Ozone application and its place in oral surgery: A review

Abstract

Ozone (O₃) is a colorless , natural , pungent gas composed of three oxygen atoms.
It is located in the strafosphere layer of the atmosphere and filters out harmful ultraviolet rays from the sun. In the fırst years after the discovery it was used for  disinfection , the studies carried out over the years have raised the use of ozone in medicine. Many studies are being carried out today for the treatment of ozone with antimicrobial, biosynthetic, analgesic, antihypoxic and immunomodulator properties. In this review, general information about ozone is given; the usage areas of ozone and its effects on wound healing are mentioned.

Keywords

• ozone,wound healing,oral surgery

Ozon uygulaması ve oral cerrahideki yeri: Derleme

Abstract

Ozon (O₃) üç oksijen atomundan oluşan  renksiz , keskin kokulu doğal bir gazdır. Atmosferin stratosfer tabakasında bulunur ve güneşten gelen zararlı ultraviyole ışınlarını süzer. Keşfinden sonraki ilk yıllarda dezenfeksiyon amacıyla kullanılırken yıllar içinde yapılan çalışmalar tıp alanında kullanımını artırmıştır. Antimikrobiyal , biyosentetik, analjezik , antihipoksik , immünmodülatör gibi özellikleri bulunan ozonun tedavi amacıyla kullanılması ile ilgili günümüzde  birçok çalışma yapılmaktadır. Bu derlemede ozon ve ozonun  kullanım alanları ile yara iyileşmesi üzerindeki etkilerinden bahsedilmiştir.

Keywords

• ozon,yara iyileşmesi,oral cerrahi

References

1. 1. Yeğin Z, Tosun G. Diş hekimliğinde ozon ve kullanım alanları. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 2013; 1: 116-22.
2. 2. Gupta G, Mansi B. Ozone therapy in periodontics. Journal of medicine and life 2012; 5: 59-67
3. 3. Bocci V. Does ozone therapy normalize the cellular redox balance?: Implications for the therapy of human immunodeficiency virus infection and several other diseases. Medical hypotheses 1996; 46:150-54.
4. 4. Korkmaz DH, Küçükkolbaşı H. Diş Hekimliğinde ozon uygulamaları. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 2013;23:125-34.
5. 5. Güzel Ö, Yıldar E, Erdikmen D. Medikal Ozon ve Veteriner Cerrahide Kullanımı. İstanbul Üniversitesi Veteriner Fakültesi Dergisi 2011; 37: 177-84.
6. 6. Özler M, Öter Ş, Korkmaz A. Ozon Gazının Tıbbi Amaçlı Kullanılması. TAF Preventive Medicine Bulletin 2009; 8: 59-64.
7. 7. Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Archives of medical research 2006; 37: 425-35.
8. 8. Nogales CG, Ferrari PH, Kantorovich EO, Lage-Marques J. Ozone therapy in medicine and dentistry. J Contemp Dent Pract 2008; 9: 75-84.

