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Rejeneratif Tıpta Kullanılan Organ ve Doku Deselülerizasyon Yöntemleri

Year 2016, Volume: 1 Issue: 2, 96 - 102, 29.12.2016

Abstract

Doku mühendisliği ve rejeneratif tıbbın amacı hasar gören vücut bölgelerinde doku ve organların yeniden yapılandırılmasıdır. Doku mühendisliği yaklaşımının başlıca bileşenleri arasında doku spesifik hücreler, biyomateryaller ve doku oluşumunu destekleyici uygun çevre koşulları sayılabilir. Günümüzde deselülerize doku ve organlar, çok sayıda doku mühendisliği ve rejeneratif tıp uygulamalarında başarılı bir şekilde kullanılmaktadır. Uygulanan deselülerizasyon metotları, ilgili organ ve dokuların çeşidine göre değişmektedir. Dokudan en verimli şekilde hücrelerin uzaklaştırılması, dokunun orijini ile birlikte kullanılacak fiziksel, kimyasal ve biyolojik yollara bağlıdır. Bu noktada derleme kapsamında en yaygın kullanılan deselülerizasyon yöntemleri açıklanmış ve bu yöntemlerin biyolojik doku materyalini nasıl etkilediği nedenleri ile ifade edilmiştir.

References

  • Affonso da Costa FD, Dohmen PM, Lopes SV, Lacerda G, Pohl F, Vilani R, Affonso Da Costa MB, Vieira ED, Yoschi S, Konertz W, Affonso da Costa I. 2004. Comparison of cryopreserved homografts and decellularized porcine heterografts implanted in sheep. Artif Organs, 28:366–370.
  • Akbay E, Onur MA. 2016. Scaffold technologies: Using a natural platform for stem cell therapy. MEDJ, 31:205-212.
  • Akhyari P, Kamiya H, Gwanmesia P, Aubin H, Tschierschke R, Hoffmann S, Karck M, Lichtenberg A. 2010. In vivo functional performance and structural maturation of decellularised allogenic aortic valves in the subcoronary position. European Journal of Cardio-thoracic Surgery, 38:539-546.
  • Badylak S, Liang A, Record R, Tullius R, Hodde J. 1999. Endothelial cell adherence to small intestinal submucosa: an acellular bioscaffold. Biomaterials, 20:2257–2263.
  • Badylak SF, Tullius R, Kokini K, Shelbourne KD, Klootwyk T, Voytik SL, Kraine MR, Simmons C.1995. The use of xenogeneic small intestinal submucosa as a biomaterial for Achilles tendon repair in a dog model. J Biomed Mater Res, 29:977–985.
  • Badylak SF. 2004. Xenogeneic extracellular matrix as a scaffold for tissue reconstruction. Transplant Immunol, 12:367–377.
  • Borschel GH, Dennis RG, Kuzon Jr WM. 2004. Contractile skeletal muscle tissue-engineered on an acellular scaffold. Plast Reconstr Surg, 113:595–602.
  • Brown B, Lindberg K, Reing J, Stolz DB, Badylak SF. 2006. The basement membrane component of biologic scaffolds derived from extracellular matrix. Tissue Eng.12::519-526.
  • Cartmell JS, Dunn MG. 2000. Effect of chemical treatments on tendon cellularity and mechanical properties. J Biomed Mater Res, 49:134–140.
  • Chen RN, Ho HO, Tsai YT, Sheu MT. 2004. Process development of an acellular dermal matrix (ADM) for biomedical applications. Biomaterials, 25:2679–2686.
  • Cheng Y, Wang Y, Kang YZ, Hu PY, Gao Y, Pan MX. 2013. In vitro culture of tumour-derived hepatocytes in decellularised whole-liver biological scaffolds. Digestion, 87:189-195.
  • Conklin BS, Richter ER, Kreutziger KL, Zhong DS, Chen C. 2002. Development and evaluation of a novel decellularized vascular xenograft. Med Eng Phys, 24:173–183.
