Yaşlılarda diyet alışkanlıkları ile mitral anüler kalsifikasyon arasında ki ilişki: Çölleşmenin etkisi

Year 2020, Volume: 11 Issue: 2, 66 - 71, 21.03.2020

Candan Mansuroglu

https://doi.org/10.18663/tjcl.671922

Abstract

Amaç: Bu çalışma önceleri yaşlanma ile alakalı bir olay olarak düşünülen mitral anüler kalsifikasyon oluşumunda diyetin olası rolünü araştırmak için planlandı.

Gereç ve Yöntemler:Mitral anüler kalsifikasyonu olan 85 adet ve olmayan 91 adet hasta bu çalışmaya dahil edildi.Tüm hastalara gönüllülük esasına bağlı olarak onaylı ve kapsamlı diyet hikayesiniiçeren, kendi kendilerine cevaplayabildikleri 36 parametrelik anketuygulandı. Olası risk faktörlerinin tek yönlü ve çok yönlü analizleri yapıldı.

Bulgular: Mitral anüler kalsifikasyonKırıkkale, Kırsehir, Yozgat, Aksaray, Nevsehir ve Mardin şehirlerinde yaşayan hastalarda belirgin ve bağımsız olarak fazla bulundu( OR= 1, 65, % 95 CI= 1, 25 - 2, 89; p< 0, 001).Bu şehirler İç Anadolu Bölgesinin en fazla kurak, tuzlu ve kalsifik topraklarına sahip şehirleridir ve çölleşme etkisi ile daha tuzlu ve kalsifik olmaktadır. Mitral anüler kalsifikasyon Ordu ve Sinop şehirlerinde yaşayanlarda anlamlı olarak düşüktü( OR= 1, 78, % 95 CI= 1, 02 - 2, 89; p< 0, 01). Bu şehirler Karadeniz Bölgesinin en fazla nem içeren topraklarının bulunduğu şehirlerdir.Mitral anüler kalsifikasyon yaşlıda( OR= 2, 55, % 95 CI= 1, 05 - 3, 93; p=0, 05), kadınlarda(OR= 1, 35,  % 95 CI= 1, 05 - 1, 89; p= 0, 04), diyabeti olanlarda( OR= 1, 85, %95 CI= 1, 15 - 3, 21; p< 0, 001) ve statin kullananlarda( OR=3, 01, % 95 CI= 1, 59 - 5, 72; p= 0, 01) belirgin olarak yüksek bulundu. Mitral anüler kalsifikasyonu olan ve olmayan hastaların beslenmelerinde anlamlı bir fark bulunmadı(p= 0, 23).

Sonuç:Çalışma sonuçları, mitral anüler kalsifikasyon ile beslenme arasında bir bağlantıgösteremedi ancakliteratürde ilk kez mitral anüler kalsifikasyon ile Anadolu Bölgesi’ nin kurak toprak yapısıarasında bir ilişki olabileceğini düşündürdü.

Keywords

Diyet, İklim, Klasifikasyon, mitral anulus, yaşlanma

Supporting Institution

yok

Project Number

yok

The relation between mitral annular calcification and dietary habits: Impact of desertification

Abstract

 Aim: This study is planned to find out the potencial role of diet on the formation of mitral annular calcification initially tought to be age-related process.

Material and Methods: A total of 85 patients with mitral annular calcification and 91 patients with no- mitral annular calcification were enrolled in this cross- sectional study. A validated, self-administered, comprehensive 36 parameters- diet history questionnaire was applied to all patients on a voluntary basis. Univariate and multivariate analysis were done with possible risk factors.

Results: Mitral annular calcification was found significantly and independently higher in patients living in Kırıkkale, Kirsehir, Yozgat, Aksaray, Nevsehir and Mardin( OR= 1. 65, 95% CI= 1. 25 – 2. 89; p< 0, 001). These Central Anatolia cities’ have soils with higher calcium, and higher salt, and lower humidity and soils have becoming more saltier and more calcified with desertification effects. Mitral annular calcification was found significantly and independently lower in patients living in Ordu and Sinop( 0R= 1. 78, 95% CI= 1. 02 – 2. 89; p< 0. 01). These Black Sea Region cities’ have the most humid soil types. Mitral annular calcifications were found significantly higher in aged( OR= 2. 55, 95%  CI= 1. 05 – 3. 93; p=0. 05),in women( OR= 1. 35, 95% CI= 1. 05 – 1. 89; p=0. 04), in diabetes( OR= 1. 85, 95% CI= 1.15 – 3. 21; p< 0. 001 )and in statin usage( OR=3. 01, 95% CI= 1. 59 – 5. 72; p= 0. 01). We didn’ t find any correlation between foods and with mitral annular calcification( p=  0. 23).

