The importance of monitoring of CEA and CA 15-3 levels in patients with stageIII-B breastcancer

Abstract

Aim: 10-15% of breast cancer is locally advancedbreastcancer at the time of initial diagnosis. Intergroup of tumor markers in breast cancer, carcinoembryonic antigen (CEA) andcancerantigen 15-3 (CA 15-3) are of great importance. Inthisstudy,we tried to reveal the relationshipbetweentumormarkers in stage IIIB breastcancerwithlocalrecurrenceanddistant organ metastasis in the follow-up of patients. Material and Methods: 140 patientswithstage IIIB breastcancerwhowereadmitted to Ankara OncologyHospitalwithin4yearsandwereoperableafterneoadjuvantchemotherapywhere retrospectively analyzed. Results: 140 patientswereincluded in thestudy. At the time of application, CEA levelwaswithinthe normal range in 54 (38.5%), the CA 15-3 levelwaswithinthe normal range in 72 (51.4%). Afterchemotherapyand in 60 (69.7%) of thesepatients, the CEA levelswere normal. In 46 (67.6%) of them, CA 15-3 levelwaswithin normal limits. The rate of decrease in CEA levelandthe rate of decrease in CA 15-3 levelafterchemotherapywas<0.05, and it wassignificant. CA 15-3 levelswerenormalized in 116 (82.8%) of thepatients. Duringthe 3-year follow-up period of 48 patientswithlocal recurrence, 26 (54.1%) had high CEA levels, 33 (68.7%) had high CA 15-3 levels, and 37 (77%) had high CEA or CA 15-3. Conclusion:Wefound that the probability of occurrence of localrecurrenceand / or distant organ metastasisincreasedsignificantlyafter 4-6 months in patientswhosetumor marker levelswereincreased in thepostoperativefollow-upperiod.duringthepostoperativefollow-upperiod.

Keywords

• Breastcancer
• advanced stage
• CEA
• CA 15-3
• local recurrence
• distant metastasis

Evre III-B meme kanserli hastalarda CEA ve CA 15-3 düzeylerinin takipteki önemi

Abstract

Amaç: Meme kanserinin ilk tanıda%10-15'i lokal ileri meme kanseridir. Meme kanserinde tümör belirleyicileri grubunda karsinoembriyonik antijen (CEA) ve kanser antijeni 15-3 (CA 15-3) büyük önem taşır. Biz bu çalışmada evre IIIB meme kanserlerinde tümör belirleyicilerinin hastaların takibinde lokal nüks ve uzak organ metastaz ile ilişkisini ortaya koymaya çalıştık. Gereç ve Yöntemler: Ankara Onkoloji Hastanesi'ne 4 yıllık süre içerisinde başvuran evre IIIB meme kanseri olup neoadjuvan kemoterapi sonrası operabl olan 140 hasta retrospektif olarak incelendi. Bulgular: Çalışmaya 140 hasta dahil edildi. Başvuru anında; 54'ünde (%38,5) CEA düzeyi normal sınırlarda iken, CA 15-3 düzeyi 72'sinde (%51,4) normal sınırlarda idi. Kemoterapi sonrası ve bu hastaların 60’ında (%69,7) CEA düzeyleri normal, 46'sında (%67,6) CA 15-3 düzeyi normal sınırlarda idi. Kemoterapi sonrası CEA düzeyindeki düşüş oranı ile CA 15-3 düzeyindeki düşüş oranı p'ye göre <0,05 olup anlamlı bulunmuştur. Hastaların 116'sında (%82,8) CA 15-3 düzeyleri normalleşti. 3 yıllık takip süresinde lokal nüksü olan 48 hastanın 26'sında (%54,1) CEA düzeyi yüksek, 33'ünde (%68,7) CA 15-3 düzeyi yüksek, 37 'sinde (%77) ise CEA veya CA 15-3’ten herhangi birisinde yüksek değer saptandı. Sonuç: Postoperatif takip döneminde tümör belirleyici düzeylerinde artış oluşan hastalarda 4-6 ay sonrasında lokal nüksün ve/veya uzak organ metastazının ortaya çıkması ihtimalinin anlamlı olarak arttığını bulduk.

Keywords

• Meme kanseri
• ileri evre
• CEA
• CA 15-3
• lokal nüks
• uzak metastaz

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