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Kolorektal kanserli hastaların demografik özellikleri

Year 2024, , 376 - 382, 30.09.2024
https://doi.org/10.18663/tjcl.1455652

Abstract

Amaç: Kolorektal kanserler, kanserle ilgili mortalite ve morbiditenin en önemli sebeplerindendir. Tüm dünyada erkeklerde tanı alan en sık 3., kadınlarda ise en sık 2. kanserdir. Kolon kanseri erkek ve kadında hemen hemen eşit görülürken, rektal kanser erkeklerde K:E = 1:1.3 oranında daha sık görülür. Medyan tanı yaşı 70 olan kolorektal kanserler 50 yaş altında nadir görülür. Kolorektal tanısı ile takipli hastaların genel nitelikleri ve bu niteliklerin literatür ile uyumlu olup olmadığı araştırıldı.
Gereç ve Yöntemler: Çalışma, kesitsel, retrospektif kohort çalışması olarak tasarlandı. Temmuz 2011- Eylül 2015 tarihleri arasında Ankara Dışkapı Eğitim ve Araştırma Hastanesi Onkoloji Kliniği’nde takip edilen, kolonoskopi yapılarak tanısı konulan ve histopatolojik olarak tanısı doğrulanan kolorektal kanserli vakalar değerlendirildi.
Sonuç: Çalışmaya evre I-IV kolorektal kanserli 172 hasta alındı ve genel nitelikleri değerlendirildi. Hastalık literatür ile uyumlu şekilde erkek cinsiyette kadınlara göre daha sık tespit edildi Hastaların medyan yaşı 62 olarak saptandı. En genç hasta 27, en yaşlı hasta ise 89 yaşındaydı. KRK tanısıyla takip edilen erkek hastaların %37’sinde daha çok rektum kanserleri, %61’inde daha proksimal yerleşimli kolon kanserleri görülürken, kadınlarda %36 oranında rektum kanserleri ve buna yakın olarak %38 oranında daha proksimal yerleşimli kolon kanserleri görüldüğü saptanmıştır. Bu çalışmamız ile dünyada olduğu gibi ülkemizde de önemli morbidite ve mortalite nedenlerinden biri olan kolorektal kanserlerin demografik yapısını ve risk faktörlerini belirleyerek literatüre katkı sağlamayı amaçladık.

References

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  • Doubeni, C.A., et al., Socioeconomic status and the risk of colorectal cancer: an analysis of more than a half million adults in the National Institutes of Health‐AARP Diet and Health Study. Cancer, 2012. 118(14): p. 3636-3644.
  • Siegel, R.L., et al., Colorectal cancer statistics, 2023. CA: a cancer journal for clinicians, 2023. 73(3): p. 233-254.
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  • Rothwell, P.M., et al., Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. The Lancet, 2011. 377(9759): p. 31-41.
  • Siegel, R.L., K.D. Miller, and A. Jemal, Cancer statistics, 2018. CA: a cancer journal for clinicians, 2018. 68(1): p. 7-30.
  • Shepherd, N.A., K.J. Baxter, and S.B. Love, The prognostic importance of peritoneal involvement in colonic cancer: a prospective evaluation. Gastroenterology, 1997. 112(4): p. 1096-1102.
  • Feig, B.W., D.H. Berger, and G.M. Fuhrman, The MD Anderson surgical oncology handbook. 2006: Lippincott Williams & Wilkins.
  • Edge, S.B. and A.J.C.o. Cancer, AJCC cancer staging manual. Vol. 7. 2010: Springer.
  • Benson, A.r., et al., American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. Journal of clinical oncology, 2004. 22(16): p. 3408-3419.
  • Schmoll, H., et al., ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making. Annals of oncology, 2012. 23(10): p. 2479-2516.
  • Quah, H.-M., et al., Identification of patients with high-risk stage II colon cancer for adjuvant therapy. Diseases of the colon & rectum, 2008. 51: p. 503-507.

