The relationship between fibrinogen to albumin ratio and carotid artery disease in patients with carotid endarterectomy and patients with non severe carotid artery stenosis

Year 2018, , 321 - 326, 28.12.2018

Kadir Kaan Özsin , Umut Serhat Sanrı , Faruk Toktaş , Şenol Yavuz

https://doi.org/10.18663/tjcl.461635

Cited By: 1

Abstract

Aim: To investigate the relationship
between  fibrinogen to albumin ratio
(FAR) and carotid artery stenosis (CAS).

Material and Methods: This study
included patients who underwent carotid endarterctomy
(CEA) as CEA group and unoperated patients who have CAS  less than 50% as non-surgical group. CAS was
diagnosed with history and physical examination followed by doppler
ultrasonography and carotid angiography. All data retrieved retrospectively
from the hospital medical files. Hematologic parameters were measured and
recorded. In addition, FAR was calculated.

Results: Fifty patients were included
in CEA group (70.0 % male, mean age: 71.0 ± 7.7 years) and 60 patients were
invluded in non-surgical group (70.0 % male, mean age: 63.9 ± 8.0 years). In
logistic regression analysis advanced age, presence of coronary artery disease
and FAR were identified as an independent predictor of
the development of CAS. In Receiver operating characteristic (ROC) curve
analysis, for predicting development of CAS, there were 68.0% sensitivity and
65.0% specificity for FAR (area under the curve [AUC]: 0.669, 95% CI:
0.566-0.771, log rank p = 0.002).

Conclusion: We found that FAR were
identified as an independent predictor of the development of CAS. FAR could be
a potential marker on carotid atherosclerosis in patients. But there is a need
large studies including all cardiovascular diseases.

Keywords

Carotid artery stenosis, fibrinogen, albumin

Karotis endarterektomili ve şiddetli olmayan karotis arter darlığı olan hastalarda fibrinojen / albümin oranı ve karotis arter hastalığı arasındaki ilişki.

Abstract

Amaç: Fibrinojen ile albumin oranı (FAR)
ve karotis arter stenozu (KAS) arasındaki ilişkiyi araştırmak.

Gereç ve Yöntemler: Bu çalışma, karotis
endarterektomisi (KEA) geçiren hastaları ve % 50'den az karotis arter stenozu
olan hastaları içermektedir. KAS tanısı fizik muayene, tıbbi hikaye ve ardından
doppler ultrasonografi ve karotis anjiyografi ile konuldu. Tüm veriler hastane
tıbbi dosyalarından retrospektif olarak alındı. Laboratuvar kan sonuçları ve
kaydedildi ve  FAR hesaplandı.

Bulgular: Elli hasta KEA grubuna dahil
edildi (% 70 erkek, ortalama yaş: 71.0 ± 7.7 ) ve 60 hasta cerrahi olmayan
grubuna dahil edildi (% 70 erkek, ortalama yaş: 63.9 ± 8.0 ). Lojistik
regresyon analizinde ileri yaş, koroner arter hastalığı ve FAR varlığı KAS gelişiminin
bağımsız bir prediktörü olarak tanımlandı. Receiver operating characteristic
(ROC) eğrisisi analizinde, KAS gelişimini tahmin etmek için FAR için % 68.0
duyarlılık ve % 65.0 özgüllük vardı (Area Under the Curve [AUC]: 0.669, 95% CI:
0.566-0.771, log rank p = 0.002).

Sonuçlar: FAR'ın KAS gelişiminin
bağımsız bir öngörücüsü olarak tanımlandığını bulduk. FAR, hastalarda karotis
aterosklerozu üzerinde potansiyel bir belirteç olabilir. Ancak, tüm
kardiyovasküler hastalıkları içeren büyük çalışmalara ihtiyaç vardır.

Keywords

Karotis arter stenozu, fibrinojen, albümin

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