Kutanöz Malign Melanom Nedeniyle Takip Ettiğimiz Hastaların Klinikopatolojik Özellikleri

Year 2023, Volume: 14 Issue: 1, 7 - 11, 23.03.2023

Özlem Doğan , Yakup Duzkopru , Hayriye Şahinli

https://doi.org/10.18663/tjcl.1227527

Abstract

ÖZ
Amaç: Bu çalışmada, merkezimizde kutanöz malign melanom tanısı alan hastaların demografik özelliklerini, aldıkları tedavileri ve yanıtlarını incelemeyi amaçladık.
Gereç ve Yöntemler: Temmuz 2012- Haziran 2022 arasında onkoloji kliniğimizde malign melanom tanısı alan 45 hasta retrospektif olarak taranarak toplam 32 hasta çalışmaya dahil edildi. Klinik ve demografik veriler deskriptif analizlerle sunuldu. Kategorik ve numerik değişkenler sayı ve yüzde olarak verildi(n,%). PFS ve OS Kaplan-Meier metoduyla hesaplandı.
Bulgular: Çalışmaya dahil edilen hastaların 19’u(%59.4) erkek, 13’ü kadın(%40.6) idi. Hastaların median yaşı 65 (38-86) idi. Primer tümör sırasıyla 13(%40.6) hastada extremitede, 6(%18.8) hastada gövdede ve 13(% 40.6) hastada baş-boyunda yerleşimli idi. 8(%25) hastada BRAF mutasyonu mevcuttu. Hastaların 22(%68.7)’si metastatik evrede idi. Metastatik evredeki hastalarda progresyonsuz sağkalım(PFS) 5.2 ay (std. err:1.21, %95CI:2.86-7.59) iken, median genel sağkalım(OS) 23.9 (std. err:3.65, %95CI:16.8-31.11) ay idi.
Sonuç: Sonuç olarak kutanöz malign melanom en sık görülen beşinci kanserdir. İleri evrede mortalite oranları çok yüksektir ve multidisipliner takip gerekmektedir.

Keywords

Kutanöz;, Malign;, Melanom

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