  • Constantinou CD, Jimenez SA. 1991. Structure of cDNAs encoding the triple-helical domain of murine alpha 2 (VI) collagen chain and comparison to human and chick homologues. Use of polymerase chain reaction and partially degenerate oligonucleotide for generation of novel cDNA clones. Matrix, 11:1–9.
  • Dahl SL, Koh J, Prabhakar V, Niklason LE. 2003. Decellularized native and engineered arterial scaffolds for transplantation. Cell Transplant, 12:659–666.
  • Du L, Wu X, Pang K, Yang Y. 2013. Histological evaluation and biomechanical characterisation of an acellular porcine cornea scaffold. Br J Ophthamol, 95:410-414.
  • Exposito JY, D’Alessio M, Solursh M, Ramirez F. 1992. Sea urchin collagen evolutionarily homologous to vertebrate pro-alpha 2(I) collagen. J Biol Chem, 267:15559–15562.
  • Falke G, Yoo JJ, Kwon TG, Moreland R, Atala A. 2003. Formation of corporal tissue architecture in vivo using human cavernosal muscle and endothelial cells seeded on collagen matrices. Tissue Eng, 9:871–879.
  • Faulk DM, Carruthers CA, Warner HJ, Kramer CR, Reing JE, Zhang L, D'Amore A, Badylak SF. 2014. The effect of detergents on the basement membrane complex of a biologic scaffold biomaterial. Acta Biomater, 10:1-21.
  • Fermor HL, Russell SL, Williams S, Fisher J, Ingham E. 2015. Development and characterisation of a desellularised bovine osteochondral biomaterial for cartilage repair. J Mater Sci: Mater Med, 26:186.
  • Freytes DO, Badylak SF, Webster TJ, Geddes LA, Rundell AE. 2004. Biaxial strength of multilaminated extracellular matrix scaffolds. Biomaterials, 25:2353–2361.
  • Gailit J, Ruoslahti E. 1988. Regulation of the fibronectin receptor affinity by divalent cations. J Biol Chem, 263:12927–12932.
  • Gamba PG, Conconi MT, Lo Piccolo R, Zara G, Spinazzi R, Parnigotto PP. 2002. Experimental abdominal wall defect repaired with acellular matrix. Pediatr Surg Int, 18:327–331.
  • Gilbert TW, Stolz DB, Biancaniello F, Simmons-Byrd A, Badylak SF. 2005. Production and characterization of ECM powder: implications for tissue engineering applications. Biomaterials, 26:1431–1435.
  • Goissis G, Suzigan S, Parreira DR, Maniglia JV, Braile DM, Raymundo S. 2000. Preparation and characterization of collagen–elastin matrices from blood vessels intended as small diameter vascular grafts. Artif Organs, 24:217–223.
  • Grauss RW, Hazekamp MG, Oppenhuizen F, van Munsteren CJ, Gittenberger-de Groot AC, DeRuiter MC. 2005. Histological evaluation of decellularised porcine aortic valves: matrix changes due to different decellularisation methods. Eur J Cardiothorac Surg, 27:566–571.
  • Gulati AK. 1988. Evaluation of acellular and cellular nerve grafts in repair of rat peripheral nerve. J Neurosurg, 68:117–123.
  • He M, Callanan A. 2013. Comparison of methods for whole-organ decellularization in tissue engineering of bioartificial organs. Tissue Engineering Part B, 19:1-15.
  • Hilbert SL, Yanagida R, Souza J, Wolfinbarger L, Jones AL, Krueger P, Stearns G, Bert A, Hopkins RA. 2004. Prototype anionic detergent technique used to decellularize allograft valve conduits evaluated in the right ventricular outflow tract in sheep. J Heart Valve Dis, 13:831–840.
