Research Article
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Year 2023, Volume: 5 Issue: 2, 135 - 140, 29.04.2023
https://doi.org/10.46310/tjim.1169467

Abstract

References

  • Robert-Ebadi H, Righini M. D-dimer: Well beyond diagnosis! J Med Vasc. 2020 Sep;45(5):239-40. doi: 10.1016/j.jdmv.2020.06.006.
  • Lim W, Le Gal G, Bates SM, Righini M, Haramati LB, Lang E, Kline JA, Chasteen S, Snyder M, Patel P, Bhatt M, Patel P, Braun C, Begum H, Wiercioch W, Schünemann HJ, Mustafa RA. American Society of Hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism. Blood Adv. 2018 Nov 27;2(22):3226-56. doi: 10.1182/bloodadvances.2018024828.
  • Iwuji K, Almekdash H, Nugent KM, Islam E, Hyde B, Kopel J, Opiegbe A, Appiah D. Age-adjusted D-dimer in the prediction of pulmonary embolism: Systematic review and meta-analysis. J Prim Care Community Health. 2021 Jan-Dec;12:21501327211054996. doi: 10.1177/21501327211054996.
  • Crawford F, Andras A, Welch K, Sheares K, Keeling D, Chappell FM. D-dimer test for excluding the diagnosis of pulmonary embolism. Cochrane Database Syst Rev. 2016 Aug 5;2016(8):CD010864. doi: 10.1002/14651858.CD010864.pub2.
  • Senior K, Burles K, Wang D, Grigat D, Innes GD, Andruchow JE, Lang ES, McRae AD. Age-adjusted D-dimer thresholds in the investigation of suspected pulmonary embolism: A retrospective evaluation in patients ages 50 and older using administrative data. CJEM. 2018 Sep;20(5):725-31. doi: 10.1017/cem.2018.389.
  • Turak O, Canpolat U, Ozcan F, Yayla C, Mendi MA, Oksüz F, Tok D, Tok D, Cağlı K, Gölbaşı Z. D-dimer level predicts in-hospital mortality in patients with infective endocarditis: a prospective single-centre study. Thromb Res. 2014 Sep;134(3):587-92. doi: 10.1016/j.thromres.2014.06.015.
  • Mélé N, Turc G. Stroke associated with recent mycoplasma pneumoniae infection: A systematic review of clinical features and presumed pathophysiological mechanisms. Front Neurol. 2018 Dec 21;9:1109. doi: 10.3389/fneur.2018.01109.
  • Yao J, Bai T, Yang B, Sun L. The diagnostic value of D-dimer in acute aortic dissection: a meta-analysis. J Cardiothorac Surg. 2021 Nov 27;16(1):343. doi: 10.1186/s13019-021-01726-1.
  • Sakka M, Connors JM, Hékimian G, Martin-Toutain I, Crichi B, Colmegna I, Bonnefont-Rousselot D, Farge D, Frere C. Association between D-Dimer levels and mortality in patients with coronavirus disease 2019 (COVID-19): a systematic review and pooled analysis. J Med Vasc. 2020 Sep;45(5):268-74. doi: 10.1016/j.jdmv.2020.05.003.
  • Yang C, Zeng HH, Huang J, Zhang QY, Lin K. Predictive roles of D-dimer for mortality of patients with community-acquired pneumonia: a systematic review and meta-analysis. J Bras Pneumol. 2021 Dec 15;47(6):e20210072. doi: 10.36416/1806-3756/e20210072.
  • Rodelo JR, De la Rosa G, Valencia ML, Ospina S, Arango CM, Gómez CI, García A, Nuñez E, Jaimes FA. D-dimer is a significant prognostic factor in patients with suspected infection and sepsis. Am J Emerg Med. 2012 Nov;30(9):1991-9. doi: 10.1016/j.ajem.2012.04.033.
  • Li J, Wang Y, Li J, Che G. Prognostic value of pretreatment D-Dimer level in small-cell lung cancer: A meta-analysis. Technol Cancer Res Treat. 2021 Jan-Dec;20:1533033821989822. doi: 10.1177/1533033821989822.
  • Abdelaal Ahmed Mahmoud M Alkhatip A, Donnelly M, Snyman L, Conroy P, Hamza MK, Murphy I, Purcell A, McGuire D. YEARS algorithm versus Wells’ score: Predictive accuracies in pulmonary embolism based on the gold standard CT pulmonary angiography. Crit Care Med. 2020 May;48(5):704-8. doi: 10.1097/CCM.0000000000004271.
  • Bratseth V, Byrkjeland R, Njerve IU, Solheim S, Arnesen H, Seljeflot I. Procoagulant activity in patients with combined type 2 diabetes and coronary artery disease: No effects of long-term exercise training. Diab Vasc Dis Res. 2017 Mar;14(2):144-51. doi: 10.1177/1479164116679080.
  • Aggarwal A, Srivastava S, Velmurugan M. Newer perspectives of coronary artery disease in young. World J Cardiol. 2016 Dec 26;8(12):728-34. doi: 10.4330/wjc.v8.i12.728.
  • Prucha M, Bellingan G, Zazula R. Sepsis biomarkers. Clin Chim Acta. 2015 Feb 2;440:97-103. doi: 10.1016/j.cca.2014.11.012.
  • Kudo D, Goto T, Uchimido R, Hayakawa M, Yamakawa K, Abe T, Shiraishi A, Kushimoto S. Coagulation phenotypes in sepsis and effects of recombinant human thrombomodulin: an analysis of three multicentre observational studies. Crit Care. 2021 Mar 19; 25(1):114. doi: 10.1186/s13054-021-03541-5.
  • Saenz-Pipaon G, Martinez-Aguilar E, Orbe J, González Miqueo A, Fernandez-Alonso L, Paramo JA, Roncal C. The role of circulating biomarkers in peripheral arterial disease. Int J Mol Sci. 2021 Mar 30;22(7):3601. doi: 10.3390/ijms22073601.
  • Khalil J, Bensaid B, Elkacemi H, Afif M, Bensaid Y, Kebdani T, Benjaafar N. Venous thromboembolism in cancer patients: an underestimated major health problem. World J Surg Oncol. 2015 Jun 20;13:204. doi: 10.1186/s12957-015-0592-8.
  • Sulli A, Gotelli E, Casabella A, Paolino S, Pizzorni C, Alessandri E, Grosso M, Ferone D, Smith V, Cutolo M. Vitamin D and lung outcomes in elderly COVID-19 patients. Nutrients. 2021 Feb 24;13(3):717. doi: 10.3390/nu13030717.
  • Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5.
  • Gungor B, Atici A, Baycan OF, Alici G, Ozturk F, Tugrul S, Asoglu R, Cevik E, Sahin I, Barman HA. . Elevated D-dimer levels on admission are associated with severity and increased risk of mortality in COVID-19: A systematic review and meta-analysis. Am J Emerg Med. 2021 Jan;39:173-9. doi: 10.1016/j.ajem.2020.09.018.
  • Lin Y, Liu Z, Qiu Y, Zhang J, Wu H, Liang R, Chen G, Qin G, Li Y, Zou D. Clinical significance of plasma D-dimer and fibrinogen in digestive cancer: A systematic review and meta-analysis. Eur J Surg Oncol. 2018 Oct;44(10):1494-503. doi: 10.1016/j.ejso.2018.07.052.

