İmmunosenescence and The İmportance of İnfluenza and Pneumococcal Vaccine in Elderly?

Abstract

The vaccination of the elderly is generally ignored and their vaccination is insufficient. However, infectious diseases such as influenza and pneumococcus can be prevented or alleviated by vaccination. The "immune aging" ("immunosenescence") results in a decrease in the functions of the humoral and cellular immune systems in the elderly. Therefore, susceptibility to infections is increasing such as influenza and pneumococcus. Vaccination is effective and protective in these infections as it is important for many infections. If there is no contraindication or immunodeficiency, influenza and pneumococcal vaccinations are recommended for those aged 65 years and over by CDC (Center for Disease Control and Prevention). In this review, the importance of vactination against influenza and pneumococcal infections was discussed in the light of current studies. Yaşlıların aşılanması genel olarak göz ardı edilmekte olup aşılanmaları yetersizdir oysa influenza ve pnömokok gibi enfeksiyöz hastalıklar ve komplikasyonları, aşı ile önlenebilir ya da hafifletilebilirler. Yaşlılarda immün yaşlanma (immunosenescence) sonucu humoral ve hücresel immün sistem fonksiyonlarında azalma olmaktadır dolayısıyla/Bu nedenle influenza ve pnömokok gibi enfeksiyonlara karşı hassasiyet artmaktadır. Birçok enfeksiyon etkenine karşı aşılanmanın önemi olduğu gibi bu enfeksiyonlarda da aşılanma etkili ve koruyucudur. Eğer bir kontrendikasyon ya da immün yetmezliği yoksa CDC (Center for Disease Control and Prevention) tarafından 65 yaş ve üzeri olanlara, influenza ve pnömokok aşısı önerilmektedir. Bu derlemede, güncel çalışmalar ışığında immün yaşlanma ve bununla ilişkili olarak inflüenza ve pnömokok enfeksiyonlarına karşı aşılanmanın önemi tartışıldı.

Keywords

• Aged,İmmunosenescence,Influenza vaccines,Pneumococcal vaccines

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