  • Hodde J, Hiles M. 2002. Virus safety of a porcine-derived medical device: evaluation of a viral inactivation method. Biotechnol Bioeng, 79:211–216.
  • Hodde J, Record R, Tullius R, Badylak S. 2002a. Fibronectin peptides mediate HMEC adhesion to porcine-derived extracellular matrix. Biomaterials, 23:1841–1848.
  • Hodde JP, Badylak SF, Brightman AO, Voytik-Harbin SL. 1996. Glycosaminoglycan content of small intestinal submucosa: a bioscaf- fold for tissue replacement. Tissue Eng, 2:209–217.
  • Hodde JP, Record RD, Liang HA, Badylak SF. 2001. Vascular endothelial growth factor in porcine-derived extracellular matrix. Endothelium, 8:11–24.
  • Hodde JP, Record RD, Tullius RS, Badylak SF. 2002b. Retention of endothelial cell adherence to porcine-derived extracellular matrix after disinfection and sterilization. Tissue Eng, 8:225–234.
  • Hudson TW, Liu SY, Schmidt CE. 2004. Engineering an improved acellular nerve graft via optimized chemical processing. Tissue Eng, 10:1346–1358.
  • Jackson DW, Grood ES, Cohn BT, Arnoczky SP, Simon TM, Cummings JF. 1991. The effects of in situ freezing on the anterior cruciate ligament. An experimental study in goats. J Bone Joint Surg Am, 73:201–213.
  • Jackson DW, Windler GE, Simon TM. 1990. Intraarticular reaction associated with the use of freeze-dried, ethylene oxide-sterilized bone–patella tendon–bone allografts in the reconstruction of the anterior cruciate ligament. AmJ Sports Med, 18:1–10.
  • James GT. 1978. Inactivation of the protease inhibitor phenylmethylsulfonyl fluoride in buffers. Anal Biochem, 86:574-579.
  • Kasimir MT, Rieder E, Seebacher G, Silberhumer G, Wolner E, Weigel G, Simon P. 2003. Comparison of different decellularization procedures of porcine heart valves. Int J Artif Organs, 26:421–427.
  • Khorramirouz R, Sabetkish S, Akbarzadeh A, Muhammadnejad A, Heidari R, Kajbafzadeh AM. 2014. Effect of three decellularisation protocols on the mechanical behaviour and structural properties of sheep aortic valve conduits. Adv Med Sci, 59:299-307.
  • Kim BS, Yoo JJ, Atala A. 2004. Peripheral nerve regeneration using acellular nerve grafts. J Biomed Mater Res A, 68:201–209.
  • Kolker AR, Brown DJ, Redstone JS, Scarpinato VM, Wallack MK. 2005. Multilayer reconstruction of abdominal wall defects with acellular dermal allograft (AlloDerm) and component separation. Ann Plast Surg, 55:36–41.
  • Kropp BP, Eppley BL, Prevel CD, Rippy MK, Harruff RC, Badylak SF, Adams MC, Rink RC, Keating MA. 1995. Experimental assessment of small intestinal submucosa as a bladder wall substitute. Urology, 46:396–400.
  • Lee MS. 2004. GraftJacket augmentation of chronic Achilles tendon ruptures. Orthopedics, 27:151–153.
  • Lin P, Chan WC, Badylak SF, Bhatia SN. 2004. Assessing porcine liver- derived biomatrix for hepatic tissue engineering. Tissue Eng, 10:1046–1053.
  • McFetridge PS, Daniel JW, Bodamyali T, Horrocks M, Chaudhuri JB. 2004. Preparation of porcine carotid arteries for vascular tissue engineering applications. J Biomed Mater Res A, 70:224–234.
  • Methe K, Backdahl H, Johansson BR, Nayakawde N, Dellgren G, Sumitran-Holgersson S. 2014. An alternative approach to decellularize whole porcine heart. BioResearch, 3:327-338.
