COVİD 19'DA ÖNE ÇIKAN BİYOKİMYASAL PARAMETRELERİN VE D VİTAMİNİNİN DEĞERLENDİRİLMESİ

Year 2022, Volume: 13 Issue: 4, 444 - 450, 30.12.2022

Elif Menekşe , Muhammed Emin Düz , Aydın Balcı , Mustafa Durmaz

https://doi.org/10.18663/tjcl.899895

Abstract

Amaç: Bu çalışmada hastalığın seyrini tahmin etmek ve yoğun bakım ünitesine yatırılacak hastaları önceden belirlemek için potansiyel koagülasyon ve inflamasyon biyobelirteçlerini ve son dönemde sıkça vurgulanan D vitaminini değerlendirmeyi amaçladık.
Gereç ve Yöntemler: Bu retrospektif vaka-kontrol çalışması, Mart 2020'den Haziran 2020'ye kadar Amasya Sabuncuoğlu Şerefeddin Eğitim ve Araştırma Hastanesi'nde COVİD-19 tanısı alıp tedavi edilen 121 hasta üzerinde yapıldı. COVİD-19 ile ilişkili olabilecek D-dimer, fibrinojen, ferritin ve 25-OH Vitamin D'yi değerlendirdik. Hastalar, sadece polimeraz zincir reaksiyon pozitifliği (PCR +), sadece bilgisayarlı tomografi pozitifliği (CT +) ve hem PCR + hem de CT + olmak üzere üç gruba ayrıldı.
Bulgular: Yaş ortalaması 53 olan 121 hasta incelendi (% 52 erkek). Sadece CT + hastalar diğer hastalardan daha yaşlıydı (p <0.001). D-dimer, ferritin ve fibrinojen seviyeleri tüm hastalar arasında CT + olan grupta oldukça yüksekti (sırasıyla p = 0.001, p = 0.001 ve p <0.001). Hem PCR + hem de CT + olanlar ve diğerleri, CT + olanlar ve diğerleri, PCR + olanlar ve diğerleri karşılaştırıldığında D vitamini düzeyleri arasında anlamlı fark bulunamadı (p = 0.277, p = 0.350, p = 0.397). Bununla beraber tüm gruplarda D vitamini düzeylerinin yetersiz olduğu tespit edildi.
Sonuç: COVİD-19'a koagülopati eşlik edebileceğinden başvuru esnasındaki D-dimer ve fibrinojen seviyeleri öngörü sağlamaktadır. Serum ferritini ise, COVİD-19 hastalarında kötü prognoz için potansiyel risk faktörü göstergesidir.

Keywords

D-dimer , Ferritin , Fibrinojen , Vitamin D , COVİD 19 , covid-19; d-dimer; ferritin; fibrinogen; vitamin d

EVALUATION OF FEATURED BIOCHEMICAL PARAMETERS AND VITAMIN D IN COVID-19

Abstract

Aim: We aimed to evaluate potential coagulation and inflammatory biomarkers. The recently discussed vitamin D levels predict the course ef the disease and determine the patients to be admitted to the intensive care unit in advance.
Materials and Methods: This retrospective case-control study was conducted on 121 patients diagnosed and treated with COVID-19 disease, from March 2020 to June 2020 at the Amasya Sabuncuoğlu Şerefeddin Training and Research Hospital, Amasya, Turkey. D-dimer, Fibrinogen, Ferritin, and 25-OH Vitamin D levels that could be associated with COVID-19 infections were evaluated. The patients were divided into three groups: only Polymerase Chain Reaction positivity (PCR+), only Computerized Tomography positivity (CT+) and both PCR+ and CT+ among COVID-19 cases.
Results: 121 patients with at mean age of 53 were investigated (52% male). Only CT+ cases were significantly older than other patients, p<0.001. D-dimer, Ferritin, and Fibrinogen levels were considerably higher in CT+ patients among all subjects, p =0.001, p =0.001, and p<0.001, respectively. There were no apparent differences in vitamin D levels between PCR+ and CT+ and others, CT+ and, PCR+ and others, p=0.277, p=0.350, p=0.397. However, we found that vitamin D levels were deficient in all groups.
Conclusion: Since coagulopathy may accompany COVID-19, D-dimer and fibrinogen levels are predictive during admission. Serum ferritin demonstrates a potential risk factor for poor prognosis in COVID‐19 patients.

Keywords

covid-19; d-dimer; ferritin; fibrinogen; vitamin d

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