Choroidal thickness changes in connective tissue diseases

Abstract

 

Purpose: To evaluate choroidal thickness (CT) changes in connective tissue disease (CTD) using spectral domain optical coherence tomography (SD OCT) with enhanced depth imaging (EDI).

Methods:   In this prospective clinical study, we included 34 subjects who were diagnosed as CTD in remission for at least  3 month and 30 age- and gender-matched healthy controls. Central macular thickness (CMT), subfoveal CT, and CT at nasal (N) and temporal (T) distances of 500 μm (N500 and T500, respectively) and 1500 μm (N500 and T1500, respectively) from the central fovea were measured by EDI OCT  .

Results:  The mean CMT of the patient group (219.2 μm) was thinner compared to the control group (225.5 μm), but the difference was not statistically significant (p = 0.2). At the same time  Mean CT values were thinner  at all measure points in the CTD subjects.  The mean subfoveal CT,N500, N1500, T500and T1500  were not significantly different in comparison to controls (all p>0.05). 

Conclusions: Although our results did not reach statistical significance, we found thinner choroidal tissue  in patients with CTD .

Keywords:Choroidal thickness, connective tissue diseases  

Bağ dokusu hastalıklarında koroidal kalınlık değişikleri

Abstract

Amaç: Çalışmanın amacı bağ dokusu hastalıklarında (BDH) koroid kalınlığı (KK) değişikliklerinin Spektral Domein optik koherens tomografi (SD OKT) kullanılarak değerlendirilmesidir.Gereç ve Yöntemler: Bu prospektif klinik çalışmada, en az 3 aydır remisyonda olan ve bağ dokusu hastalığı tanısı almış 34 hasta ve yaş ve cinsiyet uyumu olan 30 sağlam kişi kontrol grubu olarak değerlendirilmiştir. Santral makula kalınlığı (SMK) subfoveal, nazal ve temporal 500, 1500 mikron mesafelerdeki KK, SD OKT ile ölçülmüştür.Bulgular: Hasta grubunda ortalama SMK (219,2 μm) kontrol grubuna göre (225,5 μm) daha ince bulunmuştur. Ancak aradaki fark istatistiksel olarak anlamlı değildi (P = 0,2). Aynı zamanda ortalama KK her ölçüm noktası için hasta grubunda incelmiş olarak bulunmuştur fakat aradaki fark yine istatistiksel olarak anlamlı değildi (P > 0,05). Sonuçlar: İstatistiksel olarak anlamlı olmamasına rağmen BDH’larında koroid dokusu kalınlığı incelmiş olarak bulunmuştur

Keywords

• Optik koherens tomografi, göz hastalıkları, bağ dokusu hastalıkları, koroidal hastalıklar, klinik çalışma

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