  • Moore R, Madara JL, MacLeod RJ. 1994. Enterocytes adhere preferen- tially to collagen IV in a differentially regulated divalent cation- dependent manner. Am J Physiol, 266: 1099–1107.
  • Muratov R, Britikov D, Sachklov A, Akatov V, Soloviev V, Fadeeva I, Bockeria L. 2010. New approach to reduce allograft tissue immunogenicity. Experimental data. Interactive CardioVascular and Thoracic Surgery, 10:408–412.
  • Pruss A, Kao M, Kiesewetter H, von Versen R, Pauli G. 1999. Virus safety of avital bone tissue transplants: evaluation of sterilization steps of spongiosa cuboids using a peracetic acid–methanol mixture. Biologicals, 27:195–201.
  • Rieder E, Kasimir MT, Silberhumer G, Seebacher G, Wolner E, Simon P, Weigel G. 2004. Decellularization protocols of porcine heart valves differ importantly in efficiency of cell removal and susceptibility of the matrix to recellularization with human vascular cells. J Thorac Cardiovasc Surg, 127:399–405.
  • Roberts TS, Drez Jr D, McCarthy W, Paine R. 1991. Anterior cruciate ligament reconstruction using freeze-dried, ethylene oxide-sterilized, bone–patellar tendon–bone allografts. Two year results in thirty-six patients. Am J Sports Med, 19:35–41.
  • Sano H, Orbay H, Terashi H, Hyakusoku H, Ogawa R. 2013. Acellular adipoe matrix as a natural scaffold for tissue engineering. JPRAS, 67:99-106.
  • Scarritt ME, Pashos NC, Bunnell BA. 2015. A review of cellularisation strategies for tissue engineering of whole organs. Frontiers in bioengineering and biotechnology, 3:43-60.
  • Schenke-Layland K, Vasilevski O, Opitz F, König K, Riemann I, Halbhuber KJ, Wahlers T, Stock UA. 2003. Impact of decellularization of xenogeneic tissue on extracellular matrix integrity for tissue engineering of heart valves. J Struct Biol, 143:201–208.
  • Seddon AM, Curnow P, Booth PJ. 2004. Membrane proteins, lipids and detergents: not just a soap opera. Biochim Biophys Acta, 1666:105–117.
  • Teebken OE, Bader A, Steinhoff G, Haverich A. 2000. Tissue engineering of vascular grafts: human cell seeding of decellularised porcine matrix. Eur J Vasc Endovasc Surg, 19:381–386.
  • Uchimura E, Sawa Y, Taketani S, Yamanaka Y, Hara M, Matsuda H, Miyake J. 2003. Novel method of preparing acellular cardiovascular grafts by decellularization with poly(ethylene glycol). J Biomed Mater Res A, 67:834–837.
  • Voet D, Voet JG, Pratt CW. 2002. Fundamentals of biochemistry. New York: Wiley.
  • Voytik-Harbin SL, Brightman AO, Kraine MR, Waisner B, Badylak SF. 1997. Identification of extractable growth factors from small intestinal submucosa. J Cell Biochem, 67:478–491.
  • Woods T, Gratzer PF. 2005. Effectiveness of three extraction techniques in the development of a decellularized bone–anterior cruciate liga- ment–bone graft. Biomaterials, 26:7339–7349.
  • Yang B, Zhang Y, Zhou L, Sun Z, Zheng J, Chen Y, Dai Y. 2010. Development of a porcine bladder acellular matrix with well-preserved extracellular bioactive factors for tissue engineering. Tissue Engineering: Part C, 16:1201-1211.
  • Yoo JJ, Meng J, Oberpenning F, Atala A. 1998. Bladder augmentation using allogenic bladder submucosa seeded with cells. Urology, 51:221–225.

