Polypharmacy and potential inappropriate drug use in the elderly admitted to the general internal medicine outpatient clinic

Year 2021, Volume: 3 Issue: Supplement 1, 46 - 48, 07.03.2021

Celaleddin Demircan , Ulviyya Hasanzade

https://doi.org/10.46310/tjim.879724

Cited By: 2

https://izlik.org/JA89FW89AF

Abstract

In this study, we aimed to investigate the rates of polypharmacy and potentially inappropriate drug (PID) use in elderly patients who admitted to General Internal Medicine Outpatient Clinic. In this prospective cross-sectional study, the frequency of chronic diseases, the number of drugs used and polypharmacy rates of elderly patients were determined. Then, PIDs rates were investigated according to the 2015 Beers criteria. 304 (58,9% female, 41,1% male) patients were included in the study. 95,8% had at least one concomitant chronic disease, the mean number of drugs used by the patients per day was 4,9 ± 3,3 and the rate of polypharmacy was 52,9%. A total of 124 PIDs were determined in 104 (34,2%) patients, and this rate was higher in patients with polypharmacy (p < 0,05). The most common PIDs; the use of drugs that should be avoided in the elderly (Table 2-related PIDs; 28,3%), and the most common of these was the inappropriate use of proton pump inhibitors (PPIs).

Keywords

polypharmacy , potential inappropriate drug , elderly

References

• 1.Nobili A, Garattini S, Mannucci PM. Multiple diseases and polypharmacy in the elderly: challenges for the internist of the third millennium. J Comorb 2011;1:28-44.
• 2.Hanlon JT, Lindblad CI, Hajjar ER, McCarthy TC. Update on drug related problems in the elderly. Am J Geriatr Pharmacother 2003;1:38-43.
• 3.Kaufmann DW, Keelly JP, Rosenberg L, Anderson TE, Mitchell AA. Recent pattern of medication use in the ambulatory adult population of the United States. The Slone Survey. JAMA 2002;287:337-344.
• 4.American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. AGS 2015 Beers Criteria Update Expert Panel. J Am Geriatr Soc 2015;63:2227-2246.
• 5.Bahat G, Tufan F, Bahat Z, et al. Comorbidities, polypharmacy, functionality and nutritional status in Turkish community-dwelling female elderly. Aging Clin Exp Res 2014;26:255-259. (DOI 10.1007/s40520-014-0229-8).
• 6.Gocer S, Gunay O, Polat T, Ulutabanca RO, Sonkaya ZI. Polypharmacy and associated factors in people living in a nursing home in Kayseri Turkey. Medicine Science 2017;6(4):646-652.
• 7.Viktil KK, Blix HS, Moger TA, Reikvam A. Polypharmacy as commonly defined is an indicator of limited value in the assessment of drug-related problems. Br J Clin Pharmacol 2007;63(2):187-195.
• 8.Nobili A, Licata G, Salerno F, et al. Polypharmacy, length of hospital stay, and in-hospital mortality among elderly patients in internal medicine wards. The REPOSI study. Eur J Clin Pharmacol 2011;67:507-519. (DOI 10.1007/s00228-010-0977-0).
• 9.Chun JC, Appel SJ, Simmons S. 2015 Beers Criteria Medication Review in Assisted Living Facilities. J Am Assoc Nurse Pract 2018;30(11):648-654. (DOI: 10.1097/JXX.0000000000000082).
• 10.Bulatova N, Elayeh E, Abdullah S, et al. Assessment of ınapproprıate medıcatıon use ın Jordanıan elderly hospıtalızed patıents usıng 2015 Beers crıterıa. Turkish Journal of Geriatrics 2019;22(3):258-268. (DOI: 10.31086/tjgeri.2019.101).