Research Article
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Year 2023, Volume: 5 Issue: 2, 77 - 83, 29.04.2023
https://doi.org/10.46310/tjim.1210699

Abstract

References

  • NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA. 1993 Jul 7;270(1):83-90.
  • Akkus E, Kadioglu A, Esen A, Doran S, Ergen A, Anafarta K, Hattat H; Turkish Erectile Dysfunction Prevalence Study Group. Prevalence and correlates of erectile dysfunction in Turkey: a population-based study. Eur Urol. 2002 Mar;41(3):298-304. doi: 10.1016/s0302-2838(02)00027-1.
  • DeLay KJ, Haney N, Hellstrom WJ. Modifying risk factors in the management of erectile dysfunction: A review. World J Mens Health. 2016 Aug;34(2):89-100. doi: 10.5534/wjmh.2016.34.2.89.
  • Shamloul R, Ghanem H. Erectile dysfunction. Lancet. 2013 Jan 12;381(9861):153-65. doi: 10.1016/S0140-6736(12)60520-0.
  • Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, Wittchen HU, Kendler KS. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994 Jan;51(1):8-19. doi: 10.1001/archpsyc.1994.03950010008002.
  • Shiri R, Koskimäki J, Tammela TL, Häkkinen J, Auvinen A, Hakama M. Bidirectional relationship between depression and erectile dysfunction. J Urol. 2007 Feb;177(2):669-73. doi: 10.1016/j.juro.2006.09.030.
  • Nangalia J, Smith H, Wimperis JZ. Isolated neutropenia during ABVD chemotherapy for Hodgkin lymphoma does not require growth factor support. Leuk Lymphoma. 2008 Aug;49(8):1530-6. doi: 10.1080/10428190802210718.
  • Flinn IW, van der Jagt R, Kahl BS, Wood P, Hawkins TE, Macdonald D, Hertzberg M, Kwan YL, Simpson D, Craig M, Kolibaba K, Issa S, Clementi R, Hallman DM, Munteanu M, Chen L, Burke JM. Randomized trial of bendamustine-rituximab or R-CHOP/R-CVP in first-line treatment of indolent NHL or MCL: the BRIGHT study. Blood. 2014 May 8;123(19):2944-52. doi: 10.1182/blood-2013-11-531327.
  • Ricci E, Parazzini F, Mirone V, Imbimbo C, Palmieri A, Bortolotti A, Di Cintio E, Landoni M, Lavezzari M. Current drug use as risk factor for erectile dysfunction: results from an Italian epidemiological study. Int J Impot Res. 2003 Jun;15(3):221-4. doi: 10.1038/sj.ijir.3901008.
  • Brændengen M, Tveit KM, Bruheim K, Cvancarova M, Berglund Å, Glimelius B. Late patient-reported toxicity after preoperative radiotherapy or chemoradiotherapy in nonresectable rectal cancer: results from a randomized Phase III study. Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):1017-24. doi: 10.1016/j.ijrobp.2010.07.007.
  • Dean RC, Lue TF. Physiology of penile erection and pathophysology of erectile dysfunction. Urol Clin North Am. 2005 Nov;32(4):379-95, v. doi: 10.1016/j.ucl.2005.08.007.
  • Peltier A, van Velthoven R, Roumeguère T. Current mamagement of erectile dysfunction after cancer treatment. Curr Opin Oncol. 2009 Jul;21(4):303-9. doi: 10.1097/CCO.0b013e32832b9d76.
  • Chatterjee R, Andrews HO, McGarrigle HH, Kottaridis PD, Lees WR, Mackinnon S, Ralph DJ, Goldstone AH. Cavernosal arterial insufficiency is a major component of erectile dysfunction in some recipients of high-dose chemotherapy/chemo-radiotherapy for haematological malignancies. Bone Marrow Transplant. 2000 Jun;25(11):1185-9. doi: 10.1038/sj.bmt.1702391.
  • Zhang MF, Wen YS, Liu WY, Peng LF, Wu XD, Liu QW. Effectiveness of mindfulness-based therapy for reducing anxiety and depression in patients with cancer: A meta-analysis. Medicine (Baltimore). 2015 Nov;94(45):e0897-0. doi: 10.1097/MD.0000000000000897.
  • Kornblith AB, Herndon JE 2nd, Zuckerman E, Cella DF, Cherin E, Wolchok S, Weiss RB, Diehl LF, Henderson E, Cooper MR, Schiffer C, Canellos GP, Mayer RJ, Silver RT, Schilling A, Peterson BA, Greenberg D, Holland JC. Comparison of psychosocial adaptation of advanced stage Hodgkin's disease and acute leukemia survivors. Cancer and Leukemia Group B. Ann Oncol. 1998 Mar;9(3):297-306. doi: 10.1023/a:1008297130258.
  • Fobair P, Hoppe RT, Bloom J, Cox R, Varghese A, Spiegel D. Psychosocial problems among survivors of Hodgkin's disease. J Clin Oncol. 1986 May;4(5):805-14. doi: 10.1200/JCO.1986.4.5.805.
  • Galbraith ME, Crighton F. Alterations of sexual function in men with cancer. Semin Oncol Nurs. 2008 May;24(2):102-14. doi: 10.1016/j.soncn.2008.02.010.
  • Syrjala KL, Kurland BF, Abrams JR, Sanders JE, Heiman JR. Sexual function changes during the 5 years after high-dose treatment and hematopoietic cell transplantation for malignancy, with case-matched controls at 5 years. Blood. 2008 Feb 1;111(3):989-96. doi: 10.1182/blood-2007-06-096594.
  • Puscheck E, Philip PA, Jeyendran RS. Male fertility preservation and cancer treatment. Cancer Treat Rev. 2004 Apr;30(2):173-80. doi: 10.1016/j.ctrv.2003.07.005.
  • Howell SJ, Radford JA, Smets EM, Shalet SM. Fatigue, sexual function and mood following treatment for haematological malignancy: the impact of mild Leydig cell dysfunction. Br J Cancer. 2000 Feb;82(4):789-93. doi: 10.1054/bjoc.1999.1000.
  • Rajfer J. Relationship between testosterone and erectile dysfunction. Rev Urol. 2000 Spring;2(2):122-8.

