Unveiling Multiple Endocrine Neoplasia Type 1 (MEN-1) in a Young Pakistani Male with Recurrent Hypoglycemia: A Diagnostic Odyssey in a Resource-Limited Setting

Year 2025, Volume: 7 Issue: 4, 141 - 146, 29.10.2025

Zoha Rehman , Dr. Noshaba Razaq Dr. Wajahat Sultan Baig , Amara Anees Zunaira Abbas Zavata Afnan Hamna Khalid Hamna Nasir

Abstract

This case report describes a 32-year-old Pakistani male who was initially admitted to a tertiary care hospital with Typhoid fever, but later developed recurrent life-threatening hypoglycemia. Extensive investigations revealed elevated insulin and C-peptide levels, a pituitary microadenoma, and a somatostatin-avid gastric lesion, leading to the diagnosis of Multiple Endocrine Neoplasia type 1 (MEN-1). Management included dextrose infusions, somatostatin-analogue therapy, and supportive care. The case highlights the diagnostic challenges of MEN-1 in atypical presentations and resource-limited settings, underscoring the need for a multidisciplinary approach to treatment and psychosocial support.

Keywords

MEN-1 Syndrome , Insulinoma , Pituitary Adenoma , Hypoglycemia

Ethical Statement

THIS RESEARCH HAS BEEN CONDUCTED WITH PROPER SIGNED INFORMED CONSENT AND CONSIDERING ALL ETHICAL ASPECTS OF A RESEARCH WORK.

Supporting Institution

WAH MEDICAL COLLEGE , POF HOSPITAL , WAHCANTT

Project Number

not applicable

Thanks

THANKS .

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