Decellularization Methods of Organ and Tissue for Regenerative Medicine

Year 2016, Volume: 1 Issue: 2, 96 - 102, 29.12.2016

Abstract

The aim of tissue engineering and regenerative medicine is to rebuild tissues/organs for restoring injured parts of the body. Tissue specific cells, biomaterials and a convenient environment conditions are the most important parts of tissue engineering and regenerative medicine approaches. Nowadays, decellularized tissue and organs are being used successfully in a large number of tissue engineering and regenerative medicine implementations. Decellularization methods are differ in according to the type of the corresponding organs and tissues. The removal of cells from the tissue in the most efficient manner depends on physical, chemical and biological ways to use with the tissue origin. At this point within the scope of the review the most widely used decellularization methods are explained and how these methods affects the biological tissue material is described with reasons.

References

  • Affonso da Costa FD, Dohmen PM, Lopes SV, Lacerda G, Pohl F, Vilani R, Affonso Da Costa MB, Vieira ED, Yoschi S, Konertz W, Affonso da Costa I. 2004. Comparison of cryopreserved homografts and decellularized porcine heterografts implanted in sheep. Artif Organs, 28:366–370.
  • Akbay E, Onur MA. 2016. Scaffold technologies: Using a natural platform for stem cell therapy. MEDJ, 31:205-212.
  • Akhyari P, Kamiya H, Gwanmesia P, Aubin H, Tschierschke R, Hoffmann S, Karck M, Lichtenberg A. 2010. In vivo functional performance and structural maturation of decellularised allogenic aortic valves in the subcoronary position. European Journal of Cardio-thoracic Surgery, 38:539-546.
  • Badylak S, Liang A, Record R, Tullius R, Hodde J. 1999. Endothelial cell adherence to small intestinal submucosa: an acellular bioscaffold. Biomaterials, 20:2257–2263.
  • Badylak SF, Tullius R, Kokini K, Shelbourne KD, Klootwyk T, Voytik SL, Kraine MR, Simmons C.1995. The use of xenogeneic small intestinal submucosa as a biomaterial for Achilles tendon repair in a dog model. J Biomed Mater Res, 29:977–985.
  • Badylak SF. 2004. Xenogeneic extracellular matrix as a scaffold for tissue reconstruction. Transplant Immunol, 12:367–377.
  • Borschel GH, Dennis RG, Kuzon Jr WM. 2004. Contractile skeletal muscle tissue-engineered on an acellular scaffold. Plast Reconstr Surg, 113:595–602.
  • Brown B, Lindberg K, Reing J, Stolz DB, Badylak SF. 2006. The basement membrane component of biologic scaffolds derived from extracellular matrix. Tissue Eng.12::519-526.
  • Cartmell JS, Dunn MG. 2000. Effect of chemical treatments on tendon cellularity and mechanical properties. J Biomed Mater Res, 49:134–140.
  • Chen RN, Ho HO, Tsai YT, Sheu MT. 2004. Process development of an acellular dermal matrix (ADM) for biomedical applications. Biomaterials, 25:2679–2686.
  • Cheng Y, Wang Y, Kang YZ, Hu PY, Gao Y, Pan MX. 2013. In vitro culture of tumour-derived hepatocytes in decellularised whole-liver biological scaffolds. Digestion, 87:189-195.
  • Conklin BS, Richter ER, Kreutziger KL, Zhong DS, Chen C. 2002. Development and evaluation of a novel decellularized vascular xenograft. Med Eng Phys, 24:173–183.
  • Constantinou CD, Jimenez SA. 1991. Structure of cDNAs encoding the triple-helical domain of murine alpha 2 (VI) collagen chain and comparison to human and chick homologues. Use of polymerase chain reaction and partially degenerate oligonucleotide for generation of novel cDNA clones. Matrix, 11:1–9.
  • Dahl SL, Koh J, Prabhakar V, Niklason LE. 2003. Decellularized native and engineered arterial scaffolds for transplantation. Cell Transplant, 12:659–666.
  • Du L, Wu X, Pang K, Yang Y. 2013. Histological evaluation and biomechanical characterisation of an acellular porcine cornea scaffold. Br J Ophthamol, 95:410-414.
  • Exposito JY, D’Alessio M, Solursh M, Ramirez F. 1992. Sea urchin collagen evolutionarily homologous to vertebrate pro-alpha 2(I) collagen. J Biol Chem, 267:15559–15562.
  • Falke G, Yoo JJ, Kwon TG, Moreland R, Atala A. 2003. Formation of corporal tissue architecture in vivo using human cavernosal muscle and endothelial cells seeded on collagen matrices. Tissue Eng, 9:871–879.
