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Bölgemizde tiroid kanseri sıklığında ve bazı alt tiplerin dağılımında gözlenen değişimler; 4917 tiroidektominin retrospektif analizi

Year 2020, Volume: 11 Issue: 5, 372 - 377, 30.12.2020
https://doi.org/10.18663/tjcl.751922

Abstract

Amaç: Bu tanımlayıcı çalışmanın amacı, bölgemizdeki tiroid kanseri (TK) sıklığını belirlemek ve histopatolojik tiplerin değişen oranlarını, tiroid tümörlerinin yaş ve cinsiyet dağılımını değerlendirmektir.
Gereç ve Yöntemler: Mayıs 2010 ile Mayıs 2019 tarihlerinde arasında farklı endikasyonlarla tiroidektomi uygulanan 4917 hasta bu retrospektif çalışmaya dahil edildi. Hastaların yaşı, cinsiyeti, seçilen cerrahi yöntem ve postoperatif nihai patoloji sonuçları kaydedildi. Tüm veriler istatistiksel analizler kullanılarak değerlendirildi.
Bulgular: Dörtbindokuzyüzonyedi hastanın 922'si erkek (% 18,8) ve 3995'i kadın (% 81,2) idi. Yaş ortalaması 48,3 ± 12,3 (17-84) idi. Tüm vakaların % 27,1'i (1335) malign,% 2,6'sı (125) malignite potansiyeli belirsiz iyi diferansiye tümördü. Malign tiroid tümörü tanısı konan 1335 olgunun yaş ortalaması 44,7 ± 11,6 yıl, kadın / erkek oranı 4,3 idi. Bunların % 94,9'unda papiller tiroid karsinomu (PTK), % 1,72'sinde foliküler tiroid karsinomu (FTK), % 2,32'sinde medüller tiroid karsinomu (MTK), ve % 0,45'inde anaplastik tiroid karsinomu vardı. PTK olan olguların% 62,66'sında mikrokarsinom vardı.
Sonuç: Bölgemizde özellikle genç ve kadın popülasyonda papiller tiroid mikrokarsinom (PTMK) sıklığı artmakta, FTK sıklığı önemli ölçüde azalmaktadır ve MTK, papiller kanserlerden sonra ikinci en sık görülen TK tipidir. Tüm TK’lerinde, % 59,47 PTMK payı (çoğunlukla tesadüfen saptanmıştır, % 83,7), zaman içinde patologların daha fazla doku bloğunu incelemesi ve histolojik örnekleme yapmasının bir sonucu gibi görünmektedir.

References

  • 1. Thun MJ, Linet MS, Cerhan JR, Haiman CA, Schottenfeld D (Eds). Cancer Epidemiology and Prevention. 4th ed. New York: Oxford University Press; 2018.p.839-860.
  • 2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019; 69: 7-34.
  • 3. Vaccarella S, Franceschi S, Bray F, Wild CP, Plummer M, Dal Maso L. Worldwide thyroid-cancer epidemic? The increasing impact of overdiagnosis. N Engl J Med 2016; 375: 614-7.
  • 4. Howlader N, Noone AM, Krapcho M et al. SEER Cancer Statistics Review, 1975–2013. Bethesda: National Cancer Institute, 2016; http://seer.cancer.gov/csr/1975_2013 (accessed May 12, 2016).
  • 5. Cabanillas ME, McFadden DG, Durante C. Thyroid cancer. Lancet 2016; 388: 2783-95.
  • 6. Widder S, Pasieka JL. Primary thyroid lymphomas. Curr Treat Options Oncol 2004; 5: 307-13.
  • 7. Gültekin M, Boztaş G. Türkiye kanser istatistikleri. SB, Türkiye Halk Sağlığı Kurumu 2014; 43.
  • 8. Özgüven BY, Yener Ş, Başak T, Polat N, Kabukçuoğlu F. Tiroid operasyon materyali histopatolojik tanılarının retrospektif olarak değerlendirilmesi. ŞEH Tıp Bülteni 2008; 42: 5-9.
  • 9. Rego-Iraeta A, Perez-Mendez LF, Mantinan B, Garcia- Mayor RV. Time trends for thyroid cancer in Northwestern Spain: true rise in the incidence of micro and larger forms of papillary thyroid carcinoma. Thyroid 2009; 19: 333–40.
  • 10. Wiltshire JJ, Drake TM, Uttley L, Balasubramanian SP. Systematic review of trends in the incidence rates of thyroid cancer. Thyroid 2016; 26: 1541-52.
  • 11. Chan JKC. Tumours of the Thyroid and Parathyroid Glands. In: Fletcher CDM editors. Diagnostic Histopathology of Tumours. 4th ed. Philadelphia, USA: Saunders, an imprint of Elsevier Inc; 2013;1177-1293.
  • 12. Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973-2002. Jama 2006; 295: 2164-7.
  • 13. Horn-Ross PL, Lichtensztajn DY, Clarke CA et al. Continued rapid increase in thyroid cancer incidence in California: trends by patient, tumour, and neighborhood characteristics. Cancer Epidemiol Biomarkers Prev 2014; 23: 1067-79.
  • 14. McHenry CR, Phitayakorn R. Follicular adenoma and carcinoma of the thyroid gland. Oncologist 2011; 16: 585-93.
  • 15. Cetin H, Kisioglu AN, Gursoy A, Bilaloglu E, Ayata A. Iodine deficiency and goiter prevalence in Turkey after mandatory iodization. J Endocrinol Invest 2006; 29: 714-8.
  • 16. Netea‐Maier RT, Aben KK, Casparie MK et al. Trends in incidence and mortality of thyroid carcinoma in The Netherlands between 1989 and 2003: Correlation with thyroid fine‐needle aspiration cytology and thyroid surgery. Int J Cancer 2008; 123: 1681-4.
  • 17. Erten R, Bayram İ, Demir F, Aras İ, Keskin S. Van İli ve Çevresinde Tiroid Tümörlerinin Histopatolojik Dağılımı: 733 Olgunun Retrospektif Analizi. Van Tıp Derg 2019; 26: 370-6.

