Year 2019, Volume 1 , Issue 1, Pages 15 - 20 2019-10-29

Evaluation of the effects of diabetes mellitus and metformin usage on serum vitamin B12 levels in cobalamin deficient subjects

Duygu Nurdan AVCI [1] , Canan ERSOY [2]


Introduction:Although there are studies evaluating vitamin B12 levels in different patient groups, there is none encountered in Turkish adult patients with or without DM reported in the English literature.The aim of the study was to evaluate the possible additional effects of diabetes and metformin usage on serum levels of vitamin B12 in cobalamin deficient Turkish adult patients. 

Material and Methods:Medical records of subjects ≥18 years of age, having a vitamin B12 level <180 pg/mL were screened, consecutive 98 subjects were included in the study. 

Results:Among a total of 75 female and 23 male subjects with a mean age of 51.3±15.9 years and vitamin B12 level of 139.3±29.2 pg/mL, 34 had the diagnosis of type 2 diabetes mellitus and 64 had no diabetes diagnosis. Mean ages were 59.0±10.8 years for diabetics and 47.2±16.8 years for nondiabetics. Vitamin B12 levels were found to be insignificantly low in people with the diagnosis of diabetes compared to without diabetes (131.2±30.6 and 143.5±27.7 pg/mL, respectively, p=0.05). Vitamin B12 levels had no correlation with diabetes duration, presence of complications, metformin usage duration. 

Conclusions:In conclusion, our results demonstrated that people with diabetes had lower levels of vitamin B12 compared to nondiabetics but this fact could not solely be explained by the duration of disease, accompanying complications, metformin treatment duration. All patients with or without the diagnosis of diabetes should be encouraged for sufficient vitamin B12 intake and all possible factors that lead to deficiency should be eliminated.

vitamin B12 deficiency, metformin, diabetes mellitus
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Primary Language en
Journal Section Original Articles

Orcid: 0000-0001-7328-2422
Author: Duygu Nurdan AVCI (Primary Author)
Institution: Department of Internal Medicine, Uludağ University Medical School, Bursa, Turkey
Country: Turkey

Orcid: 0000-0003-4510-6282
Author: Canan ERSOY
Institution: Department of Internal Medicine, Division of Endocrinology and Metabolism, Uludağ University Medical School, Bursa, Turkey
Country: Turkey


Application Date : October 10, 2019
Acceptance Date : October 24, 2019
Publication Date : October 29, 2019

EndNote %0 Turkish Journal of Internal Medicine Evaluation of the effects of diabetes mellitus and metformin usage on serum vitamin B12 levels in cobalamin deficient subjects %A Duygu Nurdan Avcı , Canan Ersoy %T Evaluation of the effects of diabetes mellitus and metformin usage on serum vitamin B12 levels in cobalamin deficient subjects %D 2019 %J Turkish Journal of Internal Medicine %P -2687-4245 %V 1 %N 1 %R doi: 10.46310/tjim.631821 %U 10.46310/tjim.631821