What is the main reason of erectile dysfunction in lymphoma patients: Chemotherapy or Depression?

Year 2023, Volume: 5 Issue: 2, 77 - 83, 29.04.2023
https://doi.org/10.46310/tjim.1210699

Abstract

Background Erectile dysfunction (ED) may be associated with chemotherapy and depression in lymphoma patients. The role of depression in developing ED in lymphoma patients may be more critical than chemotherapy. This study aimed to determine which plays a more important role in ED.
Material and Methods This study included 20 patients aged under 60 years who were admitted to the Hematology Outpatient Clinic between March 2015 and March 2016 and diagnosed with lymphoma. While the Beck Depression Inventory (BDI) was used to assess depression severity before (T1), during (T2) and after (T3) chemotherapy, the International Index of Erectile Function (IIEF) was used to assess sexual function. The Mann-Whitney U and Wilcoxon signed-rank tests were used for statistical analysis. A p-value of <0.05 was considered statistically significant.
Results Twenty male lymphoma patients (14 [70%] patients with non-Hodgkin lymphoma and 6 [30%] patients with Hodgkin lymphoma) were included in the study. The mean BDI score was 11.75±1.44 at T1, 6.60±3.61 at T2, and 3.25±2.12 at T3, respectively (p<0.01). The mean IIEF score was 15.25±6.12 at T1, 12.95±6.03 at T2, and 20.40±8.59 at T3, respectively (p<0.01). There was a significant decrease in the mean BDI and IIEF scores between T1 and T2. However, the mean BDI score decreased between T2 and T3, while the mean IIEF score tended to increase.
Conclusions It is impossible to suggest a single cause when considering the multifactorial aetiology of ED in lymphoma patients. However, our study showed that depression and related psychological factors are the leading cause of ED in lymphoma patients.

