The correlation between mitral annular calcification and prognostic nutritional index

Abstract

Aim:Prior studies have established the importance of prognostic nutritional index (PNI) in patients with colorectal cancer and ST elevation myocardial infarction. However, the relation ship between the nutritional status and the mitral annular calcification (MAC) has not been investigated yet. Hence, the aim of this study was to examine the relationship between the presence of MAC and the PNI.

Material and Methods:In total, 398 patients who were admitted to our cardiology department were included in this retrospective analysis. A total of 310 patients with MAC (+) constituted the study group, while 88 subjects without MAC (-) were accepted as a control group.Clinical characteristics of the patients including age, sex, hypertension and diabetes mellitus were retrieved from hospital electronic database. The PNI was calculated using the following equation: 10×serum albumin (g/dL) + 0.005 × total lymphocyte count (per mm³).

Results:Serum albumin levels were found to be significantly lower in the MAC (+) group compared to the control group (3.76±0.57 vs. 4.12±0.31, p<0.001, respectively).  Total lymphocyte count of the MAC group was also significantly lower than the control group (1.86±0.63 vs. 2.02±0.66, p=0.05, respectively). Notably, the PNI of the MAC (+)group were significantly lower than the MAC (-) group (38.5 ± 5.8 vs. 42.2 ± 3.1; p <0.001, respectively). In correlation analysis, the PNI wasfoundto be negativelycorrelatedwiththepresence of MAC (r:-0.285; p<0.001).

Conclusion:We found that the presence of MAC is significantly associated with lower levels of the PNI.

Keywords

• mitral annular calcification,prognostic nutritional index,malnutrition

Mitral anüler kalsifikasyon ile prognostik nutrisyonel indeks arasındaki koreleasyon

Abstract

Amaç: Hastaların nütrisyonel durumu ve mitral anüler kalsifikasyon (MAK) arasında ilişki daha önce herhangi bir şekilde ortaya konulamamıştır. Daha önceki çalışmalarda prognostik nütrisyonel indeksinin (PNİ) kolorektal kanserli hastalardaoperasyon sonrası septik komplikasyonlar ve ST yükselmeli miyokart enfarktüsü gibi birçok hastalıkta prognostik öneme sahip olduğu gösterilmiştir. Bu çalışmanın amacı PNİ ile MAK varlığı arasındaki ilişkiyi ortaya koymaktır.

Gereç ve Yöntemler: Bu retrospektif çalışmaya ekokardiyografi laboratuvarına başvuran 398 hasta dahil edildi. MAK saptanan 310 hasta ile çalışma grubu,MAK saptanmayan 88 kişi ile kontrol grubu oluşturuldu. Kontrol grubuna; yaş,cinsiyet,hipertansiyon ve diyabetesmellitus varlığı gibi demografik özellikler açısından, MAK (+) grupla benzer özellikler taşıyan hastalar dahil edildi. Laboratuvar parametreleri kaydedildi ve PNİ değerleri hesaplandı.

Bulgular: Gruplar arasında ortalama yaş, hipertansiyon ve diyabet varlığı açısından fark mevcut değildi. Serum albümin düzeyleri MAK (+) grupta kontrol grubuna göre istatistiki olarak anlamlı olacak şekilde daha düşük seviyelerde saptandı (3,76±0,57; 4,12 ±0,31,p<0,001). Lenfosit sayısı MAK (+) grupta kontrol grubuna göre sınırda düşük saptandı (1,86±0,63; 2,02 ±0,66,p =0,05)Prognostik nütrisyonel indeks, mitral anulus kalsifikasyonu saptanan hasta grubunda kontrol grubuna göre anlamlı olarak düşük saptandı (38,5±5,8 ; 42,2±3.1 ,p <0,001). Prognostik nütrisyonel düzeyi mitral anulus kalsifikasyonun bulunması açısından istatiksel olarak anlamlı ve güçlü, bağımsız bir risk faktörü olarak saptandı.

Sonuç: Çalışmamız sonuç olarak MAK varlığı ile PNİ birbiriyle ilişkili bulmuştur. MAK pozitifliği ile düşük seviyedeki PNİ değeri istatistiksel olarak anlamlı bir şekilde ilişkili bulunmuştur. 

Keywords

• Mitral annüler kalsifikasyon,prognostik nutrisyonel indeks

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