Renal disorders occurring in Behçet’s disease

Year 2025, Volume: 7 Issue: 3, 87 - 89, 29.07.2025

Vitorino Modesto Dos Santos , Kin Modesto Sugai Rafael Campos Nunes

https://doi.org/10.46310/tjim.1656029

Abstract

Behçet disease is prevalent in men during the third decade of life, and renal, neurological, gastrointestinal, cardiac, and pulmonary changes are less common. Renal disorders include artery stenosis, renal venous thrombosis, hematuria, proteinuria, glomerulonephritis, amyloidosis, renovascular hypertension, and end-stage renal disease. More rarely, Behçet disease may be coexistent with IgA nephropathy and arterial hypertension in pediatric cases. The aim is to comment on novel literature data highlighting an article published in this journal to enhance suspicion index for early diagnosis and prompt intervention, and organ-specific treatments for conditions presenting multisystem involvement to reduce morbimortality.

Keywords

Aneurysm; Behçet’s disease; Renal; Treatment

Ethical Statement

None

References

• Yagiz B, Coskun BN, Cakan ZK, Gunduz GU, Yalcinbayir O, Serkan Yazici S, Saricaoglu H, Dalkilic E, Pehlivan Y. Biological agent use in Behcet’s patients who are resistant to conventional treatments: a multidisciplinary retrospective study. Turk J Int Med. 2023 Jan 29;5(1):33-40. doi: 10.46310/tjim.1144532.
• Boustani S, El Idrissi E, Elkaddouri O, Elkourchi M, Wakrim S, Bouissar W. Spontaneous renal hematoma as a rare vascular manifestation of Behçet’s disease: a case report. Egypt J Intern Med. 2025 Feb 13;37:33. doi: 10.1186/s43162-025-00418-9.
• Fernandes BM, Garcia S, Rato M, Pinheiro F, Pimenta S, Mariz E, Neto R, Canão PA, Silva R, Bernardes M, Costa L. Renal involvement in Behçet´s Disease: a rare clinical challenge. ARP Rheumatol. 2022 Apr-Jun;1(2):174-6.
• Hegazy MT, Fayed A, Nuzzolese R, Sota J, Ragab G. Autoinflammatory diseases and the kidney. Immunol Res. 2023 Aug;71(4):578-7. doi: 10.1007/s12026-023-09375-3.
• Kinguchi S, Tamura M, Furuta R, Toyota K, Ishiga K, Kanaoka T, Azushima K, Wakui H, Hirawa N, Tamura K. Behçet’s disease presenting as malignant hypertension induced by renovascular hypertension. CEN Case Rep. 2024 Jul 30. doi: 10.1007/s13730-024-00918-7.
• Liao Y, Hong Q, Wang Y, Su F, Gan C, Hu J. A patient with Behcet’s disease and IgA nephropathy in China. BMC Nephrol. 2024 Sep 18;25(1):310. doi: 10.1186/s12882-024-03748-y.
• Wang X, Zhou Z, Li J, Su G, Li X. Hypertension as a prominent manifestation secondary to renal artery lesions in pediatric Behcet’s disease. Pediatr Rheumatol Online J. 2024 Jan19;22(1):19. doi: 10.1186/s12969-023-00932-6.
• Watanabe-Kusunoki K, Kato M, Oki Y, Shimizu T, Kusunoki Y, Furukawa S, Furukawa S, Kitakawa H, Sakai K. Parallel disease activity of Behçet’s disease with renal and entero involvements: a case report. BMC Nephrol. 2021 Apr 7;22(1):122. doi: 10.1186/s12882-021-02327-9.