Retrospective Analysis of Follow-up and Results of Patients with High D-Dimer Value and Discharged without Emergency Pathology

Year 2023, Volume: 5 Issue: 2, 135 - 140, 29.04.2023
https://doi.org/10.46310/tjim.1169467

Abstract

Background This study aimed to retrospectively examine the morbidity and mortality rates after discharge of patients who applied to the emergency department with high D-dimer values but had no pathology upon evaluation.
Material and Methods Patients over the age of 18 who applied to Bursa Uludağ University Faculty of Medicine Emergency Department with preliminary diagnosis of pulmonary embolism in a two-year period between January 2018 and December 2019 were included in the study. The patient group consisted of cases with high D-dimer levels while the control group inluded patients with negative D-dimer and no pathology on discharge.
Results A total of 594 cases; 297 D-dimer positive (+) and 297 D-dimer negative (-), were included in the study. A significant difference existed between the percentage of patients developing illness post-discharge in the D-dimer (+) 18.86% (n=56) and D-dimer (-) 1.68% (n=5) groups, respectively. The most common illness identified in the dimer (+) group after discharge up was pneumonia (n=11), followed by Coronary Artery Disease (n=5). Death rate was 1.68% (n=5) in the D-dimer (-) group and 11.78% (n=35) in the D-dimer (+) group; a statistically significant difference (p=0.001).
Conclusions In conclusion, both morbidity and mortality rates were found to be significantly higher in the D-dimer positive group.

