Diagnostic value of basic laboratory parameters for simple and perforated acute appendicitis

Abstract

Aim: The aim of the present study was to investigate the efficacy of simple laboratory parameters including neutrophil-to-lymphocyte ratio (NLR), leukocyte count (WCC), C-reactive protein (CRP)  and red cell distribution width (RDW) values in both diagnosing simple appendicitis and predicting complicated appendicitis.

Material and Methods: A database of 413 patients who underwent surgery was appreciated. Based on postoperative histopathological examination, the patients were divided into two groups: negative appendectomy (G1) and positive appendectomy (G2). Patients in the positive appendectomy group were further divided into two subgroups: simple appendicitis (G2a) and complicated (gangrenous and perforated) appendicitis (G2b).

Results: WCC and NLR were significant parameters for the diagnosis of acute appendicitis. Cut-off values were 11950/mm³ for WCC (sensitivity: 71.7%; specificity: 50%; OR: 2.53) and 3.7 for NLR (sensitivity: 75.1%; specificity: 42.8%; OR:2.25). WCC, CRP and NLR were independent variables for the diagnosis of complicated appendicitis. Cut-off values were 14450/mm³ for WCC (sensitivity: 66.7%; specificity: 59%; OR: 2.87), 25.5 mg/dl for CRP (sensitivity: 63.8%; specificity: 58.2%; OR: 2.47) and 6.94 for NLR (sensitivity: 61.1%; specificity: 61%; OR: 2.51).

Conclusion:  As a result, preoperative NLR is a useful parameter to aid in the diagnosis of acute appendicitis and differentiate between simple and complicated appendicitis and can be used as an adjunct to the clinical examination.

Keywords

• Appendicitis,neutrophil-to-lymphocyte ratio,laboratory parameters

Basit ve perfore akut apandisit için temel laboratuvar parametrelerinin tanısal değeri

Abstract

Amaç: Bu çalışmanın amacı  nötrofil-lenfosit oranı (NLR), lökosit sayısı (WCC), C-reaktif protein (CRP) ve kırmızı kan hücre dağılım genişliği (RDW) gibi değerleri içeren basit laboratuar parametrelerinin basit apandisit ve komplike apandisit tanısı koyma etkinliğini araştırmaktı.

Gereç ve Yöntemler: Ameliyat edilen 413 hastanın postoperatif histopatolojik incelemesine göre  hastalar negatif apendektomi (G1) ve pozitif apendektomi (G2) olmak üzere iki gruba ayrıldı. Pozitif apendektomi grubundaki hastalar, basit apandisit (G2a) ve komplike (gangrenöz ve perfore) apandisit (G2b) olmak üzere iki alt gruba ayrıldı.

Bulgular: WCC ve NLR akut apandisit tanısında önemli parametrelerdir. Cut-off değerleri WCC için 11950 / mm³ (duyarlılık:% 71.7, özgüllük:% 50; OR: 2.53) ve NLR için 3.7 (duyarlılık:% 75.1, özgüllük:% 42.8; OR: 2.25) bulundu. WCC, CRP ve NLR komplike apandisit tanısında bağımsız değişkenlerdi. Cut-off değerleri WCC için 14450 / mm³ (duyarlılık:% 66.7, özgüllük:% 59; OR: 2.87), CRP için 25.5 mg / dl (duyarlılık:% 63.8; özgüllük:% 58.2; OR: 2.47) ve 6.94 NLR (duyarlılık:% 61.1, özgüllük:% 61; OR: 2.51).

Sonuç: Sonuç olarak preoperatif NLR, akut apandisit tanısında, basit ve komplike apandisitleri ayırt etmede yararlı bir parametredir ve klinik muayene için  yardımcı olarak kullanılabilir.

Keywords

• Apandisit,nötrofil-lenfosit oranı,laboratuvar

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