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Evaluation of the Relationship Between Papillary Thyroid Cancer and Radiation Exposure

Year 2024, Volume: 6 Issue: 1, 7 - 11, 29.01.2024
https://doi.org/10.46310/tjim.1255695

Abstract

Introduction: It has been identified ionizing radiation as the definitive cause of cancer in humans. One third of the tumors that develop after radiation exposure are malignant, with papillary thyroid cancer (PTC) being the most common cancer type. This study aimed to investigate the relationship between total radiation dose (TRD) received during imaging tests and thyroid cancer occurrence in patients diagnosed with PTC.
Material and Method: The study was designed to retrospectively review the data of adult patients aged ≥ 18 years who were diagnosed with PTC between 2005 and 2022. Patients diagnosed with a condition other than PTC were excluded from the study
Result: 307 patients with papillary thyroid cancer were 256 (83.4%) women, with a mean age of 44.7 ± 13.5 years. A statistically significant relationship was observed between TRD and multifocality (p = 0.02). Tumor size (r = 0,2, p = 0.07) weakly correlated with TRD. And TRD (OR: 0.9, 95% CI: 1.0-1.1, p: 0.006) according to multifocalty were found to be significant.
Discussion: This study found an association between TRD taken during imaging tests and multifocality. As a result, the authors aimed to remind clinicians that the disease may progress more aggressively and that thyroid cancer may develop in patients exposed to radiation as a result of excessive imaging tests

Project Number

yoktur

References

  • Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA. 2006;295:2164–7.
  • Ito Y, Nikiforov YE, Schlumberger M, Vigneri R. Increasing incidence of thyroid cancer: controversies explored. Nat Rev Endocrinol. 2013;9:178–84.
  • Zhu C, Zheng T, Kilfoy BA, et al. A birth cohort analysis of the incidence of papillary thyroid cancer in the United States, 1973–2004. Thyroid. 2009;19:1061–6
  • IARC. IARC Monograph Volume 100D: A review of human carcinogens—radiation. Lyon, France: 2012. Monographs on the Evaluation of Carcinogenic Risks to Humans.
  • Ron E, Lubin JH, Shore RE, Mabuchi K, Modan B, Pottern LM, et al. Thyroid cancer afterexposure to external radiation: a pooled analysis of seven studies. 1995. Radiat Res.2012;178(2):AV43-60.
  • Schneider AB, Ron E, Lubin J, Stovall M, Gierlowski TC. Dose-response relationships for radiation-induced thyroid cancer and thyroid nodules: evidence for the prolonged effects of radiation on the thyroid. J Clin Endocrinol Metab. 1993 Aug;77(2):362-9. doi: 10.1210/jcem.77.2.8345040. PMID: 8345040.
  • Iglesias, M. L., Schmidt, A., Ghuzlan, A. A., Lacroix, L., Vathaire, F. D., Chevillard, S., & Schlumberger, M. (2017). Radiation exposure and thyroid cancer: a review. Archives of endocrinology and metabolism, 61, 180-187.
  • Türk Radyasyon Onkolojisi Derneği. Görüntüleme Teknikleri - Radyasyon Dozu. (2022). Acsess Date: 23 May 2022. https://www.trod.org.tr/app_society_patient?id=14
  • Casella C, Fusco M. Thyroid cancer. Epidemiol Prev. 2004 Mar-Apr;28(2 Suppl):88-91
  • Veiga LHS, Holmberg E, Anderson H, Pottern L, Sadetzki S, Adams MJ, et al. Thyroid cancerafter childhood exposure to external radiation: an updated pooled analysis of 12 studies. RadiatRes. 2016;185(5):473-84.
  • Boice JD. Thyroid disease 60 years after Hiroshima and 20 years after Chernobyl. JAMA.2006;295(9):1060-2.
  • DeLellis, R. A. (Ed.). (2004). Pathology and genetics of tumours of endocrine organs (Vol. 8). IARC.
  • Harach, H. R., Franssila, K. O., & Wasenius, V. M. (1985). Occult papillary carcinoma of the thyroid. A “normal” finding in Finland. A systematic autopsy study. Cancer, 56(3), 531-538.
  • Seaberg, R. M., Eski, S., & Freeman, J. L. (2009). Influence of previous radiation exposure on pathologic features and clinical outcome in patients with thyroid cancer. Archives of
Year 2024, Volume: 6 Issue: 1, 7 - 11, 29.01.2024
https://doi.org/10.46310/tjim.1255695

