A Case of Proteinuria Developing Secondary to Solitary Renal Vein Thrombosis Due to Oral Contraceptive Use

Abstract

Renal vein thrombosis (RVT) is the presence of thrombi in major renal veins or their branches and is a rare clinical entity. RVT is one of the common thrombotic complications of nephrotic syndrome or renal cell carcinoma. Hormonal contraception can also rarely cause this complication. Herein, we presented a case of renal vein thrombosis accompanied by subnephrotic proteinuria after oral contraception.

Keywords

• proteinuria
• renal vein trombosis
• oral contraception

References

1. Mazhar HR, Aeddula NR. Renal vein thrombosis. 2021 Jun 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Avaliable at: https://www.ncbi.nlm.nih. gov/books/NBK536971/. Accessed January 31, 2022.
2. Sasaki Y, Shimabukuro A, Isegawa T, Tamori Y, Koshiishi T, Yonaha H. Renal vein thrombosis associated with oral contraception and smoking: a case report from Japan, with literature review. CEN Case Rep. 2014 May;3(1):100-5. doi: 10.1007/s13730-013-0095-9.
3. Ajmera A, Joshi A, Kamat B, Germaine P, Weisberg L. Idiopathic acute renal vein thrombosis in a young healthy woman with no hypercoagulable state taking oral contraceptives. Am J Med Sci. 2010 Apr;339(4):380-2. doi: 10.1097/MAJ.0b013e3181ce4f34.
4. Böhler J, Hauenstein KH, Hasler K, Schollmeyer P. Renal vein thrombosis in a dehydrated patient on an oral contraceptive agent. Nephrol Dial Transplant. 1989;4(11):993-5. doi: 10.1093/ ndt/4.11.993.
5. Lidegaard Ø, Løkkegaard E, Svendsen AL, Agger C. Hormonal contraception and risk of venous thromboembolism: national follow-up study. BMJ. 2009 Aug 13;339:b2890. doi: 10.1136/bmj. b2890.
6. Chan HH, Douketis JD, Nowaczyk MJ. Acute renal vein thrombosis, oral contraceptive use, and hyperhomocysteinemia. Mayo Clin Proc. 2001 Feb;76(2):212-4. doi: 10.4065/76.2.212.
7. Girolami A, Simioni P, Girolami B, Zanardi S. The role of drugs, particularly oral contraceptives, in triggering thrombosis in congenital defects of coagulation inhibitors: a study of six patients. Blood Coagul Fibrinolysis. 1991 Oct;2(5):673-8. doi: 10.1097/00001721-199110000-00015.
8. Kim HK, Choi HH, Lee JM, Huh S. Acute renal vein thrombosis, oral contraceptives, and protein S deficiency: a successful catheter-directed thrombolysis. Ann Vasc Surg. 2009 Sep- Oct;23(5):687.e1-4. doi: 10.1016/j.avsg.2009.01.006.

9. Patole S, Ramya I. Bilateral renal vein thrombosis due to elevated factor VIII levels. J Assoc Physicians India. 2015 Aug;63(8):87-8. 10.
10. Goldman RS, Kettwich DL, Woodside JR, Borden TA. Mild unilateral proteinuria and renal vein thrombosis associated with oral contraceptive usage. Am J Kidney Dis. 1983 Jan;2(4):471-3. doi: 10.1016/s0272-6386(83)80080-8.
11. Barré P, Bishinsky J, Roy D, Roy A, Cooper B. Successful treatment with streptokinase of renal vein thrombosis associated with oral contraceptive use. Am J Nephrol. 1986;6(4):316-20. doi: 10.1159/000167182.