Changes in the frequency of thyroid cancer and distribution of some subtypes in our region; Retrospective analysis of 4917 thyroidectomies

Year 2020, Volume: 11 Issue: 5, 372 - 377, 30.12.2020
https://doi.org/10.18663/tjcl.751922

Abstract

Aim: The aim of this descriptive study is to determine the frequency of thyroid cancer (TC) and evaluate the changing rates of histopathological types, age and sex distribution of thyroid tumours in our region.
Material and Methods: A total of 4917 patients who underwent thyroidectomy for different indications between May 2010 and May 2019 were included in this retrospective study. Patients’ age, sex, selected surgical method and postoperative final pathology results were recorded. All data were evaluated using statistical analyses.
Results: Of the 4917 patients, 922 were male (18.8%) and 3995 were female (81.2%). The mean age was 48.3 ± 12.3 (17-84) years. Among all cases 27.1% (1335) of them were malignant and 2.6 % (125) of them were well-differentiated tumours of uncertain malignant potential. The 1335 cases diagnosed with a malignant thyroid tumour had a mean age of 44.7±11.6 years and a female-to-male ratio of 4,3. Of these, 94.9% of them had papillary thyroid carcinoma (PTC), 1.72% had follicular thyroid carcinoma (FTC), 2.32% had medullary thyroid carcinoma (MTC), and 0.45% had anaplastic thyroid carcinoma. Of the cases with PTC, 62.66% of them had microcarcinoma.
Conclusion: Papillary thyroid microcarcinoma (PTMC) frequency increases especially in the younger and female population in our region, FTC frequency decreases significantly and MTC is the second most common type of TCs after papillary cancers. In all TCs, the 59.47% PTMC share (mostly detected incidentally, 83.7%) appears to be the result of pathologists examining more tissue blocks and histological sampling over time.

References

  • 1. Thun MJ, Linet MS, Cerhan JR, Haiman CA, Schottenfeld D (Eds). Cancer Epidemiology and Prevention. 4th ed. New York: Oxford University Press; 2018.p.839-860.
  • 2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019; 69: 7-34.
  • 3. Vaccarella S, Franceschi S, Bray F, Wild CP, Plummer M, Dal Maso L. Worldwide thyroid-cancer epidemic? The increasing impact of overdiagnosis. N Engl J Med 2016; 375: 614-7.
  • 4. Howlader N, Noone AM, Krapcho M et al. SEER Cancer Statistics Review, 1975–2013. Bethesda: National Cancer Institute, 2016; http://seer.cancer.gov/csr/1975_2013 (accessed May 12, 2016).
  • 5. Cabanillas ME, McFadden DG, Durante C. Thyroid cancer. Lancet 2016; 388: 2783-95.
  • 6. Widder S, Pasieka JL. Primary thyroid lymphomas. Curr Treat Options Oncol 2004; 5: 307-13.
  • 7. Gültekin M, Boztaş G. Türkiye kanser istatistikleri. SB, Türkiye Halk Sağlığı Kurumu 2014; 43.
  • 8. Özgüven BY, Yener Ş, Başak T, Polat N, Kabukçuoğlu F. Tiroid operasyon materyali histopatolojik tanılarının retrospektif olarak değerlendirilmesi. ŞEH Tıp Bülteni 2008; 42: 5-9.
  • 9. Rego-Iraeta A, Perez-Mendez LF, Mantinan B, Garcia- Mayor RV. Time trends for thyroid cancer in Northwestern Spain: true rise in the incidence of micro and larger forms of papillary thyroid carcinoma. Thyroid 2009; 19: 333–40.
  • 10. Wiltshire JJ, Drake TM, Uttley L, Balasubramanian SP. Systematic review of trends in the incidence rates of thyroid cancer. Thyroid 2016; 26: 1541-52.
  • 11. Chan JKC. Tumours of the Thyroid and Parathyroid Glands. In: Fletcher CDM editors. Diagnostic Histopathology of Tumours. 4th ed. Philadelphia, USA: Saunders, an imprint of Elsevier Inc; 2013;1177-1293.
  • 12. Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973-2002. Jama 2006; 295: 2164-7.
  • 13. Horn-Ross PL, Lichtensztajn DY, Clarke CA et al. Continued rapid increase in thyroid cancer incidence in California: trends by patient, tumour, and neighborhood characteristics. Cancer Epidemiol Biomarkers Prev 2014; 23: 1067-79.
  • 14. McHenry CR, Phitayakorn R. Follicular adenoma and carcinoma of the thyroid gland. Oncologist 2011; 16: 585-93.
  • 15. Cetin H, Kisioglu AN, Gursoy A, Bilaloglu E, Ayata A. Iodine deficiency and goiter prevalence in Turkey after mandatory iodization. J Endocrinol Invest 2006; 29: 714-8.
  • 16. Netea‐Maier RT, Aben KK, Casparie MK et al. Trends in incidence and mortality of thyroid carcinoma in The Netherlands between 1989 and 2003: Correlation with thyroid fine‐needle aspiration cytology and thyroid surgery. Int J Cancer 2008; 123: 1681-4.
  • 17. Erten R, Bayram İ, Demir F, Aras İ, Keskin S. Van İli ve Çevresinde Tiroid Tümörlerinin Histopatolojik Dağılımı: 733 Olgunun Retrospektif Analizi. Van Tıp Derg 2019; 26: 370-6.
There are 17 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Orıgınal Artıcle
Authors

