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Uric acid levels and clearance in chronic kidney disease patients

Year 2020, Volume: 2 Issue: 1, 19 - 21, 29.01.2020
https://doi.org/10.46310/tjim.676419

Abstract

Aim: Uric acid levels increase in chronic renal failure especially due to protein metabolism. In this study, we aimed to compare uric acid clearance who are also nephrotoxic in patients with end-stage renal disease.

Methods: Sixty-one chronic peritoneal dialysis (PD) patients and fifty-one chronic hemodialysis (HD) patients included in the study. Duration of PD and HD, uric acid levels, age and gender of the patients evaluated. Uric acid levels in PD patients and HD patients compared.

Results: The mean ages of PD and HD patients were 56.77 ±13.58 and 57.25 ± 16.45 years, respectively (p=0.864). The number of male patients was more in the PD group and female in the HD group (p=0.959). The duration of dialysis was 3.25 in PD, 3.75 in HD (p=0.925). The mean uric acid levels were 5.54 ± 1.13 mg/dL in PD patients, and 5.76 ±1.52 mg/dL in HD patients (p=0.389).

Conclusion: Dialysis is used to remove toxins in end-stage renal disease. Uric acid levels may be elevated in patients with end-stage renal disease. There is no difference in uric acid clearance in PD and HD patients.

Project Number

Yok

References

  • 1-Chonchol M, Shlipak MG, Katz R, et al.Relationship of uric acid whit progretion of kidney diseasre . Am J Kidney Dis 2007;50:239-40. 2- Harrison R. Structure and function of xanthine oxidoreductase : where are we now? Free Biol Med. 2002; 33:774 -9. 3- Sautin YY, Johnson RJ . Uric: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids. 2008;27:608-19. 4-Park C,Obi Y, Streja E, Rhee CM, Catabay CJ, Vaziri ND, Kovesdy CP, Kalantar- Zadeh K. Serum uric , protein intake and mortality in hemodialysis patients. Nephrol Dial Transplant. 2017;32:1750-7. 5- Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J,Watanabe S, Tuttle KR, Rodriguez-Iturbe B, Herrera – Acosta J, Mazzali M.Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension. 2003;41:1183-90. 6- Shankar A, Klein BE, Nieto FJ, Klein R. Association between serum uric acid level and peripheral arterial disease. Atherosclerosis. 2008;196:749-55. 7- Jonasson T, Ohlin AK, Gottsater A, Hultberg B, Ohlin H. Plasma homocysteine and markers for axidative stress and inflammation in patients wits coronary artery disease—a prospective randomized study of vitamin supplementation. Clin Chem Lab Med. 2005;43:628-34. 8- Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovasküler risk. N Engl J Med. 2008;359:1811-21. 9- Bandaru P, Shankar A, Association between serum uric acid levels and diabetes melllitus. Int Endocrinol .2011;2011:604715 10- Feig DI. Uric acid: a novel mediator and marker of risk in choronic kidney disease? Curr Opin Nephrol Hypertens. 2009;18:526-30. 11-Petreski T, Bevc S, Ekart R, Hojs R. Hyperuricemia and long-term survival in patients with chronic kidney disease undergoing hemodialysis. Clin Nephrol. 2017;88:69-72. 12- Latif W, Karaboyas A, Tong L, Winchester JF , Arrington CJ, Pisoni RL, Marshall MR, Kleophas W, Levin NW, Sen A, et al. Uric acid levels and all-cause and cardivascular moratlity in the hemodialysis population. Clin J Am Soc Nephrol.2011;6:2470-7. 13- Beberashvili I, Erlich A, Azar A, Sinuani I, Feldman L, Gorelik O, Stav K, Efrati S. Longitudinal study of serum uric nutritional status, and mortality in maintenance hemodialysis patients. Clin J Am Soc Nephrol. 2016;11(6):1015-23. 14- Hsu SP, Pai MF, Peng YS, Chiang CK , Ho Tl, Hung KY. Serum uric acid levels show a’J-shaped’ association with all-cause mortality in hemodialysis patients. Nephrol Dial Transplant.2004;19:457-62. 15- Feng S, Jiang L, Shi Y, Shen H, Shi X, Jin D, Zeng Y, Wang Z. Uric acid levels and all- cause mortality in peritoneal dialysis patients. Kidney Blood Press Res. 2013;37:181-9. 16- Xia X , He F, Wu X, Peng F, Huang F, Yu X. Relayionship between serum uric acid and all-cause and caediovascular moratlity in patients. Kidney Blood Press Res. 2013;37:181-9. 17- Lai Kuan- Ju, Kor Chew- Teng. :Hsieh Yao-Peng. An Inverse Realitionship between Hyeruricemia and Mortality in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis. Journal af Clinical Medicine.2018 ;7(11):416. 18-Park C, Obi Y, Streja E, Rhee CM, Catabay CJ, Vaziri ND, KovestY CP, Kalantar Zadeh K, Serum uric acid protein intake mortality in hemodialysis patients. Nephrol Dial Transplant. 2017; 32:1750-1757.
Year 2020, Volume: 2 Issue: 1, 19 - 21, 29.01.2020
https://doi.org/10.46310/tjim.676419