References

  • NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA. 1993 Jul 7;270(1):83-90.
  • Akkus E, Kadioglu A, Esen A, Doran S, Ergen A, Anafarta K, Hattat H; Turkish Erectile Dysfunction Prevalence Study Group. Prevalence and correlates of erectile dysfunction in Turkey: a population-based study. Eur Urol. 2002 Mar;41(3):298-304. doi: 10.1016/s0302-2838(02)00027-1.
  • DeLay KJ, Haney N, Hellstrom WJ. Modifying risk factors in the management of erectile dysfunction: A review. World J Mens Health. 2016 Aug;34(2):89-100. doi: 10.5534/wjmh.2016.34.2.89.
  • Shamloul R, Ghanem H. Erectile dysfunction. Lancet. 2013 Jan 12;381(9861):153-65. doi: 10.1016/S0140-6736(12)60520-0.
  • Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, Wittchen HU, Kendler KS. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry. 1994 Jan;51(1):8-19. doi: 10.1001/archpsyc.1994.03950010008002.
  • Shiri R, Koskimäki J, Tammela TL, Häkkinen J, Auvinen A, Hakama M. Bidirectional relationship between depression and erectile dysfunction. J Urol. 2007 Feb;177(2):669-73. doi: 10.1016/j.juro.2006.09.030.
  • Nangalia J, Smith H, Wimperis JZ. Isolated neutropenia during ABVD chemotherapy for Hodgkin lymphoma does not require growth factor support. Leuk Lymphoma. 2008 Aug;49(8):1530-6. doi: 10.1080/10428190802210718.
  • Flinn IW, van der Jagt R, Kahl BS, Wood P, Hawkins TE, Macdonald D, Hertzberg M, Kwan YL, Simpson D, Craig M, Kolibaba K, Issa S, Clementi R, Hallman DM, Munteanu M, Chen L, Burke JM. Randomized trial of bendamustine-rituximab or R-CHOP/R-CVP in first-line treatment of indolent NHL or MCL: the BRIGHT study. Blood. 2014 May 8;123(19):2944-52. doi: 10.1182/blood-2013-11-531327.
  • Ricci E, Parazzini F, Mirone V, Imbimbo C, Palmieri A, Bortolotti A, Di Cintio E, Landoni M, Lavezzari M. Current drug use as risk factor for erectile dysfunction: results from an Italian epidemiological study. Int J Impot Res. 2003 Jun;15(3):221-4. doi: 10.1038/sj.ijir.3901008.
  • Brændengen M, Tveit KM, Bruheim K, Cvancarova M, Berglund Å, Glimelius B. Late patient-reported toxicity after preoperative radiotherapy or chemoradiotherapy in nonresectable rectal cancer: results from a randomized Phase III study. Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):1017-24. doi: 10.1016/j.ijrobp.2010.07.007.
  • Dean RC, Lue TF. Physiology of penile erection and pathophysology of erectile dysfunction. Urol Clin North Am. 2005 Nov;32(4):379-95, v. doi: 10.1016/j.ucl.2005.08.007.
  • Peltier A, van Velthoven R, Roumeguère T. Current mamagement of erectile dysfunction after cancer treatment. Curr Opin Oncol. 2009 Jul;21(4):303-9. doi: 10.1097/CCO.0b013e32832b9d76.
  • Chatterjee R, Andrews HO, McGarrigle HH, Kottaridis PD, Lees WR, Mackinnon S, Ralph DJ, Goldstone AH. Cavernosal arterial insufficiency is a major component of erectile dysfunction in some recipients of high-dose chemotherapy/chemo-radiotherapy for haematological malignancies. Bone Marrow Transplant. 2000 Jun;25(11):1185-9. doi: 10.1038/sj.bmt.1702391.
  • Zhang MF, Wen YS, Liu WY, Peng LF, Wu XD, Liu QW. Effectiveness of mindfulness-based therapy for reducing anxiety and depression in patients with cancer: A meta-analysis. Medicine (Baltimore). 2015 Nov;94(45):e0897-0. doi: 10.1097/MD.0000000000000897.
  • Kornblith AB, Herndon JE 2nd, Zuckerman E, Cella DF, Cherin E, Wolchok S, Weiss RB, Diehl LF, Henderson E, Cooper MR, Schiffer C, Canellos GP, Mayer RJ, Silver RT, Schilling A, Peterson BA, Greenberg D, Holland JC. Comparison of psychosocial adaptation of advanced stage Hodgkin's disease and acute leukemia survivors. Cancer and Leukemia Group B. Ann Oncol. 1998 Mar;9(3):297-306. doi: 10.1023/a:1008297130258.
  • Fobair P, Hoppe RT, Bloom J, Cox R, Varghese A, Spiegel D. Psychosocial problems among survivors of Hodgkin's disease. J Clin Oncol. 1986 May;4(5):805-14. doi: 10.1200/JCO.1986.4.5.805.
  • Galbraith ME, Crighton F. Alterations of sexual function in men with cancer. Semin Oncol Nurs. 2008 May;24(2):102-14. doi: 10.1016/j.soncn.2008.02.010.
  • Syrjala KL, Kurland BF, Abrams JR, Sanders JE, Heiman JR. Sexual function changes during the 5 years after high-dose treatment and hematopoietic cell transplantation for malignancy, with case-matched controls at 5 years. Blood. 2008 Feb 1;111(3):989-96. doi: 10.1182/blood-2007-06-096594.
  • Puscheck E, Philip PA, Jeyendran RS. Male fertility preservation and cancer treatment. Cancer Treat Rev. 2004 Apr;30(2):173-80. doi: 10.1016/j.ctrv.2003.07.005.
  • Howell SJ, Radford JA, Smets EM, Shalet SM. Fatigue, sexual function and mood following treatment for haematological malignancy: the impact of mild Leydig cell dysfunction. Br J Cancer. 2000 Feb;82(4):789-93. doi: 10.1054/bjoc.1999.1000.
  • Rajfer J. Relationship between testosterone and erectile dysfunction. Rev Urol. 2000 Spring;2(2):122-8.
There are 21 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Original Articles
Authors

Cumali Yalçın 0000-0002-5129-2977

Aslan Erdoğan This is me 0000-0002-1094-5572

Güven Yılmaz 0000-0001-9972-2537

Publication Date April 29, 2023
Submission Date November 30, 2022
Acceptance Date March 15, 2023
Published in Issue Year 2023 Volume: 5 Issue: 2

Cite

EndNote Yalçın C, Erdoğan A, Yılmaz G (April 1, 2023) What is the main reason of erectile dysfunction in lymphoma patients: Chemotherapy or Depression?. Turkish Journal of Internal Medicine 5 2 77–83.

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