Endogenous Obesity Associated with Cushing’s Disease: A Case Report

Abstract

Cushing’s disease (CD) constitutes most common cases of adrenocorticotropic hormone (ACTH) dependent Cushing’s syndrome (CS). CD more often occurs in women. Recent studies indicate increasing prevalence of CD amongst the obese people. Therefore, the possibility of underlying CD should be ruled out in obese people. Inferior petrosal sinus sampling (IPSS) is an important diagnostic method for diagnosing and localizing CD cases who can’t be diagnosed by standard imaging methods. IPSS can increase the success of the surgeon's treatment with information about the location of the adenoma. Here, we present a case of a 36-year-old female patient admitted to the hospital for bariatric surgery who was diagnosed having CD localized by IPSS.

Keywords

• Cushing’s disease
• Inferior petrosal venous sinus sampling
• Endogenous obesity

References

1. Sharma ST, Nieman LK, Feelders RA. Cushing’s syndrome: epidemiology and developments in disease management. Clin Epidemiol. 2015; 7: 281–293 doi: 10.2147/CLEP.S44336
2. Lim JH , Kim SJ , Jung MK et al. A patient with Cushing disease lateralizing a pituitary adenoma by inferior petrosal sinus sampling using desmopressin: a case report. Ann Pediatr Endocrinol Metab. 2016 Mar; 21(1): 43–46 doi: 10.6065/apem.2016.21.1.43
3. Buliman A, Tataranu LG, Paun DL, Mirica A and Dumitrache C. Cushing’s disease: a multidisciplinary overview of the clinical features, diagnosis, and treatment. J Med Life. 2016 Jan-Mar; 9(1): 12–18. PMID: 27974908
4. Tanrıöver N, Günaldı Ö, Kuruoğlu E. Cushing’s disease and surgical treatment. Türk Nöroşir Derg 2014; 24(3): 83-92