An Unforgettable Pre-Diagnosis for an Elderly Patient with Renal Failure and Back Pain: Multiple Myeloma

Year 2021, , 55 - 56, 07.03.2021

Ece Ünal Çetin , Adil Uğur Çetin

https://doi.org/10.46310/tjim.875351

Abstract

Multiple myeloma is a malignant disease that can result in organ damage due to abnormal plasma cell growth and immunoglobulin or light chain overproduction in the bone marrow. It is the second most common hematologic cancer after lymphomas. Approximately half of the patients have kidney failure. Bone involvement is one of the most common organ damage in myeloma. Bone involvement is a feature that has diagnostic and prognostic value, shows tumor burden, organ damage, and affects the patient's quality of life. With the recent advances in Multiple Myeloma treatment, the survival of patients has increased dramatically. Although new agents contribute positively to total survival and disease-free life span, they cannot prevent disease recurrence. Therefore, it should be considered in patients with back pain, anemia, and kidney failure, and treatment delay should be avoided.

Keywords

multiple myeloma, renalfailure, back pain

References

• 1.Rajkumar SV, Dimopoulos MA, Palumbo A, et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol. 2014;15:538-48.
• 2. Kyle RA. Multiple myeloma: revive of 869 cases. Mayo Clinic Proc 1975;50: 29-40.
• 3.Kyle RA, Gertz MA, Witzing TE, et al. Reviewof 1027 patients with newly diagnosed multiple myeloma. Mayo Clinic Proc 2003;78:21-33.
• 4.Kapadia SB. Multiple myeloma: a clinicopathologic studyof 62 consecutively autopsied cases . Medicine(Balt) 1980; 59: 380-392.
• 5. Blade J, Fernandez-Llama P, Bosch F, et al. Renal Failure in multiple myeloma: presenting features and predictors of outcome in 94 patient from a single institution. Acrh Intern Med 1998; 158: 1889-1893.
• 6. Knudsen LM, Hippe E, Hjort M, et al. Renal function in newly diagnosed multiple myeloma – a demographic study of 1353 patients. The Nordic Myeloma Study Group. Eur J Haematol 1994; 53: 207-212.
• 7. Irish AB, Winearls CG, Littlewood T. Presentation and survival of patients with severe renal failure and nyeloma. Q J Med 1997;90: 773-780.
• 8. Kyle RA, Therneau TM, Rajkumar SV, et al. Incidence of multiple myeloma in Olmsted County, Minnesota: trend over 6 decades. Cancer. 2004; 101:2667-74.