Akromegali hastalarında yağlı karaciğer

Year 2020, , 33 - 38, 26.02.2020

Aynur Arslan , Emine Kartal Baykan , Nazligul Karauzum Yalcın , Mustafa Utlu , Havva Tugba Kıper Yılmaz , Alperen Akansel Caglar , Emre Deve , Emrah Dogan Ayse Carlıoglu

https://doi.org/10.18663/tjcl.604304

Abstract

Amaç: Akromegali hastalarında, diabetes mellitus, insülin
direnci ve hipertrigliseridemi gibi metabolik durumlara sıklıkla rastlanır.
Bizim amacımız, akromegali hastalarında, non alkolik yağlı karaciğer (NAFLD)
gelişmesinde etkili olan faktörleri saptamaktır.

Gereç
ve Yöntemler:
60 (33 kadın, 27 erkek) akromegali hastası ve 52 sağlıklı kişiden (27 kadın ve
25 erkek) oluşan kontrol grubu retrospektif olarak incelendi. Hastaların ve
kontrol grubunun ortalama yaşı sırasıyla 44.11 ±13.83 ve
39.12±14.99’du. Beden kitle indeksi (BKİ), karaciğer ultrasonografisi ve
laboratuvar sonuçları dosyalarındaki kayıtlardan alındı. İstatistik analizlerde
IBM SPSS Versiyon 22.0
istatistiksel paket programı (IBM
Corporation, USA) kullanıldı.

Bulgular:
Akromegali hastalarında açlık kan şekeri, trigliserid, insülin benzeri büyüme
faktörü, büyüme hormonu (GH) ve CRP seviyeleri kontrol grubuna göre anlamlı
derecede yüksek, HDL düzeyleri anlamlı derecede düşük bulundu. Grupların BKİ ve
NAFLD oranları benzerdi. Akromegali hastalarında BKİ ve GH’un NAFLD gelişmesinde
en önemli iki faktör olduğu sonucuna ulaştık. NAFLD, hastanın BKİ, kilo ve yaşı
ile anlamlı derecede pozitif, GH düzeyi ile anlamlı derecede negatif korelasyon
gösterdi.

Sonuç:
Akromegali hastalarında, NAFLD gelişmesini etkileyen faktörler BKİ ve GH’dur.

Keywords

acromegaly, non-alcoholic fatty liver disease, body-mass index

Fatty liver in patients with acromegaly

Abstract

Aim:
Patients
with acromegaly are at risk of metabolic diseases, such as diabetes mellitus,
insulin resistance and hypertriglyceridemia. We aimed to investigate what is
effective in the development of non-alcoholic fatty liver disease (NAFLD) in
patients with acromegaly.

Materials
and Methods: 60 (33 female, 27 male) patients with
acromegaly, and a healthy control group of 52 persons (27 female and 25 male)
were retrospectively studied. Mean age of the patients and the control group
were 44.11 ±13.83 and 39.12±14.99 respectively. Body mass index (BMI), liver
ultrasound and laboratory findings were taken from the records in the files.
Statistical analyzes were performed using SPSS statistical software package
version 22 (IBM Corporation, USA).

Results:
Fasting
blood sugar, triglyceride, insulin like growth factor, growth hormone(GH) and
CRP levels were significantly higher, HDL levels were significantly lower in
acromegaly group. BMI and NAFLD were similar between groups. We found that, BMI
and GH are the most important two factors in the presence of NAFLD in patients
with acromegaly. NAFLD correlates significantly positively with the patient's
BMI, weight and age; significantly negatively with the GH levels.

Conclusion:
In
people with acromegaly, BMI and GH levels are the things that affect
development of NAFLD.

Keywords

acromegaly, non-alcohololic fatty liver disease, body mass index

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