Bruselloz hastalarında serum YKL-40 düzeylerinin belirlenmesi

Year 2019, Volume: 10 Issue: 3, 335 - 339, 30.09.2019

Fikriye Milletli Sezgin , Rukiye Nar

https://doi.org/10.18663/tjcl.472868

Abstract

Amaç: Bruselloz tanılı hastalarda serum
YKL-40 düzeylerini belirlemek.

Gereç ve Yöntemler: Bu çalışmaya serum
aglütinasyon testi pozitif 40 Bruselloz hastası ve 41 sağlıklı kontrol grubu dahil
edilmiştir. İki grup arasında serum YKL-40, hematolojik parametreler ve C
reaktif protein (CRP) değerleri karşılaştırılmıştır.

Bulgular: Bruselloz hasta grubunda, YKL-40 değeri 15.0 ± 8.8 ng/mL, CRP 0.2 ± 0.1 mg/dL,
Nötrofil/ Lenfosit oranı (NLR) 1.5 ± 1.0 ve Platelet/Lenfosit oranı (PLR) 109.3
± 46.4 idi. Kontrol grubunda, YKL-40 değeri 12.7 ± 6.1ng/mL, CRP 1.48 ±
2.1mg/dL, Nötrofil/ Lenfosit oranı (NLR) 2.1 ± 0.7 ve Platelet/Lenfosit oranı
(PLR) 147.8 ± 59.0 idi.

Sonuç: YKL-40 düzeylerinde hasta ve
kontrol grubu arasında anlamlı bir fark bulunmamıştır. Hasta grubunda kontrol
grubuna göre CRP anlamlı olarak yüksek, bunun yanında YKL-40 ile CRP, PLT, PLR,
NLR ve yaş arasında pozitif korelasyon saptanmıştır. Ancak YKL-40’ ın
enfeksiyon hastalıklarında rolünün daha iyi anlaşılabilmesi için ileri
çalışmalara ihtiyaç vardır.

Keywords

Bruselloz , YKL-40 , infeksiyon

Determination of serum YKL-40 levels in patients with brucellosis

Abstract

Aim:
To determine serum YKL-40 levels in patients diagnosed with
brucellosis.

Material
and Methods: This study included 40 Brucellosis patients with
positive serum agglutination tests and 41 healthy control subjects.
The two groups were compared with regard to their serum YKL-40,
hematological parameters, and C-reactive protein (CRP) values.

Results:
The brucellosis patient group presented YKL-40 values of 15.0 ± 8.8
ng/mL, CRP values of 0.2 ± 0.1 mg/dL, a Neutrophil/Lymphocyte ratio
(NLR) of 1.5 ± 1.0, and a Platelet/Lymphocyte ratio (PLR) of 109.3 ±
46.4. The control group presented YKL-40 values of 12.7 ± 6.1ng/mL,
CRP values of 1.48 ± 2.1mg/dL, a Neutrophil/Lymphocyte ratio (NLR)
of 2.1 ± 0.7, and a Platelet/Lymphocyte ratio (PLR) of 147.8 ±
59.0.

Conclusion:
No significant differences were determined between the YKL-40 levels
of the patient and control groups. The patient group manifested
significantly higher levels of CRP compared to the control group, and
YKL-40 was determined to be positively correlated with CRP, PLT, PLR,
NLR and age. However, further studies are needed for the role of
YKL-40 in infectious diseases to be understood more clearly.

Keywords

brucellosis , YKL-40 , diagnostic value

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