Analysis of Protein C Inhibitor/ SERPINA5

Year 2020, 2020 Özel Sayı, 75 - 79, 26.02.2020

Didem Özkan , Nejat Akar

https://doi.org/10.18663/tjcl.645392

Cited By: 2

Abstract

Protein C inhibitor is a non-specific serine protease inhibitor with extensive protease reactivity. Protein C inhibitor (SERPINA5, plasminogen activator inhibitor-3/PAI-3) is a secreted, extracellular clade A serpin. SERPINA5/PCI has originally been described as an inhibitor of activated protein C and independently as an inhibitor of the plasminogen activator urokinase. SERPINA5 binds glycosaminoglycans, phospholipids, and retinoic acid. Glycosaminoglycans and certain phospholipids can modulate its inhibitory activity and specificity.  PCI plays role at thrombosis and fibrinolysis, regulation of fertilization, tissue regeneration, vascular permeability, tumor development, invasion, metastasis and angiogenesis. In this review; aimed  to provide information about the functions of PCI and to provide guidance for studies.

Keywords

Protein C Inhibitor, SERPINA5

Protein C İnhibitörü/SERPİNA5 analizi

Abstract

Protein C inhibitörü (PCI), serin
proteaz ailesinden (SERPINA5) α1 proteaz inhibitiör prototipinde bir plazma
glikoproteinidir. İlk olarak insan plazmasında aktive protein C inhibitörü
olarak daha sonra ise koagülasyon ve fibrinolizisin inhibitörü olarak
tanımlanmıştır. PCI, idrardan sekrete olur ve ürokinaz tipi plazminojen
aktivatörü (uPA) ile kompleks oluşturur.  Bu nedenle plazminojen aktivatör inhibitörü 3
(PAI-3) olarak da bilinir. PCI’nın tromboz ve fibrinoliziste, fertilizasyonun
düzenlenmesinde, doku rejenerasyonunda, vasküler permeabilitede, tümör gelişimi,
invazyon, metastaz ve anjiyogenezin düzenlenmesinde rol oynadığı bilinmektedir Bu derlemede; PCI'ın işlevleri hakkında bilgi vermek ve ileride yapılacak çalışmalar
için rehberlik sağlamak amaçlanmıştır.

Keywords

Protein C, SERPINA5

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