Mantle cell lymphoma of the maxillary sinus: case report

Abstract

Mantle cell lymphoma (MCL) is one of the many subtypes of B-cell lymphoma. Extra nodal involvement is common and most commonly observed in bone marrow, liver, spleen, Waldeyer ring and gastrointestinal tract. As in all malignant lymphomas excisional lymph node biopsy is preferred for diagnosis. In early stage of MCL, radiotherapy is considered to be a suitable treatment approach after 3-4 cycles of systemic chemotherapy. In our case, a fifty-year-old female patient had complaints of swelling and asymmetry on the face, propitosis with dental pain not exceeding 1 month. After radiologic evaluation, maxillary sinus biopsy was reported as Mantle cell lymphoma. In sinonasal MHL, nonspecific symptoms such as nasal obstruction, epistaxis, swelling on the face, rhinitis, visual impairment and proptosis can be seen. The lymphoma should be considered in the different diagnosis of these patients in which the symptoms are nonspecific.

Keywords

• Mantle cell lymphoma,maxillary sinus,B cell tumor

Maksiller sinüsün Mantle hücreli lenfoması: olgu sunumu

Abstract

Mantle hücreli lenfoma (MHL) çok sayıda B-hücreli lenfoma subtiplerinden biridir. Ekstra nodal tutulum sıktır, en sık kemik iliği, karaciğer, dalak, Waldeyer halkası ve gastrointestinal kanal tutulumu gözlenir. Tüm habis lenfomalarda olduğu gibi tanı için eksizyonel lenf düğümü biyopsisi tercih edilir. Erken evre MHL hastalarında 3-4 kür sistemik kemoterapi sonrası radyoterapi uygulaması uygun bir tedavi yaklaşımı olarak görülmektedir. Bizim olgumuzda elli yaşında bayan hastada 1 aydır geçmeyen diş ağrısı ile birlikte yüzde şişlik, asimetri, gözde öne itilme şikayetleri mevcuttu. Radyolojik değerlendirme sonrası maksiler sinüsten alınan biyopsi sonucu Mantle Hücreli Lenfoma olarak bildirildi. Sinonazal MHL’de nazal obstrüksiyon, epistaksis, yüzde şişlik, rinit, görme bozukluğu ve gözde çıkıklık gibi nonspesifik semptomlar görülebilir. Semptomların non spesifik seyrettiği bu hastaların ayırıcı tanısında lenfoma mutlaka düşünülmelidir.

Keywords

• Mantle hücreli lenfoma,maksiler sinüs,B hücreli tümör

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