Research Article
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Clinical Presentation of Hypothyroidism in a Primary Care Cohort: An Exploratory Analysis of Gender Differences

Year 2026, Volume: 8, 4 - 11, 26.02.2026
https://doi.org/10.46310/tjim.1784722
https://izlik.org/JA98BU72CJ

Abstract

Objective: To describe patient-reported symptoms of hypothyroidism in a primary care cohort and perform an exploratory assessment of potential gender differences. Methods: This retrospective observational study included 1000 patients with confirmed hypothyroidism treated at the Public Institution Health Care Centre Visoko between January and October 2024. Data were extracted from electronic medical records. Collected variables included age, gender, comorbidities, family history, pregnancy status, and reported symptoms. Descriptive statistics were performed for the entire cohort. Exploratory logistic regression analyses were used to assess potential gender differences in reported symptoms. Results: The cohort comprised 921 (92.1%) female and 79 (7.9%) male patients, with a mean age of 57±14.6 years. The most commonly reported symptoms were hyperhidrosis (97%), fatigue (96.6%), and heart palpitations (83.5%). Male patients showed a higher likelihood of reporting heart palpitations (OR 2.42, p=0.03) and bowel problems (OR 2.03, p=0.01), and a lower likelihood of reporting neck tightness (OR 0.26, p<0.001) and tearfulness (OR 0.045, p<0.001). Conclusion: In this primary care cohort, the reported symptom burden was largely nonspecific and reflects real-world patient-reported complaints rather than classical manifestations of overt hypothyroidism. Exploratory analyses suggested potential gender-related differences; however, the low number of male patients limits firm conclusions. Larger prospective studies are needed to confirm these observations.

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There are 21 citations in total.

Details

Primary Language English
Subjects Endocrinology, ​Internal Diseases
Journal Section Research Article
Authors

Alen Omanovic This is me 0000-0001-7755-7796

Nejra Mlaco-vrazalic 0000-0002-3299-6899

Akif Mlaco 0000-0002-1907-9017

Submission Date September 15, 2025
Acceptance Date February 20, 2026
Publication Date February 26, 2026
DOI https://doi.org/10.46310/tjim.1784722
IZ https://izlik.org/JA98BU72CJ
Published in Issue Year 2026 Volume: 8

Cite

EndNote Omanovic A, Mlaco-vrazalic N, Mlaco A (February 1, 2026) Clinical Presentation of Hypothyroidism in a Primary Care Cohort: An Exploratory Analysis of Gender Differences. Turkish Journal of Internal Medicine 8 4–11.

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1. Koca N, Ersoy A, Şensoy B, Kırhan E, Güllülü S, Ersoy C, Dirican M, Sarandöl E. The association between cardiac valvular calcification and fetuin-A levels in kidney transplant recipients. Clin Exp Nephrol. 2019 Oct;23(10):1250-6. doi: 10.1007/s10157-019-01761-2.

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2. KDOQI; National Kidney Foundation. KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Anemia in Chronic Kidney Disease. Am J Kidney Dis. 2006 May;47(5suppl.3):S11-145. doi: 10.1053/j.ajkd.2006.03.010.

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3. Yıldız A, Ersoy A, Doğan S, Gül CB, Oruç A, Aktaş N, Ocakoğlu G, Ermurat S, Hartavi M, Güllülü S, Güllülü M. Evaluation of arterial stiffness after successful renal transplantation in patients with autosomal dominant polycystic kidney disease. Turkish J Nephrol. 2012;21(3):282-6 (in Turkish). doi: 10.5262/tndt.2012.1003.14.

Complete book
4. Gouveia C, Melo D, eds. Weight Change: Patterns, Risks and Psychosocial Effects. 1st ed. New York, NY: Nova Science Publishers; 2012.

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Item presented at a meeting but not yet published
6. Imamoğlu Ş, Orhan B, Aydınlar A, Ertürk E, Tuncel E, Ersoy A, Arınık A. Changes of cardiac functions after the therapy of hyperthyroid and hypothyroid patients. Poster presented at: The Endocrine Society, 76th Annual Meeting; June 15-18, 1994; Anaheim, CA.

Published meeting abstract
7. Kanat FM, Kordan Y, Kaygisiz O, Coskun B, Vuruskan H, Oruc A, Yildiz A, Ayar Y, Ersoy A. The effect of renal arterial anastomosis techniques on the development of complications and graft dysfunction in recipients after kidney transplantation [ERA-EDTA abstract SP760]. Nephrol Dial Transplant. 2017 May 26;32(suppl.3):iii400. doi: https://doi.org/10.1093/ndt/gfx157.SP760.

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8. University of Alabama School of Medicine. Interagency Registry for Mechanical Circulatory Support. Available at: www.uab.edu/intermacs. Accessed April 13, 2012.

Unpublished specialty thesis in medicine/master thesis / doctoral dissertation
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10. Editors should ensure that all research material they publish conforms to international accepted ethical guidelines.
11. Editors should only accept a paper when reasonably certain.
12. Editors should act if they suspect misconduct, whether a paper is published or unpublished, and make all reasonable attempts to persist in obtaining a resolution to the problem.
13. Editors should not reject papers based on suspicions; they should have proof of misconduct.
14. Editors should not allow any conflicts of interest between staff, authors, reviewers, and board members.
15. Editors must not change their decision after submitting a decision (especially after reject or accept) unless they have a serious reason.

Section E: Publishing Ethics Issues

Editorial Board of the Turkish Journal of Internal Medicine complies with the criteria of the International Council of Medical Journal Editors (ICMJE), the World Association of Medical Editors (WAME), and Committee on Publication Ethics (COPE).
1. All editorial members, reviewers, and authors must confirm and obey rules defined by COPE.
2. The corresponding author is the main owner of the article so she/he can withdraw the article when it is incomplete (before entering the review process or when a revision is asked for).
3. Authors cannot make major changes in the article after acceptance without a serious reason.
4. All editorial members and authors must will to publish any kind of corrections honestly and completely.
5. Any notes of plagiarism, fraudulent data, or any other kinds of fraud must be reported completely to COPE.

• Turkish Journal of Internal Medicine (TJIM) does not charge any fees for manuscript submission, peer review, editorial handling, page layout/typesetting, or publication (including page or color charges).
• TJIM does not provide any payments or honoraria to authors, reviewers, editors, or editorial board members.
• All published articles are freely accessible to read and download.
• TJIM is an open-access journal and does not require any subscription fees for access.
• All TJIM content is digitally archived and preserved via the LOCKSS (Lots Of Copies Keep Stuff Safe) system through TÜBİTAK ULAKBİM DergiPark.
• In line with the journal’s publication policy, announcements, advertisements, sponsorships, and similar content are neither accepted nor published.
• TJIM does not offer a reprint service for professional-quality reproductions of articles.
• All expenses of TJIM are covered by the publisher.

Editor-in-Chief

Editorial Board

Gastroenterology and Hepatology
Chest Diseases
Cardiology
​Internal Diseases, Health Sciences
Endocrinology, ​Internal Diseases
​Internal Diseases, Clinical Oncology, Oncology and Carcinogenesis, Cancer Genetics, Predictive and Prognostic Markers
Haematology, ​Internal Diseases
Radiology and Organ Imaging

36536

e-ISSN: 2687-4245 

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