EVALUATION OF INFLAMMATORY MARKERS IN CRITICALLY ILL ICU PATIENTS WITH AND WITHOUT ACUTE KIDNEY INJURY

Year 2023, , 92 - 96, 31.08.2023

Kemal Yetiş Gülsoy , Semiha Orhan

https://doi.org/10.56150/tjhsl.1284204

Abstract

Objective: Acute Kidney Injury (AKI) is a prevalent condition among patients admitted to the intensive care unit (ICU), with high incidence and increased mortality rates. AKI often induces the elevation of inflammatory biomarkers used for diagnosing infection. This study aimed to investigate changes in inflammatory markers in the setting of AKI.
Methods: This retrospective study included patients admitted to the ICUs of Burdur State Hospital between January 2019 and January 2023. Data from 958 patients were analyzed, and AKI was classified by the Acute Kidney Injury Network (AKIN) criteria. Only creatinine data were used as information on urine output was not available. The cohort was stratified into following groups: no AKI (AKI 0), b) creatine levels between 1.60 and 2.50 mg/dL (AKI I), creatine levels between 2.51 and 3.99 mg/dL (AKI II), and creatine levels above 4 and receiving renal replacement therapy (AKI III).
Results: Of the 958 patients, male and female distribution was 55.1% (n= 528) and 44.9% (n= 430) respectively. The median age of the study cohort was 79 years (IQR=18.3 years). Neutrophil-to-lymphocyte ratio, procalcitonin, and C-reactive protein levels were found to increase significantly in direct relation to the severity of AKI (p<0.001). Furthermore, in infected patients, these inflammatory biomarkers were found to increase in parallel with the severity of AKI compared to non-infected patients (p<0.001).
Conclusion: Inflammatory biomarkers rise as the severity of renal failure increases. The combined use of neutrophil-to-lymphocyte ratio, procalcitonin, and C-reactive protein levels in patients with renal failure would be more effective for diagnosing infection.

Keywords

Infection, Inflammatory Biomarker, Renal Failure, Intensive Care

Supporting Institution

No

Project Number

No

Thanks

No

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