The impact of timing adjuvant therapy on disease-free survival among patients with stage iib-iiia non-small cell lung cancer receiving platinum- based treatment

Year 2023, Volume: 14 Issue: 3, 639 - 644, 30.09.2023

Muslih Ürün , Yasin Sezgin , Emre Uysal

https://doi.org/10.18663/tjcl.1344051

Abstract

Aim: We aimed to investigate the relationship between time to adjuvant therapy and disease-free survival in patients with
non-small cell lung cancer who underwent curative surgical resection and received adjuvant therapy.
Material and Methods: In our study, stage IIB-IIIA patients who underwent curative surgical resection and received adjuvant therapy between 2010 and 2020 were retrospectively evaluated. They were categorized as those who started treatment before and after 6 weeks, and the time to radiologic recurrence was calculated.
Results: A total of 89 patients were included. Adjuvant treatment was started within 6 weeks after surgery in 52 patients and after 6 weeks in 37 patients. Disease-free survival was statistically significantly lower in patients who started treatment after 6 weeks (p=0.014). In addition, ECOG performance score of 0 and starting adjuvant treatment before 6 weeks were found to be independent prognostic factors in multivariate analysis (p=0.001, p=0.045).
Conclusions: In patients with NSCLC who underwent curative resection and planned adjuvant treatment, starting treatment after 6 weeks shortened disease-free survival. According to our results, it is recommended to start treatment before 6 weeks.

Keywords

Lung cancer, adjuvant, chemotherapy, disease-free survival

Adjuvant platin bazlı tedavi verilen evre ııb-ıııa küçük hücreli dışı akciğer kanseri hastalarında adjuvant tedaviye kadar geçen sürenin hastalıksız sağkalıma etkisi

Abstract

Amaç: küratif cerrahi rezeksiyon geçiren ve adjuvan tedavi verilen küçük hücreli dışı akciğer kanseri hastalarında tedaviye kadar geçen sürenin hastalıksız sağ kalımla ilişkisi
Gereç ve yöntemler: Çalışmamıza 2010-2020 yılları arasında küratif cerrahi rezeksiyon geçirmiş adjuvan tedavi alan evre IIB-IIIA hastalar alındı. Tedaviye 6 haftadan önce ve sonra başlayanlar olarak kategorize edilip radyolojik nükse kadar geçen zaman hesaplandı.
Bulgular:Toplam 89 hasta alındı. 52 hastaya tedavş 6 haftadan önce başlanmış 37 hastaya ise 6 haftdan sonra başlamış. Tedaviye 6 haftadan sonra başlanan hastalarda hastalıksız sağ kalım istatistiksel olarak anlamlı derece de daha düşüktü.
Sonuçlar: küratif rezeksiyon uygulanan adjuvan tedavi verilen küçük hücreli dışı akciğer kanseri hastalarında tedaviye 6 haftadan sonra başlamak hastalıksız sağ kalımı kısaltmıştır. Tedaviye mümkünse 6 haftadan önce başlanmalıdır

Keywords

akciğer kanseri, adjuvan, kemoterapi, hastalıksız sağkalım

Supporting Institution

destekleyen kurum yok

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