Year 2019, Volume 1 , Issue 1, Pages 21 - 25 2019-10-29

Effect of conversion from azathioprine to mycophenolate mofetil on renal function in stable kidney transplant recipients

Mehmet USTA [1] , Alparslan ERSOY [2] , Yavuz AYAR [3]


Abstract

Aim: This study investigated the effect of mycophenolate mofetil (MPA) treatment instead of azathioprine (AZA) on renal function after kidney transplantation. 

Methods: Thirteen of all recipients were taking a cyclosporine-based regimen and serum creatinine levels were above 1.5 mg/dL. In 13 patients, MPA treatment was started instead of AZA. Renal functions were evaluated for 12 months after MPA treatment. 

Results: Serum creatinine levels increased from 2.11±0.48 mg/dL to 2.16±0.72 mg/dL at 12th months. This increase was not statistically significant. Serum creatinine levels decreased in 5 of 13 patients. 

Conclusion: In selected patients, conversion from AZA to MPA may slow down the rate of deterioration in graft functions.

azathioprine, mycophenolate mofetil, kidney transplantation recipient
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Primary Language en
Journal Section Original Articles
Authors

Orcid: 0000-0003-2355-1203
Author: Mehmet USTA (Primary Author)
Institution: Bursa City Hospital, Nephrology Clinic, Bursa
Country: Turkey


Orcid: 0000-0002-0710-0923
Author: Alparslan ERSOY
Institution: Uludag University Faculty of Medicine, Department of Nephrology, Bursa
Country: Turkey


Orcid: 0000-0003-4607-9220
Author: Yavuz AYAR
Institution: Bursa City Hospital, Nephrology Clinic, Bursa
Country: Turkey


Supporting Institution ULUDAG UNIVERSITY
Dates

Application Date : October 11, 2019
Acceptance Date : October 22, 2019
Publication Date : October 29, 2019

EndNote %0 Turkish Journal of Internal Medicine Effect of conversion from azathioprine to mycophenolate mofetil on renal function in stable kidney transplant recipients %A Mehmet Usta , Alparslan Ersoy , Yavuz Ayar %T Effect of conversion from azathioprine to mycophenolate mofetil on renal function in stable kidney transplant recipients %D 2019 %J Turkish Journal of Internal Medicine %P -2687-4245 %V 1 %N 1 %R doi: 10.46310/tjim.632066 %U 10.46310/tjim.632066