Case Report
BibTex RIS Cite

Markedly elevated lipase as the first manifestation of celiac disease: Case Report

Year 2021, Volume: 3 Issue: 2, 80 - 84, 29.04.2021
https://doi.org/10.46310/tjim.814732

Abstract

Lipase is a hydrolytic enzyme and commonly used for the diagnosis of pancreatitis with amylase. Except for pancreatitis, lipase is elevated in many clinical conditions such as hepatobiliary disorders, bowel diseases, malignancies, renal impairment. Celiac disease (CD) should be considered as one of the causes. In patients with CD, the frequency of pancreatic hyperenzymemia and possible pathophysiological mechanisms are not well studied. To date, several mechanisms explaining pancreatic hyperenzymemia in CD are reported. Malnutrition, disease bowel induced pancreatic dysfunction, autoimmune pancreatic inflammation, and macroenzymemia are the main ones. Herein, we report a patient with newly diagnosed CD, representing markedly elevated serum lipase level with normal amylase.

Supporting Institution

-

Project Number

-

Thanks

-

References

  • 1. Frulloni L, Patrizi F, Bernardoni L, Cavallini G. Pancreatic hyperenzymemia: Clinical significance and diagnostic approach.JOP. 2005 ;6:536-51.
  • 2. Holmes GK. Non-malignant complications of coeliac disease. Acta Paediatr Suppl. 1996;412:68-75.
  • 3. Carroccio A, Di Prima L, Scalici C, Soresi M, CefalÙ AB, Noto D, et al. Unexplained elevated serum pancreatic enzymes: A reason to suspect celiac disease. Clin Gastroenterol Hepatol. 2006;4:455–9.
  • 4. Hameed AM, Lam VWT, Pleass HC. Significant elevations of serum lipase not caused by pancreatitis: A systematic review. Hpb. 2015;17:99–112.
  • 5. Migliori M, Galassi E, Gullo L. Search for celiac disease in subjects with asymptomatic pancreatic hyperenzymemia. Pancreas. 2011;40:979-81.
  • 6. Freeman HJ. Celiac-associated pancreatic disease. Ann Gastroenterol. 2016;29:241-2.
  • 7. Lauret E, Rodrigo L. Celiac disease and autoimmune-associated conditions. Biomed Res Int. 2013;2013:127589
  • 8. Di Sabatino A, Corazza GR. Coeliac disease. Lancet. 2009;373:1480-93.
  • 9. Rabsztyn A, Green PH, Berti I, Fasano A, Perman JA, Horvath K. Macroamylasemia in patients with celiac disease. Am J Gastroenterol. 2001;96:1096
  • 10. Garcia‐Gonzalez M, Defarges‐Pons V, Monescillo A, Hernandez F, Cano‐Ruiz A. Macrolipasemia and celiac disease. Am J Gastroenterol. 1995;90:2233-4.
Year 2021, Volume: 3 Issue: 2, 80 - 84, 29.04.2021
https://doi.org/10.46310/tjim.814732

Abstract

Project Number

-

References

  • 1. Frulloni L, Patrizi F, Bernardoni L, Cavallini G. Pancreatic hyperenzymemia: Clinical significance and diagnostic approach.JOP. 2005 ;6:536-51.
  • 2. Holmes GK. Non-malignant complications of coeliac disease. Acta Paediatr Suppl. 1996;412:68-75.
  • 3. Carroccio A, Di Prima L, Scalici C, Soresi M, CefalÙ AB, Noto D, et al. Unexplained elevated serum pancreatic enzymes: A reason to suspect celiac disease. Clin Gastroenterol Hepatol. 2006;4:455–9.
  • 4. Hameed AM, Lam VWT, Pleass HC. Significant elevations of serum lipase not caused by pancreatitis: A systematic review. Hpb. 2015;17:99–112.
  • 5. Migliori M, Galassi E, Gullo L. Search for celiac disease in subjects with asymptomatic pancreatic hyperenzymemia. Pancreas. 2011;40:979-81.
  • 6. Freeman HJ. Celiac-associated pancreatic disease. Ann Gastroenterol. 2016;29:241-2.
  • 7. Lauret E, Rodrigo L. Celiac disease and autoimmune-associated conditions. Biomed Res Int. 2013;2013:127589
  • 8. Di Sabatino A, Corazza GR. Coeliac disease. Lancet. 2009;373:1480-93.
  • 9. Rabsztyn A, Green PH, Berti I, Fasano A, Perman JA, Horvath K. Macroamylasemia in patients with celiac disease. Am J Gastroenterol. 2001;96:1096
  • 10. Garcia‐Gonzalez M, Defarges‐Pons V, Monescillo A, Hernandez F, Cano‐Ruiz A. Macrolipasemia and celiac disease. Am J Gastroenterol. 1995;90:2233-4.
There are 10 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Case Reports
Authors

Ahmet Bilgehan Şahin 0000-0002-7846-0870

Fazıl Hunutlu This is me 0000-0002-4991-9830

Nesrin Uğraş This is me 0000-0003-0127-548X

Macit Gülten 0000-0002-4186-0731

Project Number -
Publication Date April 29, 2021
Submission Date October 22, 2020
Acceptance Date January 14, 2021
Published in Issue Year 2021 Volume: 3 Issue: 2

Cite

EndNote Şahin AB, Hunutlu F, Uğraş N, Gülten M (April 1, 2021) Markedly elevated lipase as the first manifestation of celiac disease: Case Report. Turkish Journal of Internal Medicine 3 2 80–84.

e-ISSN: 2687-4245 

Turkish Journal of Internal Medicine, hosted by Turkish JournalPark ACADEMIC, is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

by-nc-nd.png
2024 -TJIM.org