Monosit/yüksek yoğunluklu lipoprotein oranının koroner arter ektaziyi öngörmedeki yararı

Year 2019, , 68 - 73, 21.03.2019

Aydın Rodi Tosu Tufan Çinar , Arda Güler Serkan Kahraman İsmail Gürbak

https://doi.org/10.18663/tjcl.478377

Cited By: 3

Abstract

Amaç: Monosit sayısının yüksek yoğunluklu lipoprotein kolesterole
oranı (MYYLKO) koroner arter hastalığı olan hastalarda yararlı bir enflamasyon
belirteci olduğu gösterilmiştir. Bu nedenle, çalışmamızdaki amacımız MYYLKO’nın
koroner arter ektazi (KAE) arasında ilişki olup olmadığını araştırmaktı.

Gereç ve yöntemler: Geriye
dönük vaka-kontrol çalışmasında, Temmuz
2013 ve Temmuz 2016 tarihleri arasında elektif koroner anjiyografi olan toplam
5500 hasta tarandı. Bu hastalardan, 150 (2,7%) hastada KAE bulundu. Kontrol
grubu yaş, cinsiyet ve vücut kitle indeksi açısından eşleşen 150 normal koroner
arter hastalarından oluştu.

Bulgular:
MYYLKO’nın ortanca değeri istatistiksel olarak KAE
hastalarında daha yüksek bulundu (p<0.05).Çoklu
değişken analizde, MYYLKO (Odds oranı:1.71, 95%Güven Aralığı:1.219-2.484, p=0.002) KAE’nin bağımsız öngörücüsü
olarak saptandı.

Sonuç:
MYYLKO’nın KAE’li hastalarda sağlıklı kişilere göre
daha yüksek olduğunu gözlemledik. Bu bulgularımız KAE ile koroner arter
hastalığının ortak bir patofizyolojik mekanizmayı işaret edebilir.

Keywords

MYYLKO, enflamasyon, koroner arter ektazisi

The usefulness of monocyte to high density lipoprotein cholesterol ratio in prediction for coronary artery ectasia

Abstract

Aim: Monocyte count to high
density lipoprotein cholesterol ratio (MHR) has been shown to be a useful inflammatory marker
in patients with coronary artery disease. Hence, the
aim of the study was to evaluate whether there is an association between
coronary artery ectasia (CAE) and MHR.

Material
and methods: In this retrospective case-control study, a total of 5500
patients who underwent an elective coronary angiography between July 2013 and
July 2016 were retrospectively screened. Of these
patients, 150 (2.7%) patients were found to have an isolated CAE. The
control group was consisted of 150 normal coronary artery
patients who matched with this group in terms of age, gender, and body mass
index.

Results: The median value of MHR was found to be a statistically higher in
patients with CAE (p<0.05). In
multivariable analyses, MHR (OR: 1.71, 95% CI: 1.219-2.484, p=0.002) was found to be an independent
predictor of CAE.

Conclusion: We observed that MHR levels were higher in CAE patients when compared
to healthy subjects. Our findings may indicate a common pathophysiological
mechanism between CAE and coronary artery disease.

Keywords

MHR, inflammation, coronary artery ectasy

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