İlk tanı akut koroner sendrom ile başvuran hastalarda koroner arter çaplarının prediyabet ve diyabet ile ilişkisinin incelenmesi

Year 2022, Volume: 13 Issue: 2, 242 - 252, 30.06.2022

Yasin Özen , Özcan Özeke , Mustafa Bilal Özbay , Burak Açar , Mustafa Karakurt , Mevlüt Serdar Kuyumcu , Kadriye Gayretli Yayla , Çağrı Yayla , Ahmet Ertem , Dursun Aras

https://doi.org/10.18663/tjcl.1113964

Abstract

Amaç: Diyabetik hastalarda daha yaygın ve şiddetli koroner ateroskleroz vardır ve koroner arter çapları (KAÇ) yaygın
olarak etkilenir, ancak bu durum prediyabetiklerde değerlendirilmemiştir. Bu çalışma, akut koroner sendromlu hastalarda
prediyabetin KAÇ' ları üzerindeki etkilerini araştırdı.
Gereç ve Yöntemler: Bu çalışmaya dahil edilen 266 hasta "normal", "prediyabetik" ve "diyabetik" olmak üzere üç gruba ayrıldı.
Hastaların KAÇ' ları kantitatif koroner anjiyografi tekniği ile hesaplandı. Koroner segmentler belirlenen bölgelerden ölçüldü.
Bulgular: Normal gruptan farklı olarak hem prediyabetin hem de diyabetin proksimal RCA dışında damarlar üzerinde
benzer etkileri olduğunu bulduk. Ayrıca LMCA çapının en çok etkilenen koroner segment olduğunu ve proksimal LAD
çapının en çok etkilenen ikinci segment olduğunu bulduk (her ikisi için p<0,001). Total KAÇ' ları incelendiğinde distal
koroner arter segmentlerinin proximal koronerlere göre daha fazla etkilendiği görüldü (p<0,001).
Sonuç: Bu çalışma, prediyabetik hastaların koroner arter çaplarının diyabet hastalarına benzer şekilde etkilendiğini ve distal
koroner arterlerdeki daralmanın proksimal damarlara göre daha fazla etkilendiğini göstermiştir. Prediyabetin erken tanı ve
tedavisinin, perkütan veya cerrahi revaskülarizasyon için daha uygun bir koroner lezyon sağlamak açısından önemlidir.

Keywords

koroner arter çapları, HbA1c, prediyabet, akut koroner sendrom

Investigation of the relationship of coronary artery diameters with prediabetes and diabetes in patients with first diagnosis acute coronary syndrome

Abstract

Aim: Diabetic patients have a more severe and widespread coronary atherosclerosis, and their coronary artery diameters
(CADs) are widely affected, but this has not been evaluated in prediabetics. This study investigated the effects of
prediabetes on CADs in patients with acute coronary syndrome.
Material and Methods: Two hundred and sixty-six patients included in this study were divided into three groups as
"normal", "prediabetic" and "diabetic". Patients' CADs were calculated via the quantitative coronary angiography technique.
Coronary segments were measured from the designated regions.
Results: We found that both prediabetes and diabetes had similar adverse effects on vessels except the proximal RCA,
unlike the normal group. We also found that the diameter of the LMCA was the most affected coronary segment, and the
diameter of proximal LAD was second segment as affected mostly (p <0.001 for both). When total CADs were analyzed, it
was seen that distal coronary artery segments were more affected than proximal (p <0.001).
Conclusion: This study showed that coronary artery diameters of prediabetic patients were affected similarly to patients
with diabetes, and the narrowing of the distal coronary arteries was more affected than the proximal vessels. Early
diagnosis and treatment of prediabetes is important to provide a more suitable coronary lesion for percutaneous or
surgical revascularization

Keywords

Coronary Artery Diameter, Prediabetes, Acute Coronary Syndrome, HbA1c

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