Effect of conversion from azathioprine to mycophenolate mofetil on renal function in stable kidney transplant recipients

Year 2019, Volume: 1 Issue: 1, 21 - 25, 29.10.2019

Mehmet Usta , Alparslan Ersoy , Yavuz Ayar

https://doi.org/10.46310/tjim.632066

Abstract

Abstract

Aim: This study investigated the effect of mycophenolate mofetil (MPA) treatment instead of azathioprine (AZA) on renal function after kidney transplantation. 

Methods: Thirteen of all recipients were taking a cyclosporine-based regimen and serum creatinine levels were above 1.5 mg/dL. In 13 patients, MPA treatment was started instead of AZA. Renal functions were evaluated for 12 months after MPA treatment. 

Results: Serum creatinine levels increased from 2.11±0.48 mg/dL to 2.16±0.72 mg/dL at 12th months. This increase was not statistically significant. Serum creatinine levels decreased in 5 of 13 patients. 

Conclusion: In selected patients, conversion from AZA to MPA may slow down the rate of deterioration in graft functions.

Keywords

azathioprine, mycophenolate mofetil, kidney transplantation recipient

Supporting Institution

ULUDAG UNIVERSITY

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