9. 9. Kazancioglu H, Kurklu E, Ezirganli S. Effects of ozone therapy on pain, swelling, and trismus following third molar surgery. International journal of oral and maxillofacial surgery 2014; 43: 644-48.
10. 10. Baysan A, Lynch E. The use of ozone in dentistry and medicine. Primary Dental Care 2005; 12: 47-52.
11. 11. Lynch E. Evidence-based caries reversal using ozone. Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry 2008; 20: 218-22.
12. 12. Seidler V, Linetskiy I, Hubalkova H, Stankova H, Smucler R, Mazanek J. Ozone and its usage in general medicine and dentistry. A review article. Prague medical report 2008; 109: 5-13.
13. 13. Li LJ, Yang YG, Zhang ZL et al. Protective effects of medical ozone combined with traditional Chinese medicine against chemically-induced hepatic injury in dogs. World journal of gastroenterology 2007;13(45):5989-94.
14. 14. Kotze M, Butow KW, Olorunju SA, Kotze HF. Ozone treatment of alveolar bone in the cape chacma baboon does not enhance healing following trauma. Journal of maxillofacial and oral surgery 2014; 13: 140-47.
15. 15. Huth KC, Jakob FM, Saugel B et al. Effect of ozone on oral cells compared with established antimicrobials. European journal of oral sciences 2006; 114: 435-40.
16. 16. Erdemci F, Gunaydin Y, Sencimen M et al. Histomorphometric evaluation of the effect of systemic and topical ozone on alveolar bone healing following tooth extraction in rats. International journal of oral and maxillofacial surgery 2014; 43: 777-83. 17. Clavo B, Pérez JL, López L et al. Ozone therapy for tumor oxygenation: a pilot study. Evidence-Based Complementary and Alternative Medicine 2004; 1: 93-98.
17. 18. Bocci V, Paulesu L. Studies on the biological effects of ozone 1. Induction of interferon gamma on human leucocytes. Haematologica 1990; 75: 510-15.
18. 19. Travagli V, Zanardi I, Valacchi G, Bocci V. Ozone and ozonated oil in skin diseases: A Review. Mediators of Inflammation 2010: 1-10
19. 20. Kim HS, Noh SU, Han YW et al. Therapeutic effects of topical application of ozone on acute cutaneous wound healing. Journal of Korean medical science 2009; 24: 368-74.
20. 21. Aktaş Ş. Diyabetik ayakta fiziksel yardımcı yöntemleri. TOTBİD Dergisi 2015; 14: 462-69 22. Zhang J, Guan M, Xie C, Luo X, Zhang Q. Increased growth factors play a role in wound healing promoted by noninvasive oxygen-ozone therapy in diabetic patients with foot ulcers. Oxid Med Cell Longev 2014: 273-5 23. Martínez-Sánchez G, Al-Dalain SM, Menéndez S et al. Therapeutic efficacy of ozone in patients with diabetic foot. European Journal of Pharmacology 2005; 523: 151-61.
21. 24. Campanati A, De Blasio S, Giuliano A et al. Topical ozonated oil versus hyaluronic gel for the treatment of partial-to full-thickness second-degree burns: A prospective, comparative, single-blind, non-randomised, controlled clinical trial. Burns 2013; 39: 1178-83.
22. 25. Lu W ,Li YH, He XF . Treatment of large lumbal disc herniation with percutaneous ozone injection via the posterior-latera route and inner magrin of the facet joint. World Journal of Radiology 2010; 2: 109-12 26. Verhein KC, Jacoby DB, Fryer AD. IL-1 receptors mediate persistent, but not acute, airway hyperreactivity to ozone in guinea pigs. American journal of respiratory cell and molecular biology 2008; 39: 730-38. 27. Marchetti D, La Monaca G. An unexpected death during oxygen-ozone therapy. The American journal of forensic medicine and pathology 2000; 21: 144-47. 28. Al-Omiri MK , Alhijawi M , AlZarae BK, AbulHassan RS, Lynch E. Ozone Treatment Of Recurrent Aphthous :A Double Blinded Study. Scientific Reports 2016; 6: 1-7.
23. 29. Burns DT. Early problems in the analysis and the determination of ozone. Fresenius' journal of analytical chemistry 1997; 357: 178-83.
24. 30. Saini R. Ozone therapy in dentistry: A strategic review. Journal of natural science, biology, and medicine 2011; 2: 151-53. 31. Stübinger S, Sader R, Filippi A. The use of ozone in dentistry and maxillofacial surgery: a review. Quintessence international 2006; 37: 353-59.
25. 32. Ebensberger U, Pohl Y, Filippi A. PCNA expression of cementoblasts and fibroblasts on the root surface after extraoral rinsing for decontamination. Dental Traumatology 2002; 18: 262-66.
26. 33. Agrillo A, Ungari C, Filiaci F, Priore P, Iannetti G. Ozone therapy in the treatment of avascular bisphosphonate-related jaw osteonecrosis. Journal of Craniofacial Surgery 2007; 18: 1071-75.
27. 34. Agrillo A, Sassano P, Rinna C, Priore P, Iannetti G. Ozone therapy in extractive surgery on patients treated with bisphosphonates. Journal of Craniofacial Surgery 2007; 18: 1068-70.
28. 35. Matsumura K, Hyon SH, Nakajima N, Tsutsumi S. Effects on gingival cells of hydroxyapatite immobilized on poly(ethylene-co-vinyl alcohol). Journal of biomedical materials research Part A 2007; 82: 288-95.
29. 36. Burdurlu Ç, Delilbaşı Ç, Deniz E, Arslan A. Mandibüler gömülü üçüncü molar cerrahisi sonrası topikal ozon ve klorheksidin uygulamasının alveolit ve yara enfeksiyonu üzerine etkilerinin araştırılması. Turkiye Klinikleri Journal of Dental Sciences 2011; 17: 17-23.
30. 37. Homutinnikova N, Durnovo E. The Effect of Ozone on the Lipid Peroxidation Processes in Case of Mandible Fractures. Nizhny Novgorod State Medical Academy, Department of Surgical Dentistry and Maxillofacial Surgery Russia 1999: 1-42.
31. 38. Cruz Guerra O, Menéndez Cepero S, Martínez Jordán ME, Vázquez C. Aplicación de la ozonoterapia en el tratamiento de la alveolitis. Revista Cubana de Estomatología 1997; 34: 21-24.
32. 39. Bayer S, Kazancioglu HO, Acar AH, Demirtas N, Kandas NO. Comparison of laser and ozone treatments on oral mucositis in an experimental model. Lasers in medical science 2017; 32: 673-77.
33. 40. Ozturk O, Tezcan AH, Adali Y et al. Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury. Acta cirurgica brasileira 2016; 31: 730-35.
34. 41. Yucesoy T, Kutuk N, Canpolat DG, Alkan A. Comparison of Ozone and Photo-Biomodulation Therapies on Mental Nerve Injury in Rats. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2017; 75: 2323-32.