Demographic characteristics of patients with colorectal cancer

Year 2024, , 376 - 382, 30.09.2024
https://doi.org/10.18663/tjcl.1455652

Abstract

Aim: Colorectal cancers are one of the most important causes of cancer-related mortality and morbidity. It is the 3rd most common cancer diagnosed in men and the 2nd most common cancer diagnosed in women worldwide. While colon cancer is almost equally seen in men and women, rectal cancer is more common in men with a ratio of F:M = 1:1.3. Colorectal cancers are rare below the age of 50 years with a median age at diagnosis of 70 years. The aim was to investigate the general characteristics of patients diagnosed with colorectal cancer under follow-up, whether these characteristics are consistent with the literatüre or not.
Material and Methods: The study was designed as a cross-sectional, retrospective cohort study. Patients diagnosed with colorectal cancer, who were followed up at the Oncology Clinic of Ankara Dışkapı Training and Research Hospital and whose diagnosis was confirmed by colonoscopy and histopathological examination, were evaluated between July 2011 and September 2015.
Results: The study included 172 patients with stage I-IV colorectal cancer and their general characteristics were evaluated. The disease was found to be more common in the male sex than in the female sex in accordance with the literature. The median age of the patients was 62 years. The youngest patient was 27 years old and the oldest patient was 89 years old. It was found that 37% of male patients with CRC had rectal cancers and 61% had more proximal colon cancers, whereas 36% of female patients had rectal cancers and 38% had more proximal colon cancers. With this study, we have shown that colon cancers are a major cause of morbidity and mortality in our country as well as in the World

References

  • Pickhardt, P.J., et al., Colorectal cancer: CT colonography and colonoscopy for detection—systematic review and meta-analysis. Radiology, 2011. 259(2): p. 393-405.
  • Organization, W.H., Global Cancer Observatory. International Agency for Research on Cancer. (Accessed on January 23, 2023).
  • Clancy, E., ACS Report Shows Prostate Cancer on the Rise, Cervical Cancer on the Decline. Renal & Urology News, 2023: p. NA-NA.
  • Müdürlüğü, T.S.B.H.S.G., Türkiye Kanser İstatistikleri. 2018.
  • Eddy, D.M., Screening for colorectal cancer. Annals of Internal Medicine, 1990. 113(5): p. 373-384.
  • Botteri, E., et al., Smoking and colorectal cancer: a meta-analysis. Jama, 2008. 300(23): p. 2765-2778.
  • Karahalios, A., D.R. English, and J.A. Simpson, Weight change and risk of colorectal cancer: a systematic review and meta-analysis. American journal of epidemiology, 2015. 181(11): p. 832-845.
  • Doubeni, C.A., et al., Socioeconomic status and the risk of colorectal cancer: an analysis of more than a half million adults in the National Institutes of Health‐AARP Diet and Health Study. Cancer, 2012. 118(14): p. 3636-3644.
  • Siegel, R.L., et al., Colorectal cancer statistics, 2023. CA: a cancer journal for clinicians, 2023. 73(3): p. 233-254.
  • Schoenfeld, P., et al., Colonoscopic screening of average-risk women for colorectal neoplasia. New England Journal of Medicine, 2005. 352(20): p. 2061-2068.
  • Tuohy, T.M., et al., Risk of colorectal cancer and adenomas in the families of patients with adenomas: A population‐based study in Utah. Cancer, 2014. 120(1): p. 35-42.
  • Ahsan, H., et al., Family history of colorectal adenomatous polyps and increased risk for colorectal cancer. Annals of internal medicine, 1998. 128(11): p. 900-905.
  • Rothwell, P.M., et al., Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. The Lancet, 2011. 377(9759): p. 31-41.
  • Siegel, R.L., K.D. Miller, and A. Jemal, Cancer statistics, 2018. CA: a cancer journal for clinicians, 2018. 68(1): p. 7-30.
  • Shepherd, N.A., K.J. Baxter, and S.B. Love, The prognostic importance of peritoneal involvement in colonic cancer: a prospective evaluation. Gastroenterology, 1997. 112(4): p. 1096-1102.
  • Feig, B.W., D.H. Berger, and G.M. Fuhrman, The MD Anderson surgical oncology handbook. 2006: Lippincott Williams & Wilkins.
  • Edge, S.B. and A.J.C.o. Cancer, AJCC cancer staging manual. Vol. 7. 2010: Springer.
  • Benson, A.r., et al., American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. Journal of clinical oncology, 2004. 22(16): p. 3408-3419.
  • Schmoll, H., et al., ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making. Annals of oncology, 2012. 23(10): p. 2479-2516.
  • Quah, H.-M., et al., Identification of patients with high-risk stage II colon cancer for adjuvant therapy. Diseases of the colon & rectum, 2008. 51: p. 503-507.
There are 20 citations in total.