Abstract

Supporting Institution

Yok

Project Number

Yok

Thanks

Teşekkür ederim

References

  • 1-Chonchol M, Shlipak MG, Katz R, et al.Relationship of uric acid whit progretion of kidney diseasre . Am J Kidney Dis 2007;50:239-40. 2- Harrison R. Structure and function of xanthine oxidoreductase : where are we now? Free Biol Med. 2002; 33:774 -9. 3- Sautin YY, Johnson RJ . Uric: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids. 2008;27:608-19. 4-Park C,Obi Y, Streja E, Rhee CM, Catabay CJ, Vaziri ND, Kovesdy CP, Kalantar- Zadeh K. Serum uric , protein intake and mortality in hemodialysis patients. Nephrol Dial Transplant. 2017;32:1750-7. 5- Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J,Watanabe S, Tuttle KR, Rodriguez-Iturbe B, Herrera – Acosta J, Mazzali M.Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension. 2003;41:1183-90. 6- Shankar A, Klein BE, Nieto FJ, Klein R. Association between serum uric acid level and peripheral arterial disease. Atherosclerosis. 2008;196:749-55. 7- Jonasson T, Ohlin AK, Gottsater A, Hultberg B, Ohlin H. Plasma homocysteine and markers for axidative stress and inflammation in patients wits coronary artery disease—a prospective randomized study of vitamin supplementation. Clin Chem Lab Med. 2005;43:628-34. 8- Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovasküler risk. N Engl J Med. 2008;359:1811-21. 9- Bandaru P, Shankar A, Association between serum uric acid levels and diabetes melllitus. Int Endocrinol .2011;2011:604715 10- Feig DI. Uric acid: a novel mediator and marker of risk in choronic kidney disease? Curr Opin Nephrol Hypertens. 2009;18:526-30. 11-Petreski T, Bevc S, Ekart R, Hojs R. Hyperuricemia and long-term survival in patients with chronic kidney disease undergoing hemodialysis. Clin Nephrol. 2017;88:69-72. 12- Latif W, Karaboyas A, Tong L, Winchester JF , Arrington CJ, Pisoni RL, Marshall MR, Kleophas W, Levin NW, Sen A, et al. Uric acid levels and all-cause and cardivascular moratlity in the hemodialysis population. Clin J Am Soc Nephrol.2011;6:2470-7. 13- Beberashvili I, Erlich A, Azar A, Sinuani I, Feldman L, Gorelik O, Stav K, Efrati S. Longitudinal study of serum uric nutritional status, and mortality in maintenance hemodialysis patients. Clin J Am Soc Nephrol. 2016;11(6):1015-23. 14- Hsu SP, Pai MF, Peng YS, Chiang CK , Ho Tl, Hung KY. Serum uric acid levels show a’J-shaped’ association with all-cause mortality in hemodialysis patients. Nephrol Dial Transplant.2004;19:457-62. 15- Feng S, Jiang L, Shi Y, Shen H, Shi X, Jin D, Zeng Y, Wang Z. Uric acid levels and all- cause mortality in peritoneal dialysis patients. Kidney Blood Press Res. 2013;37:181-9. 16- Xia X , He F, Wu X, Peng F, Huang F, Yu X. Relayionship between serum uric acid and all-cause and caediovascular moratlity in patients. Kidney Blood Press Res. 2013;37:181-9. 17- Lai Kuan- Ju, Kor Chew- Teng. :Hsieh Yao-Peng. An Inverse Realitionship between Hyeruricemia and Mortality in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis. Journal af Clinical Medicine.2018 ;7(11):416. 18-Park C, Obi Y, Streja E, Rhee CM, Catabay CJ, Vaziri ND, KovestY CP, Kalantar Zadeh K, Serum uric acid protein intake mortality in hemodialysis patients. Nephrol Dial Transplant. 2017; 32:1750-1757.
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Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Original Articles
Authors

Mehmet Usta 0000-0003-4607-9220

Yavuz Ayar 0000-0003-4607-9220

Project Number Yok
Publication Date January 29, 2020
Submission Date January 17, 2020
Acceptance Date January 22, 2020
Published in Issue Year 2020 Volume: 2 Issue: 1

Cite

EndNote Usta M, Ayar Y (January 1, 2020) Uric acid levels and clearance in chronic kidney disease patients. Turkish Journal of Internal Medicine 2 1 19–21.

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