  • Faulk DM, Carruthers CA, Warner HJ, Kramer CR, Reing JE, Zhang L, D'Amore A, Badylak SF. 2014. The effect of detergents on the basement membrane complex of a biologic scaffold biomaterial. Acta Biomater, 10:1-21.
  • Fermor HL, Russell SL, Williams S, Fisher J, Ingham E. 2015. Development and characterisation of a desellularised bovine osteochondral biomaterial for cartilage repair. J Mater Sci: Mater Med, 26:186.
  • Freytes DO, Badylak SF, Webster TJ, Geddes LA, Rundell AE. 2004. Biaxial strength of multilaminated extracellular matrix scaffolds. Biomaterials, 25:2353–2361.
  • Gailit J, Ruoslahti E. 1988. Regulation of the fibronectin receptor affinity by divalent cations. J Biol Chem, 263:12927–12932.
  • Gamba PG, Conconi MT, Lo Piccolo R, Zara G, Spinazzi R, Parnigotto PP. 2002. Experimental abdominal wall defect repaired with acellular matrix. Pediatr Surg Int, 18:327–331.
  • Gilbert TW, Stolz DB, Biancaniello F, Simmons-Byrd A, Badylak SF. 2005. Production and characterization of ECM powder: implications for tissue engineering applications. Biomaterials, 26:1431–1435.
  • Goissis G, Suzigan S, Parreira DR, Maniglia JV, Braile DM, Raymundo S. 2000. Preparation and characterization of collagen–elastin matrices from blood vessels intended as small diameter vascular grafts. Artif Organs, 24:217–223.
  • Grauss RW, Hazekamp MG, Oppenhuizen F, van Munsteren CJ, Gittenberger-de Groot AC, DeRuiter MC. 2005. Histological evaluation of decellularised porcine aortic valves: matrix changes due to different decellularisation methods. Eur J Cardiothorac Surg, 27:566–571.
  • Gulati AK. 1988. Evaluation of acellular and cellular nerve grafts in repair of rat peripheral nerve. J Neurosurg, 68:117–123.
  • He M, Callanan A. 2013. Comparison of methods for whole-organ decellularization in tissue engineering of bioartificial organs. Tissue Engineering Part B, 19:1-15.
  • Hilbert SL, Yanagida R, Souza J, Wolfinbarger L, Jones AL, Krueger P, Stearns G, Bert A, Hopkins RA. 2004. Prototype anionic detergent technique used to decellularize allograft valve conduits evaluated in the right ventricular outflow tract in sheep. J Heart Valve Dis, 13:831–840.
  • Hodde J, Hiles M. 2002. Virus safety of a porcine-derived medical device: evaluation of a viral inactivation method. Biotechnol Bioeng, 79:211–216.
  • Hodde J, Record R, Tullius R, Badylak S. 2002a. Fibronectin peptides mediate HMEC adhesion to porcine-derived extracellular matrix. Biomaterials, 23:1841–1848.
  • Hodde JP, Badylak SF, Brightman AO, Voytik-Harbin SL. 1996. Glycosaminoglycan content of small intestinal submucosa: a bioscaf- fold for tissue replacement. Tissue Eng, 2:209–217.
  • Hodde JP, Record RD, Liang HA, Badylak SF. 2001. Vascular endothelial growth factor in porcine-derived extracellular matrix. Endothelium, 8:11–24.
  • Hodde JP, Record RD, Tullius RS, Badylak SF. 2002b. Retention of endothelial cell adherence to porcine-derived extracellular matrix after disinfection and sterilization. Tissue Eng, 8:225–234.
  • Hudson TW, Liu SY, Schmidt CE. 2004. Engineering an improved acellular nerve graft via optimized chemical processing. Tissue Eng, 10:1346–1358.
  • Jackson DW, Grood ES, Cohn BT, Arnoczky SP, Simon TM, Cummings JF. 1991. The effects of in situ freezing on the anterior cruciate ligament. An experimental study in goats. J Bone Joint Surg Am, 73:201–213.
  • Jackson DW, Windler GE, Simon TM. 1990. Intraarticular reaction associated with the use of freeze-dried, ethylene oxide-sterilized bone–patella tendon–bone allografts in the reconstruction of the anterior cruciate ligament. AmJ Sports Med, 18:1–10.
  • James GT. 1978. Inactivation of the protease inhibitor phenylmethylsulfonyl fluoride in buffers. Anal Biochem, 86:574-579.
  • Kasimir MT, Rieder E, Seebacher G, Silberhumer G, Wolner E, Weigel G, Simon P. 2003. Comparison of different decellularization procedures of porcine heart valves. Int J Artif Organs, 26:421–427.
  • Khorramirouz R, Sabetkish S, Akbarzadeh A, Muhammadnejad A, Heidari R, Kajbafzadeh AM. 2014. Effect of three decellularisation protocols on the mechanical behaviour and structural properties of sheep aortic valve conduits. Adv Med Sci, 59:299-307.
  • Kim BS, Yoo JJ, Atala A. 2004. Peripheral nerve regeneration using acellular nerve grafts. J Biomed Mater Res A, 68:201–209.