Details

Primary Language Turkish
Subjects Clinical Oncology
Journal Section Research Article
Authors

Özlem Karakaş 0000-0002-3031-3353

Abdulsamet Erden 0000-0002-8084-2018

Özlem Aydın İsak 0000-0003-4082-4867

Gökşen İnanç İmamoğlu 0000-0003-0356-0727

Sanem Kayhan 0000-0001-7736-2681

Publication Date September 30, 2024
Submission Date March 19, 2024
Acceptance Date August 6, 2024
Published in Issue Year 2024

Cite

APA Karakaş, Ö., Erden, A., Aydın İsak, Ö., İmamoğlu, G. İ., et al. (2024). Kolorektal kanserli hastaların demografik özellikleri. Turkish Journal of Clinics and Laboratory, 15(3), 376-382. https://doi.org/10.18663/tjcl.1455652
AMA Karakaş Ö, Erden A, Aydın İsak Ö, İmamoğlu Gİ, Kayhan S. Kolorektal kanserli hastaların demografik özellikleri. TJCL. September 2024;15(3):376-382. doi:10.18663/tjcl.1455652
Chicago Karakaş, Özlem, Abdulsamet Erden, Özlem Aydın İsak, Gökşen İnanç İmamoğlu, and Sanem Kayhan. “Kolorektal Kanserli hastaların Demografik özellikleri”. Turkish Journal of Clinics and Laboratory 15, no. 3 (September 2024): 376-82. https://doi.org/10.18663/tjcl.1455652.
EndNote Karakaş Ö, Erden A, Aydın İsak Ö, İmamoğlu Gİ, Kayhan S (September 1, 2024) Kolorektal kanserli hastaların demografik özellikleri. Turkish Journal of Clinics and Laboratory 15 3 376–382.
IEEE Ö. Karakaş, A. Erden, Ö. Aydın İsak, G. İ. İmamoğlu, and S. Kayhan, “Kolorektal kanserli hastaların demografik özellikleri”, TJCL, vol. 15, no. 3, pp. 376–382, 2024, doi: 10.18663/tjcl.1455652.
ISNAD Karakaş, Özlem et al. “Kolorektal Kanserli hastaların Demografik özellikleri”. Turkish Journal of Clinics and Laboratory 15/3 (September 2024), 376-382. https://doi.org/10.18663/tjcl.1455652.
JAMA Karakaş Ö, Erden A, Aydın İsak Ö, İmamoğlu Gİ, Kayhan S. Kolorektal kanserli hastaların demografik özellikleri. TJCL. 2024;15:376–382.
MLA Karakaş, Özlem et al. “Kolorektal Kanserli hastaların Demografik özellikleri”. Turkish Journal of Clinics and Laboratory, vol. 15, no. 3, 2024, pp. 376-82, doi:10.18663/tjcl.1455652.
Vancouver Karakaş Ö, Erden A, Aydın İsak Ö, İmamoğlu Gİ, Kayhan S. Kolorektal kanserli hastaların demografik özellikleri. TJCL. 2024;15(3):376-82.


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