Evaluation of minimal erythemadose in patients who use dihydropyridinic calcium channel blockers

Abstract

Aim: One of the most frequent and reliable methods for determining phototoxicity is to monitor the minimal erythema dose(MED) related to UVA after using the drug.

In our study, it was aimed to determine whether dihydropyridine-derived calcium channel blockers cause phototoxicity.

Material and Methods: Eight open areas of 1 cm2 were left on the backs of the patients. Eight different doses of UVA were applied to these 8 areas starting at 2 j / cm2 and increasing to 16 j / cm2; After 24 hours, the first area which had significant erythema was checked. This value is defined as minimal erythematous dose (MED). MED values of patients were measured before treatment and on the 7th day of treatment.

Results:Thirty-nine hypertensive patients, 20 female and 19 male, were included in the study.

Conclusion: Dihydropyridine-derived calcium channel blockers did not cause a change in MED for UVA and therefore did not cause phototoxicity.

Keywords

• minimal erythema dose,phototoxicity,nifedipine,calcium channel blocker,amlodipine

Dihidropiriridn Türevi Kalsiyum Kanal Blokeri Kullananlarda Minimal Eritem Dozunun Değerlendirilmesi

Abstract

Amaç: Bir ilaca bağlı fototoksisitenin belirlenmesinde en sık ve güvenilir yöntem ilacı kullanmaya başladıktan sonra özellikle UVA’ya ait minimal eritem dozu (MED) değişimini gözlemektir. Çalışmamızda fotosensitiviteye yol açabileceği belirtilen hipertansiyon ilaçlarından dihidropiridin türevi kalsiyum kanal blokerlerinin fotosensitiviteye sebep olup olmadıklarının saptanması amaçlanmıştır.

Gereç ve Yöntemler: Hastaların sırtlarında 1 cm2 lik 8 adet açık alan bırakılmıştır. Bu 8 alana 2 j/cm2 dozundan başlanarak 16 j/cm2’ye kadar artan 8 farklı dozda UVA uygulanmış; 24 saat sonra ilk hangi alanda sınırları belirgin eritem oluştuğuna bakılmıştır. Bu değer minimal eritem dozu(MED) olarak belirlenmiştir. Hastaların tedavi öncesi ve tedavinin 7. gününde MED değerleri ölçülmüştür.

Bulgular: Çalışmaya 20’si kadın, 19’u erkek olmak üzere 39 hipertansiyon hastası dahil edilmiştir.

Tartışma: Dihidropiridin türevi kalsiyum kanal blokerilerinin UVA için MED değerinde değişiklikliğe neden olmadığı dolayısıyle fototoksisiteye sebep olmadığı görülmüştür.

Keywords

• fototoksisite,kalsiyum kanal blokeri,nifedipin,amlodipin,minimal eritem dozu

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