Abstract

Supporting Institution

yoktur

Project Number

yoktur

References

  • Davies L, Welch HG. Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA. 2006;295:2164–7.
  • Ito Y, Nikiforov YE, Schlumberger M, Vigneri R. Increasing incidence of thyroid cancer: controversies explored. Nat Rev Endocrinol. 2013;9:178–84.
  • Zhu C, Zheng T, Kilfoy BA, et al. A birth cohort analysis of the incidence of papillary thyroid cancer in the United States, 1973–2004. Thyroid. 2009;19:1061–6
  • IARC. IARC Monograph Volume 100D: A review of human carcinogens—radiation. Lyon, France: 2012. Monographs on the Evaluation of Carcinogenic Risks to Humans.
  • Ron E, Lubin JH, Shore RE, Mabuchi K, Modan B, Pottern LM, et al. Thyroid cancer afterexposure to external radiation: a pooled analysis of seven studies. 1995. Radiat Res.2012;178(2):AV43-60.
  • Schneider AB, Ron E, Lubin J, Stovall M, Gierlowski TC. Dose-response relationships for radiation-induced thyroid cancer and thyroid nodules: evidence for the prolonged effects of radiation on the thyroid. J Clin Endocrinol Metab. 1993 Aug;77(2):362-9. doi: 10.1210/jcem.77.2.8345040. PMID: 8345040.
  • Iglesias, M. L., Schmidt, A., Ghuzlan, A. A., Lacroix, L., Vathaire, F. D., Chevillard, S., & Schlumberger, M. (2017). Radiation exposure and thyroid cancer: a review. Archives of endocrinology and metabolism, 61, 180-187.
  • Türk Radyasyon Onkolojisi Derneği. Görüntüleme Teknikleri - Radyasyon Dozu. (2022). Acsess Date: 23 May 2022. https://www.trod.org.tr/app_society_patient?id=14
  • Casella C, Fusco M. Thyroid cancer. Epidemiol Prev. 2004 Mar-Apr;28(2 Suppl):88-91
  • Veiga LHS, Holmberg E, Anderson H, Pottern L, Sadetzki S, Adams MJ, et al. Thyroid cancerafter childhood exposure to external radiation: an updated pooled analysis of 12 studies. RadiatRes. 2016;185(5):473-84.
  • Boice JD. Thyroid disease 60 years after Hiroshima and 20 years after Chernobyl. JAMA.2006;295(9):1060-2.
  • DeLellis, R. A. (Ed.). (2004). Pathology and genetics of tumours of endocrine organs (Vol. 8). IARC.
  • Harach, H. R., Franssila, K. O., & Wasenius, V. M. (1985). Occult papillary carcinoma of the thyroid. A “normal” finding in Finland. A systematic autopsy study. Cancer, 56(3), 531-538.
  • Seaberg, R. M., Eski, S., & Freeman, J. L. (2009). Influence of previous radiation exposure on pathologic features and clinical outcome in patients with thyroid cancer. Archives of
There are 14 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Original Articles
Authors

Deniz Gezer 0000-0002-9036-0135

Seval Müzeyyen Ecin 0000-0002-7701-7826

Project Number yoktur
Publication Date January 29, 2024
Submission Date February 24, 2023
Acceptance Date July 11, 2023
Published in Issue Year 2024 Volume: 6 Issue: 1

Cite

EndNote Gezer D, Ecin SM (January 1, 2024) Evaluation of the Relationship Between Papillary Thyroid Cancer and Radiation Exposure. Turkish Journal of Internal Medicine 6 1 7–11.

e-ISSN: 2687-4245 

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