Comparison of the Effects of Apheresis and Pooled Platelet Transfusions on Platelet Count

Abstract

Background: To compare the increase in platelet count after the transfusion of apheresis and pooled platelet suspensions among patients in the internal medicine intensive care unit. Methods Patients who received platelet suspension transfusions and were followed up at the internal medicine intensive care unit at Mehmet Akif Inan Training and Research Hospital were evaluated. The patient's platelet counts were administered apheresis, and pooled platelet suspensions were recorded before and after transfusion. The increase in platelet count was calculated. The two groups were statistically compared. Results: A total of 4,701 platelet suspension transfusions were performed at our hospital between January 1, 2020, and December 31, 2023. Of these transfusions, 2,990 belonged to pooled platelet suspensions and 1,711 to apheresis platelet suspensions. Conclusion: Platelet suspension transfusion is frequently used in patients receiving internal medicine intensive care. However, there is an ongoing debate concerning whether apheresis or pooled platelet transfusion is more effective in increasing platelet count. In this study, we found a significantly higher increase in platelet count among patients in the internal medicine intensive care unit after apheresis platelet suspension transfusion than pooled platelet suspension transfusion.

Keywords

• Apherersis
• Transfusion
• Blood bank
• Blood type

References

1. Vatansever S, Barısık V, Omer Z, Can H. Usage of platelet suspensions. Smyrna Tıp Dergisi. 2012;3:48-53.
2. Salvadori U, Minelli C, Graziotin B, Gentilini I. Single-donor platelet apheresis: observational comparison of the new Haemonetics Universal Platelet protocol with the previous Concentrated Single Donor Platelet protocol. Blood Transfus. 2014 Apr;12(2):220-5. doi: 10.2450/2013.0119-13.
3. Pietersz RNI. Pooled platelet concentrates: an alternative to single donor apheresis platelets? Transfus Apher Sci. 2009 Oct;41(2):115-9. doi: 10.1016/j.transci.2009.07.003.
4. Fontana S, Kellerb P, Taleghanib MB. Platelet recruitment during multiple donor platelet apheresis differs between cell separators. Transfus Med Hemother. 2011;38(3):195-8. doi: 10.1159/000328634.
5. Mowat Y, Hoad V, Haire B, Masser B, Kaldor J, Heywood A, Thorpe R, McManus H, McGregor S. Prevalence of blood donation eligibility in Australia: A population survey. Transfusion. 2023 Aug;63(8):1519-27. doi: 10.1111/trf.17474.
6. Snyder EL, Elfath MD, Taylor H, Taylor H, Rugg N, Greenwalt TJ, Baril L, Whitley P, Brantigan B, Story K. Collection of two units of leukoreduced RBCs from a single donation with a portable multiple-component collection system. Transfusion. 2003 Dec;43(12):1695-705. doi: 10.1111/j.0041-1132.2003.00603.x.
7. Wollersheim J, Dautzenberg M, van de Griendt A, Sybesma B. Donor selection criteria to maximize double platelet components (DPP) by platelet apheresis. Transfus Apher Sci. 2006 Apr;34(2):179-86. doi: 10.1016/j.transci.2005.12.004.
8. Stroncek DF, Rebulla P. Platelet transfusions. Lancet. 2007 Aug 4;370(9585):427-38. doi: 10.1016/S0140-6736(07)61198-2.

9. Katus MC, Szczepiorkowski ZM, Dumont LJ, Dunbar NM. Safety of platelet transfusion: past, present and future. Vox Sang. 2014 Aug;107(2):103-13. doi: 10.1111/vox.12146.
10. Ellingson KD, Sapiano MRP, Haass KA, Savinkina AA, Baker ML, Chung KW, Henry RA, Berger JJ, Kuehnert MJ, Basavaraju SV. Continued decline in blood collection and transfusion in the United States-2015. Transfusion. 2017 Jun;57 Suppl 2(Suppl 2):1588-98. doi: 10.1111/trf.14165.
11. Rahman MM, Khan L, Saha D. Dose-and time-related platelet response with apheresis platelet concentrates and pooled platelets. Bangabandhu Sheikh Mujib Medical University Journal. 2017 Feb 25;10(1):44-7. doi: 10.3329/bsmmuj.v10i1.31667.
12. Agarwal P, Jain A, Elhence P, Verma A. Are buffy-coat pooled platelet concentrates an effective alternative to apheresis platelet concentrates? An in vitro Analysis at a tertiary care center in Northern India. Int J Appl Basic Med Res. 2023 Jul-Sep;13(3):175-9. doi: 10.4103/ijabmr.ijabmr_73_23.
13. Ness PM, Campbell-Lee SA. Single donor versus pooled random donor platelet concentrates. Curr Opin Hematol. 2001 Nov;8(6):392-6. doi: 10.1097/00062752-200111000-00013.
14. Aubron, C, Flint AW, Bailey M, Pilcher D, Cheng AC, Hegarty C, Martinelli A, Reade MC, Bellomo R, McQuilten Z. Is platelet transfusion associated with hospital-acquired infections in critically ill patients? Crit Care. 2017 Jan 6;21(1):2. doi: 10.1186/s13054-016-1593-x.