Çölyak hastalığı ile ilişkili sistemik enflamasyonun değerlendirilmesi

Abstract

Amaç: Çalışmanın nihai amacı, çölyak hastalığında sistemik inflamasyonu ölçmek ve ilişkili parametreleri belirlemek, böylece Çölyak Hastalığı'nda (ÇH) sistemik inflamasyonla mücadele ederek sistemik yan etkileri önlemektir. Gereç ve Yöntemler: 2015-2025 yılları arasında merkezlerimizin Dahiliye Kliniklerine başvuran ÇH tanılı hastalar ve başka nedenlerle değerlendirilen ÇH tanısı olmayan, sağlıklı bireylerde Sistemik İnflamatuar İndeks (Sİİ) “trombosit sayısı × nötrofil sayısı/lenfosit sayısı” olarak hesaplandı. Demografik özellikler, Anti-doku transglutaminaz (Anti-TTG), anti-gliadin, insan lökosit antijenleri olan HLADQB102, HLADQA103, HLADQA105, hemogram, eritrosit sedimentasyon hızı (ESR), C-reaktif protein (CRP) değerleri hastane kayıt sisteminden alınmıştır Bulgular: 102 CD hastası ve 98 kontrol grubu olarak toplam 200 katılımcı çalışmaya dahil edilmiştir. Kohortun %60,1'ini kadınlar oluşturmuştur. Ortalama Sİİ değeri ÇH hastalarında 636,06 ve kontrol grubunda 466,48 olup istatistiksel olarak anlamlı bir fark bulunmamıştır (p = 0,037). Sİİ ile otoantikor veya genetik belirteçler arasında korelasyon gözlenmemiştir. Hemoglobin ve trombosit düzeyleri gruplar arasında anlamlı farklılık göstermiştir (p = 0,011 ve p = 0,001). Sİİ, ESR ve hemoglobin ile güçlü bir pozitif korelasyon ve CRP ile zayıf bir korelasyon gösterdi. Sonuçlar: Sİİ, CD hastalarında daha yüksek bulunmuş olmasına rağmen, serolojik veya genetik belirteçlerle anlamlı bir ilişki göstermemiştir. Sİİ, geleneksel belirteçlerin ötesinde ÇH'deki sistemik inflamasyonu yansıtıyor olabilir. Tanı ve izlemdeki rolünü netleştirmek için daha ileri prospektif çalışmalara ihtiyaç vardır.

Keywords

• Çölyak hastalığı
• inflamasyon
• sistemik inflamatuvar indeks

Ethical Statement

Bu çalışma, Yozgat Bozok Üniversitesi Girişimsel Olmayan Klinik Araştırmalar Etik Kurulu tarafından 2025-GOKAEK-257_2025.04.09_456 numaralı karar ile onaylanmıştır.

Evaluation of Systemic Inflammation Associated with Celiac Disease

Abstract

Aim: The ultimate goal of the study is to measure systemic inflammation in celiac disease and identify associated parameters, thus preventing systemic side effects by combating systemic inflammation in Celiac Disease (CD). Material and Methods: The Systemic Inflammatory Index (SII) was calculated as “platelet count × neutrophil count/lymphocyte count” in patients with CD and healthy individuals without a diagnosis of CD who were evaluated for other reasons, who applied to the Internal Medicine Clinics of our centers between 2015-2025. Demographic characteristics, Anti-tissue transglutaminase (Anti-TTG), anti-gliadin, Human leucocyte antigenes HLADQB102, HLADQA103, HLADQA105, hemogram, ESR, CRP, and routine biochemical markers were extracted from medical records. Results: A total of 200 participants were included: 102 CD patients and 98 controls. Females constituted 60.1% of the cohort. The mean SII was 636.06 in CD patients and 466.48 in controls, with no statistically significant difference (p = 0.037). No correlation was observed between SII and autoantibody or genetic markers. Hemoglobin and platelet levels differed significantly between groups (p = 0.011 and p = 0.001). SII showed a strong positive correlation with ESR and hemoglobin, and a weak correlation with CRP. Conclusion: Although SII was higher in CD patients, it was not significantly associated with serological or genetic markers. SII may reflect systemic inflammation in CD beyond traditional markers. Further prospective studies are needed to clarify its role in diagnosis and monitoring.

Keywords

• Celiac Disease
• inflammation
• systemic inflammatory index

Ethical Statement

This study is approved by Yozgat Bozok University Non-Interventional Clinical Research Ethics Committee with decision number 2025-GOKAEK-257_2025.04.09_456.

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