Hakan Ataş 0000-0003-4144-417X

Buket Altun Özdemir 0000-0002-1043-8108

Bülent Çomçalı 0000-0002-2111-1477

Ebru Menekşe 0000-0003-2867-6128

Barış Saylam 0000-0001-9080-4974

Yunus Nadi Yüksek

Publication Date December 30, 2020
Published in Issue Year 2020 Volume: 11 Issue: 5

Cite

APA Ataş, H., Altun Özdemir, B., Çomçalı, B., Menekşe, E., et al. (2020). Changes in the frequency of thyroid cancer and distribution of some subtypes in our region; Retrospective analysis of 4917 thyroidectomies. Turkish Journal of Clinics and Laboratory, 11(5), 372-377. https://doi.org/10.18663/tjcl.751922
AMA Ataş H, Altun Özdemir B, Çomçalı B, Menekşe E, Saylam B, Yüksek YN. Changes in the frequency of thyroid cancer and distribution of some subtypes in our region; Retrospective analysis of 4917 thyroidectomies. TJCL. December 2020;11(5):372-377. doi:10.18663/tjcl.751922
Chicago Ataş, Hakan, Buket Altun Özdemir, Bülent Çomçalı, Ebru Menekşe, Barış Saylam, and Yunus Nadi Yüksek. “Changes in the Frequency of Thyroid Cancer and Distribution of Some Subtypes in Our Region; Retrospective Analysis of 4917 Thyroidectomies”. Turkish Journal of Clinics and Laboratory 11, no. 5 (December 2020): 372-77. https://doi.org/10.18663/tjcl.751922.
EndNote Ataş H, Altun Özdemir B, Çomçalı B, Menekşe E, Saylam B, Yüksek YN (December 1, 2020) Changes in the frequency of thyroid cancer and distribution of some subtypes in our region; Retrospective analysis of 4917 thyroidectomies. Turkish Journal of Clinics and Laboratory 11 5 372–377.
IEEE H. Ataş, B. Altun Özdemir, B. Çomçalı, E. Menekşe, B. Saylam, and Y. N. Yüksek, “Changes in the frequency of thyroid cancer and distribution of some subtypes in our region; Retrospective analysis of 4917 thyroidectomies”, TJCL, vol. 11, no. 5, pp. 372–377, 2020, doi: 10.18663/tjcl.751922.
ISNAD Ataş, Hakan et al. “Changes in the Frequency of Thyroid Cancer and Distribution of Some Subtypes in Our Region; Retrospective Analysis of 4917 Thyroidectomies”. Turkish Journal of Clinics and Laboratory 11/5 (December 2020), 372-377. https://doi.org/10.18663/tjcl.751922.
JAMA Ataş H, Altun Özdemir B, Çomçalı B, Menekşe E, Saylam B, Yüksek YN. Changes in the frequency of thyroid cancer and distribution of some subtypes in our region; Retrospective analysis of 4917 thyroidectomies. TJCL. 2020;11:372–377.
MLA Ataş, Hakan et al. “Changes in the Frequency of Thyroid Cancer and Distribution of Some Subtypes in Our Region; Retrospective Analysis of 4917 Thyroidectomies”. Turkish Journal of Clinics and Laboratory, vol. 11, no. 5, 2020, pp. 372-7, doi:10.18663/tjcl.751922.
Vancouver Ataş H, Altun Özdemir B, Çomçalı B, Menekşe E, Saylam B, Yüksek YN. Changes in the frequency of thyroid cancer and distribution of some subtypes in our region; Retrospective analysis of 4917 thyroidectomies. TJCL. 2020;11(5):372-7.


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