  • Kolker AR, Brown DJ, Redstone JS, Scarpinato VM, Wallack MK. 2005. Multilayer reconstruction of abdominal wall defects with acellular dermal allograft (AlloDerm) and component separation. Ann Plast Surg, 55:36–41.
  • Kropp BP, Eppley BL, Prevel CD, Rippy MK, Harruff RC, Badylak SF, Adams MC, Rink RC, Keating MA. 1995. Experimental assessment of small intestinal submucosa as a bladder wall substitute. Urology, 46:396–400.
  • Lee MS. 2004. GraftJacket augmentation of chronic Achilles tendon ruptures. Orthopedics, 27:151–153.
  • Lin P, Chan WC, Badylak SF, Bhatia SN. 2004. Assessing porcine liver- derived biomatrix for hepatic tissue engineering. Tissue Eng, 10:1046–1053.
  • McFetridge PS, Daniel JW, Bodamyali T, Horrocks M, Chaudhuri JB. 2004. Preparation of porcine carotid arteries for vascular tissue engineering applications. J Biomed Mater Res A, 70:224–234.
  • Methe K, Backdahl H, Johansson BR, Nayakawde N, Dellgren G, Sumitran-Holgersson S. 2014. An alternative approach to decellularize whole porcine heart. BioResearch, 3:327-338.
  • Moore R, Madara JL, MacLeod RJ. 1994. Enterocytes adhere preferen- tially to collagen IV in a differentially regulated divalent cation- dependent manner. Am J Physiol, 266: 1099–1107.
  • Muratov R, Britikov D, Sachklov A, Akatov V, Soloviev V, Fadeeva I, Bockeria L. 2010. New approach to reduce allograft tissue immunogenicity. Experimental data. Interactive CardioVascular and Thoracic Surgery, 10:408–412.
  • Pruss A, Kao M, Kiesewetter H, von Versen R, Pauli G. 1999. Virus safety of avital bone tissue transplants: evaluation of sterilization steps of spongiosa cuboids using a peracetic acid–methanol mixture. Biologicals, 27:195–201.
  • Rieder E, Kasimir MT, Silberhumer G, Seebacher G, Wolner E, Simon P, Weigel G. 2004. Decellularization protocols of porcine heart valves differ importantly in efficiency of cell removal and susceptibility of the matrix to recellularization with human vascular cells. J Thorac Cardiovasc Surg, 127:399–405.
  • Roberts TS, Drez Jr D, McCarthy W, Paine R. 1991. Anterior cruciate ligament reconstruction using freeze-dried, ethylene oxide-sterilized, bone–patellar tendon–bone allografts. Two year results in thirty-six patients. Am J Sports Med, 19:35–41.
  • Sano H, Orbay H, Terashi H, Hyakusoku H, Ogawa R. 2013. Acellular adipoe matrix as a natural scaffold for tissue engineering. JPRAS, 67:99-106.
  • Scarritt ME, Pashos NC, Bunnell BA. 2015. A review of cellularisation strategies for tissue engineering of whole organs. Frontiers in bioengineering and biotechnology, 3:43-60.
  • Schenke-Layland K, Vasilevski O, Opitz F, König K, Riemann I, Halbhuber KJ, Wahlers T, Stock UA. 2003. Impact of decellularization of xenogeneic tissue on extracellular matrix integrity for tissue engineering of heart valves. J Struct Biol, 143:201–208.
  • Seddon AM, Curnow P, Booth PJ. 2004. Membrane proteins, lipids and detergents: not just a soap opera. Biochim Biophys Acta, 1666:105–117.
  • Teebken OE, Bader A, Steinhoff G, Haverich A. 2000. Tissue engineering of vascular grafts: human cell seeding of decellularised porcine matrix. Eur J Vasc Endovasc Surg, 19:381–386.
  • Uchimura E, Sawa Y, Taketani S, Yamanaka Y, Hara M, Matsuda H, Miyake J. 2003. Novel method of preparing acellular cardiovascular grafts by decellularization with poly(ethylene glycol). J Biomed Mater Res A, 67:834–837.
  • Voet D, Voet JG, Pratt CW. 2002. Fundamentals of biochemistry. New York: Wiley.
  • Voytik-Harbin SL, Brightman AO, Kraine MR, Waisner B, Badylak SF. 1997. Identification of extractable growth factors from small intestinal submucosa. J Cell Biochem, 67:478–491.
  • Woods T, Gratzer PF. 2005. Effectiveness of three extraction techniques in the development of a decellularized bone–anterior cruciate liga- ment–bone graft. Biomaterials, 26:7339–7349.
  • Yang B, Zhang Y, Zhou L, Sun Z, Zheng J, Chen Y, Dai Y. 2010. Development of a porcine bladder acellular matrix with well-preserved extracellular bioactive factors for tissue engineering. Tissue Engineering: Part C, 16:1201-1211.
  • Yoo JJ, Meng J, Oberpenning F, Atala A. 1998. Bladder augmentation using allogenic bladder submucosa seeded with cells. Urology, 51:221–225.
There are 62 citations in total.