Conclusion: Our study couldn’ t demonstrate any association between mitral annular calcification and with a special food group but made to think for the first time in the literature a possible correlation between mitral annular calcification and with low humidity Cental Anatolia soil types

Keywords

diet, climate, calcification, mitral annulus, ageing

Project Number

yok

References

• 1. Zoghi M. Cardiovascular functions in the elderly. Turkish Journal of Geriatrics 2010; 2: 1-4.
• 2. Fox CS, Vasan RS, Parise H et al. Mitral annular calcification predicts cardiovascular morbidity and mortalİty. the Framingham Heart Study. Circulation 2003; 107: 1492– 96.
• 3. Fox CS, Parise H, Vasan RS et al. Mitral annular calcification is a predictor for incident atrial fibrillation. Atherosclerosis 2004; 173: 291–94.
• 4. Atar S, Jeon DS, Luo H, Siegel RJ.Mitral annular calcification: a marker of severe coronary artery disease in patients under 65 years old. Heart 2003; 89: 161–64.
• 5. Kanjanauthai S, Nasir K,Katz R et al. Relationship of mitral annular calcification to cardiovascular risk factors: the Multi- Ethnic Study of Atherosclerosis( MESA). Atherosclerosis 2010; 213: 558- 62.
• 6.Foley PW, Hamaad A, El- Gendi H et al. Incidental cardiac findings on computed tomography imaging of the thorax. BMC Res Notes 2010; 3: 326.
• 7. Johnson RC, Leopold JA, Loscalzo J. Vascular calcification: pathobiological mechanisms and clinical implications. Circ Res 2006; 99: 1044–59.
• 8.Hruby A, O’Dennel CJ, Jacques PF, Meigs JB, Hoffman U, McKeown NM. Magnesium intake is inversely associated with coronary artery calcification: The Framingham Heart Study. JACC Cardiovasc. Imaging 2014; 7: 59- 69.
• 9. Shatenstein B, and Payette H. Evaluation of the Relative Validity of the Short Diet Questionnaire for Assessing Usual Consumption Frequencies of Selected Nutrients and Foods Nutrients 2015; 7: 6362–74.
• 10. Erlat F, Turkes M. Analysis of observed variability and trends in numbers of frost days in Turkey for the period 1950- 2010. Int J Climate 2012; 32: 12.
• 11. Barasch E, Gottdiener JS, Larsen EKM et al.Clinical significance of calcification of the fibrous skeleton of the heart and aortosclerosis in community dwelling elderly. The cardiovascular Health Study (CHS). Am Heart J 2006; 151: 39–47.
• 12. Rudolf MI, Rader DJ, Reilly MP et al. Relationship of estimated GFR and coronary artery calcification in the CRIC( Chronic Renal Insufficiency Cohort) Study. Am J Kidney Dis 2011; 58: 519-26.
• 13.Schurgers IJ, Sponik HM, South BA et al. Regression of warfarin- induced medial elastocalsinosis by high intake of vitamin K in rats. Blood 2007; 109: 2823-31.
• 14. Adler Y, Fink N, Spector D et al. Mitral annulus calcification- a window to diffuse atherosclerosis of the vascular system. Atherosclerosis 2001; 155: 1-8.
• 15. Helske S, Syvaranta S, Kupari M, et al. Possible role for mast cell- derived cathepsin G in the adverse remodelling of stenotic aortic valves. Eur Heart J 2006; 27: 1495-1504.
• 16.Kohsaka S, Jin Z, Rundek T et al. Impact of mitral annular calcification on cardiovascular morbidity and mortality: the Northern Manhattan Study. JACC Cardiovasc Imaging 2008; 1: 617- 23.
• 17. PotparaTS, Vasiljevic ZM, Vujisic- Tesic BD et al. Mitral annular calcification predicts cardiovascular morbidity and mortality in middle- aged patients with atrial fibrillation: The Belgrade Atrial Fibrillation Study. Chest 2011; 140: 902-10.
• 18. Haklı G, Cakıroglu FP. An evaluation of nutritional habits and blood findings of elderly male and female cardiac patients.Turkish Journal of Geriatrics 2011; 14: 54-62.
• 19. Tanık V, Erken PH. Mitral anüler kalsifikasyon ile prognostik nutrisyonel indeks arasındaki koreleasyon. Turkish Journal of Clinics and Laboratory 2019; 10: 452-58.
• 20.Ramsden CE, Domenichiello AF. PURE study challenges the definition of a healthy diet: key questions remain. Lancet 2017; 398: 2018- 19.
• 21. International Govermental Panel on Cilmate Change( IPCC) 2007: The Physical Science Basis. In: Solmon S, Qin d, Manning M, et al( eds). Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change Cambridge University Press: Cambridge, United Kingdom and New York, USA. First published 2007, pp 1-49.