasında istatistiki olarak anlamlı bir ilişki gözlenmedi (p>0,05) Sonuç: NAYKH ve HP arasındaki bilinen ilişki ileri yaştaki hastalarda daha fazla önem taşımaktadır.

Keywords

• Helicobacter pylori
• non-alkolik yağlı karaciğer
• yaşlı erişkin

Association between eradication success of Helicobacter pylori with presence of non-alcoholic fatty liver disease in older adult patients

Abstract

Aim: The aim of this study was to show the effect of H. pylori eradication on the eradication of non-alcoholic fatty liver disease (NAFLD) in the older adult population. Material and Methods: The patients included in the study were separated into two groups as the older adult group aged ≥65 years and the young adult group aged <65 years. Treatment of gemifloxacin 320mg/day, amoxicillin 2 gr/day, and rabeprazole 40 mg/day was administered to all the patients for the eradication of H.pylori. Hepatic steatosis was evaluated with hepatobiliary ultrasonography and was classified as grade 1, 2, or 3. Results: Evaluation was made of 271 patients who were determined endoscopically and histopathologically with HP infection and treated accordingly. Successful HP eradication was achieved in 54 (79.4%) patients in the older adult group. In the examination of the relationship between fatty liver and HP eradication after treatment in the older age group, no significant relationship was observed between the presence of hepatosteatosis and HP eradication (p>0.05) Conclusion: The known relationship between NAFLD and HP is of greater importance in patients of advanced age

Keywords

• Helicobacter pylori
• non-alcoholic fatty liver
• older adult

Supporting Institution

yok

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