The association of platelet-to-lymphocyte ratio with in-hospital acute stent thrombosis in non-st elevated acute coronary syndromes

Abstract

Aim:Cardiovascular diseases are the leading causes of mortality in the world. Interventional methods used in the treatment of coronary artery disease have revolutionized the treatment of the disease. Balloon angioplasty and coronary stenting are two miraculous treatment methods of the disease. Acute stent thrombosis(ST) is a serious and mortal complication of stent thrombosis. Platelet-to-lymphocyte ratio (PLR), a novel inflammatory marker, has previously been shown to be associated with cardiac problems. In this study, we aimed to investigate the association of PLR with in hospital acute stent thrombosis.
Material and Methods: 1300 patients without ST elevated myocardial infarction (NSTEMI )who underwent stent implantation between January 2013 and December 2013 in our hospital were included in the study. Demographic, clinical, angiographic and laboratory parameters of all participants were recorded.
Results:In the ST+ group hypertension, diabetes mellitus rates were higher, clopidogrel loading time was shorter. The mean PLR value was significantly higher in the ST+ group as compared to ST- group (133.3 ± 75.0 vs 110.1 ± 47.0, p= 0.005). In the multivariate analyses hypertension, diabetes mellitus, shorter clopidogrel loading time and PLR was found to be independent predictors of acute stent thrombosis.
Conclusion:Our results demonstrated that PLR is an independent predictor of acute stent thrombosis in Non-ST elevated acute coronary syndrome patients.

Keywords

• acute stent thrombosis,platelet-to-lymphocyte ratio,coronary artery disease,inflammation

Non-ST eleve akut koroner sendromda platelet/lenfosit oranının akut stent trombozunu öngörmedeki rolü

Abstract

Amaç: Kardiyovaskuler hastalıklar dünyada önde gelen mortalite nedenidir. Akut stent trombozu (ST) stent implantasyonunun çok ciddi ve mortal bir komplikasyonudur. Yeni bir enflamatuar belirteç olan platelet/lenfosit oranının (PLR) daha önce kalp problemleriyle ilişkili olduğu gösterilmiştir. Bu çalışmada, ST- segment yükselmesiz akut koroner sendromlarda (ST- segment yükselmesiz myokard enfarktüsü ve kararsız angina) PLR ile akut stent trombozunun (ST) ilişkisini araştırmayı amaçladık.
Gereç ve Yöntemler: Çalışmamıza Ocak 2013- Aralık 2013 tarihleri arasında stent implantasyonu yapılan, ST- segment yükselmesiz akut koroner sendrom hastası 1300 hasta dahil edildi. Tüm hastaların demografik, klinik, anjiyografik ve laboratuvar parametreleri kaydedildi.
Bulgular: ST (+) grupta hipertansiyon, diabetes mellitus oranları daha yüksekti, klopidogrel yükleme süresi daha kısaydı. Ortalama PLR değeri ST (+) grupta ST (-) gruba göre anlamlı olarak daha yüksekti (133.3 ± 75.0'a karşı 110.1 ± 47.0, p = 0.005). Çok değişkenli analizlerde hipertansiyon, diabetes mellitus, kısa klopidogrel yükleme süresi ve PLR'nin akut stent trombozunun bağımsız öngördürücüleri olduğu bulundu.
Sonuç: Bulgularımız PLR' nin, ST- segment yükselmesiz akut koroner sendrom hastalarında akut stent trombozunun bağımsız bir öngördürücüsü olduğunu göstermiştir.

Keywords

• akut stent trombozu,platelet/lenfosit oranı,koroner arter hastalığı,inflamasyon

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