Details

Journal Section 2016-Articles
Authors

Esin Akbay

Mehmet Ali Onur

Publication Date December 29, 2016
Acceptance Date December 16, 2016
Published in Issue Year 2016 Volume: 1 Issue: 2

Cite

APA Akbay, E., & Onur, M. A. (2016). Decellularization Methods of Organ and Tissue for Regenerative Medicine. Turkish Journal of Life Sciences, 1(2), 96-102.
AMA Akbay E, Onur MA. Decellularization Methods of Organ and Tissue for Regenerative Medicine. TJLS. December 2016;1(2):96-102.
Chicago Akbay, Esin, and Mehmet Ali Onur. “Decellularization Methods of Organ and Tissue for Regenerative Medicine”. Turkish Journal of Life Sciences 1, no. 2 (December 2016): 96-102.
EndNote Akbay E, Onur MA (December 1, 2016) Decellularization Methods of Organ and Tissue for Regenerative Medicine. Turkish Journal of Life Sciences 1 2 96–102.
IEEE E. Akbay and M. A. Onur, “Decellularization Methods of Organ and Tissue for Regenerative Medicine”, TJLS, vol. 1, no. 2, pp. 96–102, 2016.
ISNAD Akbay, Esin - Onur, Mehmet Ali. “Decellularization Methods of Organ and Tissue for Regenerative Medicine”. Turkish Journal of Life Sciences 1/2 (December 2016), 96-102.
JAMA Akbay E, Onur MA. Decellularization Methods of Organ and Tissue for Regenerative Medicine. TJLS. 2016;1:96–102.
MLA Akbay, Esin and Mehmet Ali Onur. “Decellularization Methods of Organ and Tissue for Regenerative Medicine”. Turkish Journal of Life Sciences, vol. 1, no. 2, 2016, pp. 96-102.
Vancouver Akbay E, Onur MA. Decellularization Methods of Organ and Tissue for Regenerative Medicine. TJLS. 2016;1(2):96-102.