The association of thiol/disulphide homeostasis with 6-month mortality in patients with acute st-elevation myocardial infarction

Year 2020, , 47 - 54, 26.02.2020

Mustafa Çelik , Erdoğan Sökmen , Murat Erer , Serkan Sivri , Alp Yıldırım , Yalçin Boduroğlu , Kenan Güçlü Sinan Cemgil Özbek

https://doi.org/10.18663/tjcl.563306

Cited By: 1

Abstract

Aim: Acute ST-elevation myocardial infarction (STMI) is
significant determinant of mortality and long-term mortality rates has not
changed significantly over the last two decades. Thiols are an important
anti-oxidant mechanism in the body, and excessive reactive oxygen species
oxidize the thiol into their disulphide forms. Hence, higher level of
disulphide is regarded as an indicator of oxidative stress. In the present
paper, we sought to investigate any probable relationship between
thiol/disulphide homeostasis and 6-month all-cause mortality among STMI
survivors.

Material and Methods: 238 consecutive patients with
STMI undergoing percutaneous coronary intervension were included.  Blood
samples for thiol/disulphide homeostasis were drawn on admission. Syntax I and
II scores were calculated using the cineangiographic views and relevant patient
demographics.

Results:  6-month mortality occurred in 25 patients
(mortality group), while 213 patients remained alive (non-mortality
group).  Total thiol, native thiol, disulphide, disulphide/total thiol ,
disulphide/native thiol and native thiol/total thiol were not different between
the mortality and non-mortality groups (p>0.05). Syntax I and II scores
were significantly greater in mortality group (26.11±8.06 vs 19.129.80, p=0.029
for Syntax I; 50.1314.59 vs 30.639.79, p<0.001 for Syntax II).

Conclusion: Syntax II score, glomerular filtration rate (GFR)
and white blood cell count (WBC) were found to predict 6-month mortality.

Keywords

thiol disülfide, acute myocardial infarction, mortality

Akut st-elevasyonlu miyokart infarktüsü hastalarinda 6 aylik mortalite ve thiol / disulfid ilişkisi

Abstract

Amaç: Akut ST yükselmeli miyokard infarktüsü (STMI)
mortalitenin önemli bir belirleyicisidir ve uzun dönem ölüm oranları son yirmi
yılda önemli ölçüde değişmemiştir. Tiyoller vücutta önemli bir antioksidan
mekanizmadır ve aşırı reaktif oksijen türleri tiyolü disülfür formlarına okside
eder. Bu nedenle daha yüksek seviyedeki disülfid  oksidatif stresin bir
göstergesi olarak kabul edilir. Bu yazıda STMI sağ kalanları arasında tiyol /
disülfid homeostazı ve 6 aylık tüm nedenlere bağlı ölüm arasındaki olası
ilişkiyi araştırmaya çalıştık. 

Gereç ve Yöntemler: Çalışmaya perkütan koroner
girişim uygulanan STMI' li 238  hasta dahil edildi. Giriş sırasındaki
tiyol / disülfit homeostazı için kan örnekleri alındı. Syntax  I ve II
skorları sineanjiyografik görüntüler ve ilgili hasta demografik özellikleri
kullanılarak hesaplandı. 

Bulgular:25 hastada (mortalite grubu) 6 aylık takibinde
mortalite izlendi, 213 hastada mortalite izlenmedi (mortalite dışı grup) .
Total tiyol, nativ  tiyol, disülfid, disülfid / toplam tiyol, disülfid /
nativ tiyol ve nativ tiyol / toplam tiyol, mortalite ve mortalite dışı gruplar
arasında farklı değildi (p> 0.05). Syntax I ve II skorları mortalite
grubunda anlamlı olarak daha yüksekti (26.11 ± 8.06 - 19.12 ± 9.80, Syntax I
için p = 0.029; Syntax  II için 50.13 ± 14.59 ve 30.63 ± 9.79, p
<0.001).

Sonuç: Syntax II skoru, glomerüler filtrasyon hızı (GFR)
ve beyaz kan hücre sayımının (WBC) 6 aylık mortaliteyi öngördüğü bulundu.

Keywords

thiol-disülfid, akut miyokart infatktüsü, mortalite

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