References

  • Robert-Ebadi H, Righini M. D-dimer: Well beyond diagnosis! J Med Vasc. 2020 Sep;45(5):239-40. doi: 10.1016/j.jdmv.2020.06.006.
  • Lim W, Le Gal G, Bates SM, Righini M, Haramati LB, Lang E, Kline JA, Chasteen S, Snyder M, Patel P, Bhatt M, Patel P, Braun C, Begum H, Wiercioch W, Schünemann HJ, Mustafa RA. American Society of Hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism. Blood Adv. 2018 Nov 27;2(22):3226-56. doi: 10.1182/bloodadvances.2018024828.
  • Iwuji K, Almekdash H, Nugent KM, Islam E, Hyde B, Kopel J, Opiegbe A, Appiah D. Age-adjusted D-dimer in the prediction of pulmonary embolism: Systematic review and meta-analysis. J Prim Care Community Health. 2021 Jan-Dec;12:21501327211054996. doi: 10.1177/21501327211054996.
  • Crawford F, Andras A, Welch K, Sheares K, Keeling D, Chappell FM. D-dimer test for excluding the diagnosis of pulmonary embolism. Cochrane Database Syst Rev. 2016 Aug 5;2016(8):CD010864. doi: 10.1002/14651858.CD010864.pub2.
  • Senior K, Burles K, Wang D, Grigat D, Innes GD, Andruchow JE, Lang ES, McRae AD. Age-adjusted D-dimer thresholds in the investigation of suspected pulmonary embolism: A retrospective evaluation in patients ages 50 and older using administrative data. CJEM. 2018 Sep;20(5):725-31. doi: 10.1017/cem.2018.389.
  • Turak O, Canpolat U, Ozcan F, Yayla C, Mendi MA, Oksüz F, Tok D, Tok D, Cağlı K, Gölbaşı Z. D-dimer level predicts in-hospital mortality in patients with infective endocarditis: a prospective single-centre study. Thromb Res. 2014 Sep;134(3):587-92. doi: 10.1016/j.thromres.2014.06.015.
  • Mélé N, Turc G. Stroke associated with recent mycoplasma pneumoniae infection: A systematic review of clinical features and presumed pathophysiological mechanisms. Front Neurol. 2018 Dec 21;9:1109. doi: 10.3389/fneur.2018.01109.
  • Yao J, Bai T, Yang B, Sun L. The diagnostic value of D-dimer in acute aortic dissection: a meta-analysis. J Cardiothorac Surg. 2021 Nov 27;16(1):343. doi: 10.1186/s13019-021-01726-1.
  • Sakka M, Connors JM, Hékimian G, Martin-Toutain I, Crichi B, Colmegna I, Bonnefont-Rousselot D, Farge D, Frere C. Association between D-Dimer levels and mortality in patients with coronavirus disease 2019 (COVID-19): a systematic review and pooled analysis. J Med Vasc. 2020 Sep;45(5):268-74. doi: 10.1016/j.jdmv.2020.05.003.
  • Yang C, Zeng HH, Huang J, Zhang QY, Lin K. Predictive roles of D-dimer for mortality of patients with community-acquired pneumonia: a systematic review and meta-analysis. J Bras Pneumol. 2021 Dec 15;47(6):e20210072. doi: 10.36416/1806-3756/e20210072.
  • Rodelo JR, De la Rosa G, Valencia ML, Ospina S, Arango CM, Gómez CI, García A, Nuñez E, Jaimes FA. D-dimer is a significant prognostic factor in patients with suspected infection and sepsis. Am J Emerg Med. 2012 Nov;30(9):1991-9. doi: 10.1016/j.ajem.2012.04.033.
  • Li J, Wang Y, Li J, Che G. Prognostic value of pretreatment D-Dimer level in small-cell lung cancer: A meta-analysis. Technol Cancer Res Treat. 2021 Jan-Dec;20:1533033821989822. doi: 10.1177/1533033821989822.
  • Abdelaal Ahmed Mahmoud M Alkhatip A, Donnelly M, Snyman L, Conroy P, Hamza MK, Murphy I, Purcell A, McGuire D. YEARS algorithm versus Wells’ score: Predictive accuracies in pulmonary embolism based on the gold standard CT pulmonary angiography. Crit Care Med. 2020 May;48(5):704-8. doi: 10.1097/CCM.0000000000004271.
  • Bratseth V, Byrkjeland R, Njerve IU, Solheim S, Arnesen H, Seljeflot I. Procoagulant activity in patients with combined type 2 diabetes and coronary artery disease: No effects of long-term exercise training. Diab Vasc Dis Res. 2017 Mar;14(2):144-51. doi: 10.1177/1479164116679080.
  • Aggarwal A, Srivastava S, Velmurugan M. Newer perspectives of coronary artery disease in young. World J Cardiol. 2016 Dec 26;8(12):728-34. doi: 10.4330/wjc.v8.i12.728.
  • Prucha M, Bellingan G, Zazula R. Sepsis biomarkers. Clin Chim Acta. 2015 Feb 2;440:97-103. doi: 10.1016/j.cca.2014.11.012.
  • Kudo D, Goto T, Uchimido R, Hayakawa M, Yamakawa K, Abe T, Shiraishi A, Kushimoto S. Coagulation phenotypes in sepsis and effects of recombinant human thrombomodulin: an analysis of three multicentre observational studies. Crit Care. 2021 Mar 19; 25(1):114. doi: 10.1186/s13054-021-03541-5.
  • Saenz-Pipaon G, Martinez-Aguilar E, Orbe J, González Miqueo A, Fernandez-Alonso L, Paramo JA, Roncal C. The role of circulating biomarkers in peripheral arterial disease. Int J Mol Sci. 2021 Mar 30;22(7):3601. doi: 10.3390/ijms22073601.
  • Khalil J, Bensaid B, Elkacemi H, Afif M, Bensaid Y, Kebdani T, Benjaafar N. Venous thromboembolism in cancer patients: an underestimated major health problem. World J Surg Oncol. 2015 Jun 20;13:204. doi: 10.1186/s12957-015-0592-8.
  • Sulli A, Gotelli E, Casabella A, Paolino S, Pizzorni C, Alessandri E, Grosso M, Ferone D, Smith V, Cutolo M. Vitamin D and lung outcomes in elderly COVID-19 patients. Nutrients. 2021 Feb 24;13(3):717. doi: 10.3390/nu13030717.
  • Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5.
  • Gungor B, Atici A, Baycan OF, Alici G, Ozturk F, Tugrul S, Asoglu R, Cevik E, Sahin I, Barman HA. . Elevated D-dimer levels on admission are associated with severity and increased risk of mortality in COVID-19: A systematic review and meta-analysis. Am J Emerg Med. 2021 Jan;39:173-9. doi: 10.1016/j.ajem.2020.09.018.
  • Lin Y, Liu Z, Qiu Y, Zhang J, Wu H, Liang R, Chen G, Qin G, Li Y, Zou D. Clinical significance of plasma D-dimer and fibrinogen in digestive cancer: A systematic review and meta-analysis. Eur J Surg Oncol. 2018 Oct;44(10):1494-503. doi: 10.1016/j.ejso.2018.07.052.
There are 23 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Original Articles
Authors

Fulya Büşra Kaval This is me 0000-0001-9964-0945

Halil İbrahim Çıkrıklar 0000-0002-8073-6207

Vahide Aslıhan Durak 0000-0003-0836-7862

Issa Omar 0000-0002-6665-7166

Burak Kurtoğlu 0000-0001-7788-915X

Erol Armagan 0000-0002-4641-9873

Publication Date April 29, 2023
Submission Date September 1, 2022
Acceptance Date September 25, 2022
Published in Issue Year 2023 Volume: 5 Issue: 2

Cite

EndNote Kaval FB, Çıkrıklar Hİ, Durak VA, Omar I, Kurtoğlu B, Armagan E (April 1, 2023) Retrospective Analysis of Follow-up and Results of Patients with High D-Dimer Value and Discharged without Emergency Pathology. Turkish Journal of Internal Medicine 5 2 135–140.

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